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Cited by 317

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Successful Treatment of Cushing’s Syndrome with the Glucocorticoid Antagonist RU 486*

NIEMAN, LYNNETTE K., CHROUSOS, GEORGE P., KELLNER, CHARLES, SPITZ, IRVING M., NISULA, BRUCE C., CUTLER, GORDON B., MERRIAM, GEORGE R., BARDIN, C. WAYNE, LORIAUX, D. LYNN·1985·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-61-3-536
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Abstract

A patient with Cushing's syndrome due to ectopic ACTH secretion was treated successfully with the new glucocorticoid antagonist RU 486 [17 beta-hydroxy-11 beta-(4-dimethylamino phenyl) 17 alpha-(1-propynyl)estra-4,9-dien-3-one]. This compound is a 19-nor steroid with substitutions at positions C11 and C17 which antagonizes cortisol action competitively at the receptor level. Oral RU 486 was given in increasing doses of 5, 10, 15, and 20 mg/kg . day for a 9-week period. Treatment efficacy was monitored by assessment of clinical status and by measuring several glucocorticoid-sensitive variables, including fasting blood sugar, blood sugar 120 min after oral glucose administration, and plasma concentrations of TSH, corticosteroid-binding globulin, LH, testosterone-estradiol-binding globulin, and total and free testosterone. With therapy, the somatic features of Cushing's syndrome (buffalo hump, central obesity, and moon facies) ameliorated, mean arterial blood pressure normalized, suicidal depression resolved, and libido returned. All biochemical glucocorticoid-sensitive parameters normalized. No side-effects of drug toxicity were observed. We conclude that RU 486 may provide a safe, well tolerated, and effective medical treatment for hypercortisolism.

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Metadata

Authors
NIEMAN, L. K., CHROUSOS, G. P., KELLNER, C., SPITZ, I. M., NISULA, B. C., CUTLER, G. B., MERRIAM, G. R., BARDIN, C. W., & LORIAUX, D. L.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1985-09
Volume
61
Issue
3
Pages
536-540
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-61-3-536
OpenAlex
W2095590290
Cited by
317
References
18
FWCI
12.22
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Successful Treatment of Cushing’s Syndrome with the Glucocorticoid Antagonist RU 486*. https://app.cochat.ai/papers/10.1210/jcem-61-3-536
The paper
NIEMAN, L. K., CHROUSOS, G. P., KELLNER, C., SPITZ, I. M., NISULA, B. C., CUTLER, G. B., MERRIAM, G. R., BARDIN, C. W., & LORIAUX, D. L. (1985). Successful Treatment of Cushing’s Syndrome with the Glucocorticoid Antagonist RU 486*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-61-3-536

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.