Brain Injury After Intracerebral Hemorrhage: The Role of Thrombin and Iron
Abstract
Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury.
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Iron excess aggravates the sequelae of stroke, and appropriate chelation or free radical trapping agents mitigate these effects.
“another prediction is that iron excess should also aggravate the sequelae of stroke, and that appropriate chelation or free radical trapping agents should mitigate these effects. These predictions are indeed borne out [138,905-914].”
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Research works printed but not linked: 1
- Xi G, Hua Y, Keep RF, Younger JG, Hoff JT. Systemic complement depletion diminishes perihematomal brain edema. Stroke. 2001;32: 162-167.
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- Authors
- Hua, Y., Keep, R. F., Hoff, J. T., & Xi, G.
- Affiliations
- University of Michigan (US)
- Venue
- Stroke
- Published
- 2007-02
- Volume
- 38
- Issue
- 2
- Pages
- 759-762
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2054135378
- Cited by
- 273
- References
- 40
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 19 · 2015: 17 · 2014: 16 · 2013: 20 · 2012: 19
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institute of Neurological Disorders and Stroke (R01NS047245, NS-39866, NS-47245, NS-17760, R01NS039866, R01NS017760)
- Topics
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- intracerebral hemorrhage, brain injury, thrombin, hemolysis, iron toxicity, hemorrhagic stroke, thrombin generation, therapeutic target
- MeSH terms
- Animals, Brain Injuries, Cerebral Hemorrhage, Humans, Iron, Thrombin
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