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Cited by 538

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up: Results of the third National Acute Spinal Cord Injury Randomized Controlled Trial

Bracken, Michael B., Shepard, Mary Jo, Holford, Theodore R., Leo-Summers, Linda, Aldrich, E. Francois, Fazl, Mahmood, Fehlings, Michael G., Herr, Daniel L., Hitchon, Patrick W., Marshall, Lawrence F., Nockels, Russ P., Pascale, Valentine, Perot, Phanor L., Piepmeier, Joseph, Sonntag, Volker K. H., Wagner, Franklin, Wilberger, Jack E., Winn, H. Richard, Young, Wise·1998·Journal of Neurosurgery
DOI 10.3171/jns.1998.89.5.0699
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Abstract

Object. A randomized double-blind clinical trial was conducted to compare neurological and functional recovery and morbidity and mortality rates 1 year after acute spinal cord injury in patients who had received a standard 24-hour methylprednisolone regimen (24MP) with those in whom an identical MP regimen had been delivered for 48 hours (48MP) or those who had received a 48-hour tirilazad mesylate (48TM) regimen. Methods. Patients for whom treatment was initiated within 3 hours of injury showed equal neurological and functional recovery in all three treatment groups. Patients for whom treatment was delayed more than 3 hours experienced diminished motor function recovery in the 24MP group, but those in the 48MP group showed greater 1-year motor recovery (recovery scores of 13.7 and 19, respectively, p = 0.053). A greater percentage of patients improving three or more neurological grades was also observed in the 48MP group (p = 0.073). In general, patients treated with 48TM recovered equally when compared with those who received 24MP treatments. A corresponding recovery in self care and sphincter control was seen but was not statistically significant. Mortality and morbidity rates at 1 year were similar in all groups. Conclusions. For patients in whom MP therapy is initiated within 3 hours of injury, 24-hour maintenance is appropriate. Patients starting therapy 3 to 8 hours after injury should be maintained on the regimen for 48 hours unless there are complicating medical factors.

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Metadata

Authors
Bracken, M. B., Shepard, M. J., Holford, T. R., Leo-Summers, L., Aldrich, E. F., Fazl, M., Fehlings, M. G., Herr, D. L., Hitchon, P. W., Marshall, L. F., Nockels, R. P., Pascale, V., Perot, P. L., Piepmeier, J., Sonntag, V. K. H., Wagner, F., Wilberger, J. E., Winn, H. R., & Young, W.
Venue
Journal of Neurosurgery
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Published
1998-11
Volume
89
Issue
5
Pages
699-706
ISSN
0022-3085 (ISSN-L)
DOI
10.3171/jns.1998.89.5.0699
OpenAlex
W2170677280
Cited by
538
References
26
FWCI
11.50
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up: Results of the third National Acute Spinal Cord Injury Randomized Controlled Trial. https://app.cochat.ai/papers/10.3171/jns.1998.89.5.0699
The paper
Bracken, M. B., Shepard, M. J., Holford, T. R., Leo-Summers, L., Aldrich, E. F., Fazl, M., Fehlings, M. G., Herr, D. L., Hitchon, P. W., Marshall, L. F., Nockels, R. P., Pascale, V., Perot, P. L., Piepmeier, J., Sonntag, V. K. H., Wagner, F., Wilberger, J. E., Winn, H. R., & Young, W. (1998). Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up: Results of the third National Acute Spinal Cord Injury Randomized Controlled Trial. Journal of Neurosurgery. https://doi.org/10.3171/jns.1998.89.5.0699

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.