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Edema from intracerebral hemorrhage: the role of thrombin
Abstract
✓ The mechanism by which intracerebral hemorrhage leads to the formation of brain edema is unknown. This study assesses the components of blood to determine if any are toxic to surrounding brain. Various solutions were infused stereotactically into the right basal ganglia of rats. The animals were sacrificed 24 hours later; brain edema and ion contents were measured. Whole blood caused an increase in brain water content and ion changes consistent with brain edema. Concentrated blood cells, serum from clotted blood, and plasma from unclotted blood all failed to provoke edema formation when infused directly into the brain. On the other hand, activation of the coagulation cascade by adding prothrombinase to plasma did produce brain edema. The edema response to whole blood could be prevented by adding a specific thrombin inhibitor, hirudin, to the injected blood. This study indicates that thrombin plays an important role in edema formation from an intracerebral blood clot.
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Cited by
Spontaneous intracerebral hemorrhage
Qureshi, A. I., Tuhrim, S., Broderick, J. P., Batjer, H. H., Hondo, H., & Hanley, D. F. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441907 · Cited by 1,719
(2006) · Cerebrovascular Diseases · doi:10.1159/000094831 · Cited by 411
Dabrowska, S., Andrzejewska, A., Lukomska, B., & Janowski, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1571-8 · Cited by 298
Brain Injury After Intracerebral Hemorrhage: The Role of Thrombin and Iron
Hua, Y., Keep, R. F., Hoff, J. T., & Xi, G. (2007) · Stroke · doi:10.1161/01.str.0000247868.97078.10 · Cited by 273
Self-citationTargeting secondary injury in intracerebral haemorrhage—perihaematomal oedema
Urday, S., Kimberly, W. T., Beslow, L. A., Vortmeyer, A. O., Selim, M. H., Rosand, J., Simard, J. M., & Sheth, K. N. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.264 · Cited by 274
Metadata
- Authors
- Lee, K. R., Colon, G. P., Betz, A. L., Keep, R. F., Kim, S., & Hoff, J. T.
- Venue
- Journal of Neurosurgery
- Published
- 1996-01
- Volume
- 84
- Issue
- 1
- Pages
- 91-96
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W2132343030
- Cited by
- 352
- References
- 0
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Edema from intracerebral hemorrhage: the role of thrombin. https://app.cochat.ai/papers/10.3171/jns.1996.84.1.0091
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- Lee, K. R., Colon, G. P., Betz, A. L., Keep, R. F., Kim, S., & Hoff, J. T. (1996). Edema from intracerebral hemorrhage: the role of thrombin. Journal of Neurosurgery. https://doi.org/10.3171/jns.1996.84.1.0091
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
