Polymeric tissue adhesives
Abstract
Polymeric tissue adhesives provide versatile materials for wound management and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries. Compared to the traditional methods of wound closure (i.e., suturing and stapling), they are relatively easy to use, enable rapid application, and introduce minimal tissue damage. Furthermore, they can act as hemostats to control bleeding and provide a tissue-healing environment at the wound site. Despite their numerous current applications, tissue adhesives still face several limitations and unresolved challenges (e.g., weak adhesion strength and poor mechanical properties) that limit their use, leaving ample room for future improvements. Successful development of next-generation adhesives will likely require a holistic understanding of the chemical and physical properties of the tissue-adhesive interface, fundamental mechanisms of tissue adhesion, and requirements for specific clinical applications. In this review, we discuss a set of rational guidelines for design of adhesives, recent progress in the field along with examples of commercially available adhesives and those under development, tissue-specific considerations, and finally potential functions for future adhesives. Advances in tissue adhesives will open new avenues for wound care and potentially provide potent therapeutics for various medical applications.
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Under oxidation, covalent bonding can form with the amino or sulfhydryl groups on the surface of biological tissues through Schiff base reaction or Michael addition.
“Under this circumstance, covalent bonding can form with the amino or sulfhydryl groups on the surface of biological tissues through Schiff base reaction or Michael addition [13].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [13]
In oxidation conditions, the catechol group can transfer to a quinone structure; the formed quinone is capable of reacting with the -NH2 group and -SH group, thus improving the crosslinking density.
“In addition, in oxidation conditions, the catechol group can transfer to a quinone structure. The formed quinone is capable of reacting with the -NH2 group and -SH group, thus improving the crosslinking density [13].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [13]
In an alkaline environment, catechol groups are prone to oxidation to form catechol-catechol dimers.
“In an alkaline environment, catechol groups are prone to oxidation to form catechol–catechol dimers [13].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [13]
In clinical practice, suturing is still the dominant way to close open wounds.
“In clinical practice, suturing is still the dominant way to close open wounds [13,92].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [13]
Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382 · see citing works
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146 · see citing works
Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures
Yuk, H., Zhang, T., Parada, G. A., Liu, X., & Zhao, X. (2016) · Nature Communications · doi:10.1038/ncomms12028 · Cited by 1,035 · see citing works
Gan, D., Xing, W., Jiang, L., Fang, J., Zhao, C., Ren, F., Fang, L., Wang, K., & Lu, X. (2019) · Nature Communications · doi:10.1038/s41467-019-09351-2 · Cited by 1,029 · see citing works
Biofabrication strategies for 3D in vitro models and regenerative medicine
Moroni, L., Burdick, J. A., Highley, C., Lee, S. J., Morimoto, Y., Takeuchi, S., & Yoo, J. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0006-y · Cited by 753 · see citing works
Glial responses to implanted electrodes in the brain
Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642 · see citing works
Viscoelastic hydrogels for 3D cell culture
Chaudhuri, O. (2017) · Biomaterials Science · doi:10.1039/c7bm00261k · Cited by 353 · see citing works
Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite
Sharma, B., Fermanian, S., Gibson, M., Unterman, S., Herzka, D. A., Cascio, B., Coburn, J., Hui, A. Y., Marcus, N., Gold, G. E., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004838 · Cited by 342 · see citing works
Polyglycolic Acid-Induced Inflammation: Role of Hydrolysis and Resulting Complement Activation
Ceonzo, K., Gaynor, A., Shaffer, L., Kojima, K., Vacanti, C. A., & Stahl, G. L. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.301 · Cited by 209 · see citing works
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Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“…to a quinone structure [12]. surface of biological tissues through Schi ff base reaction Under this circumstance, covalent bonding can form with the amino or sulfhydryl groups on the surface of biological tissues through Schiff base reaction or Michael addition [13]. or Michael addition [13].”
BackgroundInfluentialErdi, M., Rozyyev, S., Balabhadrapatruni, M., Saruwatari, M. S., Daristotle, J. L., Ayyub, O. B., Sandler, A. D., & Kofinas, P. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10335 · Cited by 25 · see citing works
- Authors
- Nam, S., & Mooney, D.
- Affiliations
- Harvard University (US)
- Corresponding author
- Mooney, David
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-01-28
- Volume
- 121
- Issue
- 18
- Pages
- 11336-11384
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3125852379
- Cited by
- 764
- References
- 9
- Citations by year
- 2026: 135 · 2025: 199 · 2024: 159 · 2023: 149 · 2022: 94 · 2021: 28
- FWCI
- 25.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novartis
- National Institute of Biomedical Imaging and Bioengineering (2R01 DE013349)
- Topics
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- tissue adhesives, polymer adhesives, wound closure, hemostasis, adhesive design, wound healing, adhesion strength, mechanical properties
- MeSH terms
- Polymers, Tissue Adhesives, Wound Healing
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