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Cited by 379

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone

Grunberg, Steven M., Weiss, Martin H., Spitz, Irving M., Ahmadi, Jamshid, Sadun, Alfredo, Russell, Christy A., Lucci, Lois, Stevenson, Lani L.·1991·Journal of Neurosurgery
DOI 10.3171/jns.1991.74.6.0861
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Abstract

✓ The possibility that meningioma growth may be related to female sex hormone levels is suggested by several lines of evidence. Meningiomas are twice as common in women as in men, have been observed to wax and wane with pregnancy, and are positively associated with breast cancer. A physiological explanation for these phenomena is provided by the finding of steroid hormone receptors in meningiomas. However, unlike breast cancer, meningiomas are much more commonly positive for progesterone receptors than for estrogen receptors. The authors initiated a study on long-term oral therapy of unresectable meningiomas with the antiprogesterone mifepristone (RU486). Fourteen patients received mifepristone in daily doses of 200 mg for periods ranging from 2 to 31+ months (≥ 6 months in 12 patients). Five patients have shown signs of objective response (reduced tumor measurement on computerized tomography scan or magnetic resonance image, or improved visual field examination). Three have also experienced subjective improvement (improved extraocular muscle function or relief from headache). The side effects of long-term mifepristone therapy have been mild. Fatigue was noted in 11 of the 14 patients. Other side effects included hot flashes in five patients, gynecomastia in three, partial alopecia in two, and cessation of menses in two. Long-term therapy with mifepristone is a new therapeutic option that may have efficacy in cases of unresectable benign meningioma.

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Metadata

Authors
Grunberg, S. M., Weiss, M. H., Spitz, I. M., Ahmadi, J., Sadun, A., Russell, C. A., Lucci, L., & Stevenson, L. L.
Venue
Journal of Neurosurgery
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Published
1991-06
Volume
74
Issue
6
Pages
861-866
ISSN
0022-3085 (ISSN-L)
DOI
10.3171/jns.1991.74.6.0861
OpenAlex
W1970539961
Cited by
379
References
12
FWCI
16.01
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone. https://app.cochat.ai/papers/10.3171/jns.1991.74.6.0861
The paper
Grunberg, S. M., Weiss, M. H., Spitz, I. M., Ahmadi, J., Sadun, A., Russell, C. A., Lucci, L., & Stevenson, L. L. (1991). Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone. Journal of Neurosurgery. https://doi.org/10.3171/jns.1991.74.6.0861

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.