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Cited by 252Extracellular vesicles in diseaseSpinal Cord Injury ResearchMesenchymal stem cell research

Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury

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Liu, Wen-zhao, Ma, Zhan-jun, Li, Jie-ru, Kang, Xue-wen·2021·Stem Cell Research & Therapy
DOI 10.1186/s13287-021-02153-8PMC PMC7860030
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Abstract

Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs below the injured segment. SCI not only results in physical and psychological harm to patients but can also cause a huge economic burden on their families and society. As there is no effective treatment method, the prevention, treatment, and rehabilitation of patients with SCI have become urgent problems to be solved. In recent years, mesenchymal stem cells (MSCs) have attracted more attention in the treatment of SCI. Although MSC therapy can reduce injured volume and promote axonal regeneration, its application is limited by tumorigenicity, a low survival rate, and immune rejection. Accumulating literature shows that exosomes have great potential in the treatment of SCI. In this review, we summarize the existing MSC-derived exosome studies on SCI and discuss the advantages and challenges of treating SCI based on exosomes derived from MSCs.

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Authors
Liu, W.-Z., Ma, Z.-J., Li, J.-R., & Kang, X.-W.
Affiliations
  • Lanzhou University Second Hospital (CN)
  • Lanzhou University (CN)
ORCID
Venue
Stem Cell Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2021-02-03
Volume
12
Issue
1
Pages
102-102
ISSN
1757-6512 (ISSN-L)
DOI
10.1186/s13287-021-02153-8
PMC
PMC7860030
OpenAlex
W3126534957
Cited by
252
References
173
Citations by year
2026: 36 · 2025: 58 · 2024: 58 · 2023: 58 · 2022: 28 · 2021: 14
FWCI
4.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cell Research & Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lanzhou University Institutional Repository (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Gansu Science and Technology Department (GZK-2019-46)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
spinal cord injury, mesenchymal stem cells, exosomes, cell-free therapy, axon regeneration, tumorigenicity, immune rejection
MeSH terms
Humans, Spinal Cord, Spinal Cord Injuries, Mesenchymal Stem Cell Transplantation, Exosomes, Mesenchymal Stem Cells

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