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Safety and efficacy of a novel polyethylene glycol hydrogel sealant for watertight dural repair
Abstract
Object: The authors prospectively evaluated the safety and efficacy of a novel polyethylene glycol (PEG) hydrogel sealant in patients undergoing elective cranial surgery with documented cerebrospinal fluid (CSF) leakage after sutured dural repair. Methods: The PEG hydrogel sealant was used at 11 different study sites in 111 patients with documented intraoperative CSF leakage after neurosurgical dural repair for a variety of conditions. Intraoperative CSF leakage was either spontaneous or induced by a Valsalva maneuver. Patients were monitored for 3 months postoperatively with physical examinations, clinical laboratory analyses, and diagnostic imaging. The PEG hydrogel sealant was 100% effective in stopping CSF leakage in all patients. There were no sealant-related adverse events and all clinical outcomes were consistent with expectations for seriously ill patients undergoing prolonged neurosurgical procedures. Conclusions: The PEG hydrogel sealant provides a safe and effective watertight closure when used as an adjunct to sutured dural repair during cranial surgery.
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Citations
Cited by
Nam, S., & Mooney, D. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00798 · Cited by 764
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Bouten, P. J. M., Zonjee, M., Bender, J., Yauw, S. T. K., van Goor, H., van Hest, J. C. M., & Hoogenboom, R. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.02.001 · Cited by 448
Ren, H., Zhang, Z., Cheng, X., Zou, Z., Chen, X., & He, C. (2023) · Science Advances · doi:10.1126/sciadv.adh4327 · Cited by 431
An injectable and instant self-healing medical adhesive for wound sealing
Sun, F., Bu, Y., Chen, Y., Yang, F., Yu, J., & Wu, D. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c01022 · Cited by 117
Metadata
- Authors
- Cosgrove, G. R., Delashaw, J. B., Grotenhuis, J. A., Tew, J. M., van Loveren, H., Spetzler, R. F., Payner, T., Rosseau, G., Shaffrey, M. E., Hopkins, L. N., Byrne, R., & Norbash, A.
- Venue
- Journal of Neurosurgery
- Published
- 2007-01
- Volume
- 106
- Issue
- 1
- Pages
- 52-58
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W2170942934
- Cited by
- 168
- References
- 0
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Safety and efficacy of a novel polyethylene glycol hydrogel sealant for watertight dural repair. https://app.cochat.ai/papers/10.3171/jns.2007.106.1.52
- The paper
- Cosgrove, G. R., Delashaw, J. B., Grotenhuis, J. A., Tew, J. M., van Loveren, H., Spetzler, R. F., Payner, T., Rosseau, G., Shaffrey, M. E., Hopkins, L. N., Byrne, R., & Norbash, A. (2007). Safety and efficacy of a novel polyethylene glycol hydrogel sealant for watertight dural repair. Journal of Neurosurgery. https://doi.org/10.3171/jns.2007.106.1.52
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
