The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Predictors of diabetes insipidus after transsphenoidal surgery: a review of 881 patients
Abstract
OBJECT: Diabetes insipidus (DI) is a common complication of transsphenoidal surgery. The purpose of this study was to elucidate patient- and surgery-specific risk factors for DI. METHODS: The perioperative records of 881 patients who had undergone transsphenoidal microsurgery at the authors' institution between January 1995 and June 2001 were reviewed. Among 857 patients without preoperative DI, the overall incidence of immediate postoperative DI was 18.3%, with 12.4% of patients requiring treatment with desmopressin at some point during their hospitalization. Persistent DI requiring long-term treatment with desmopressin was noted in 2% of all patients. An observable intraoperative cerebrospinal fluid (CSF) leak was strongly associated with an increased incidence of both transient (33.3%) and persistent (4.4%) DI. Craniopharyngioma and Rathke cleft cyst (RCC) were also associated with an increased incidence of transient and persistent DI, whereas repeated operation was not. Among patients with pituitary adenomas, those with Cushing's disease had an increased risk of transient (22.2%), but not persistent, DI. Patients with a microadenoma were more likely to suffer transient DI than those harboring a macroadenoma (21.6 compared with 14.3%) but were not more likely to experience persistent DI. CONCLUSIONS: Diabetes insipidus remains a common complication of transsphenoidal surgery; however, it is most frequently transient in nature. Patients with an intraoperative CSF leak, a microadenoma, a craniopharyngioma, or an RCC appear to have an increased risk of transient DI. Risk factors for persistent DI include an intraoperative CSF leak, a craniopharyngioma, or an RCC.
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“Disturbances in water homeostasis, most frequently due to cranial diabetes insipidus (DI), are commonly observed and appear to correlate with injury severity, with patients presenting lower GCS scores at higher risk [63,64].”
From Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions (2025) · cites this paper as [63]
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Cites
Ciric, I. S., Ragin, A. B., Baumgartner, C., & Pierce, D. (1997) · Neurosurgery · doi:10.1097/00006123-199702000-00001 · Cited by 1,023
Incidence and Management of Complications of Transsphenoidal Operation for Pituitary Adenomas
Black, P. M., Zervas, N. T., & CANDIA, G. L. (1987) · Neurosurgery · doi:10.1227/00006123-198706000-00017 · Cited by 358
Long-term Outcomes for Surgically Resected Craniopharyngiomas
Duff, J. M., Meyer, F. B., Ilstrup, D. M., Laws, E. R., Schleck, C. D., & Scheithauer, B. W. (2000) · Neurosurgery · doi:10.1097/00006123-200002000-00007 · Cited by 356
Transsphenoidal microsurgical removal of 250 pituitary adenomas
Wilson, C. B., & Dempsey, L. C. (1978) · Journal of neurosurgery · doi:10.3171/jns.1978.48.1.0013 · Cited by 352
Surgical treatment of craniopharyngiomas: endocrinological results
Honegger, J. B., Buchfelder, M., & Fahlbusch, R. (1999) · Journal of neurosurgery · doi:10.3171/jns.1999.90.2.0251 · Cited by 310
Hensen, J., Henig, A., Fahlbusch, R., Meyer, M. F., Boehnert, M. U., & Buchfelder, M. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00666.x · Cited by 266
Semple, P., & Laws, E. R. (1999) · Journal of neurosurgery · doi:10.3171/jns.1999.91.2.0175 · Cited by 218
El-Mahdy, W., & Powell, M. P. (1998) · Neurosurgery · doi:10.1097/00006123-199801000-00003 · Cited by 196
Surgery for Rathke cleft cysts: technical considerations and outcomes
Benveniste, R. J., King, W. A., Walsh, J. E., Lee, J. S., Naidich, T. P., & Post, K. D. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.4.0577 · Cited by 188
Pathophysiology of hyponatremia after transsphenoidal pituitary surgery
Olson, B. R., Gumowski, J., Rubino, D., & Oldfield, E. H. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.87.4.0499 · Cited by 180
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- 10.1210/jc.80.1.85 · DOI
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Lacroix, A., Feelders, R. A., Stratakis, C. A., & Nieman, L. K. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61375-1 · Cited by 1,777
Zada, G., Lin, N., Ojerholm, E., Ramkissoon, S. H., & Laws, E. R. (2010) · Neurosurgical FOCUS · doi:10.3171/2010.2.focus09318 · Cited by 271
Katznelson, L. J., Atkinson, J. L. D., Cook, D. M., Ezzat, S., Hamrahian, A. H., & Miller, K. K. (2011) · Endocrine Practice · doi:10.4158/ep.17.s4.1 · Cited by 260
Current State and Future Perspectives in the Diagnosis of Diabetes Insipidus: A Clinical Review
Fenske, W. K., & Allolio, B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1981 · Cited by 221
“Twenty to 30% of pituitary surgeries lead to transient CDI, and 2–10% lead to permanent disease (8, 9), with a risk of postoperative neuronal damage depending on the height of hypothalamic-hypophyseal tract destruction; sections above the median eminence cause a permanent form of disease, whereas sections below the me…”
BackgroundPITUITARY HORMONAL LOSS AND RECOVERY AFTER TRANSSPHENOIDAL ADENOMA REMOVAL
Fatemi, N., Dusick, J. R., Mattozo, C. A., McArthur, D. L., Cohan, P., Boscardin, W. J., Wang, C., Swerdloff, R. S., & Kelly, D. F. (2008) · Neurosurgery · doi:10.1227/01.neu.0000325725.77132.90 · Cited by 220
“4 to 15% but is typically 3% or less (1, 8, 10, 12, 18, 19, 24, 25, 37).”
BackgroundInfluential
Metadata
- Authors
- Nemergut, E. C., Zuo, Z., Jane, J. A., & Laws, E. R.
- Affiliations
- University of Virginia Health System (US)
- Venue
- Journal of neurosurgery
- Published
- 2005-09
- Volume
- 103
- Issue
- 3
- Pages
- 448-454
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W2141699689
- Cited by
- 313
- References
- 34
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 21 · 2023: 21 · 2022: 26 · 2021: 22 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 20 · 2016: 10 · 2015: 24 · 2014: 8 · 2013: 14 · 2012: 14
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Virginia
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
- Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
- Keywords
- diabetes insipidus, transsphenoidal surgery, postoperative complications, risk factors, desmopressin, cerebrospinal fluid leak, craniopharyngioma, Rathke's cleft cyst, pituitary adenoma, Cushing's disease, pituitary microadenoma, macroadenoma
- MeSH terms
- Adenoma, Craniopharyngioma, Diabetes Insipidus, Humans, Pituitary Neoplasms, Prognosis, Retrospective Studies, Sphenoid Sinus, Subdural Effusion, Incidence, Central Nervous System Cysts
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