The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Relationship between Tumor Enhancement, Edema,IDH1 Mutational Status,MGMT Promoter Methylation, and Survival in Glioblastoma
Open accessAbstract
BACKGROUND AND PURPOSE: Both IDH1 mutation and MGMT promoter methylation are associated with longer survival. We investigated the ability of imaging correlates to serve as noninvasive biomarkers for these molecularly defined GBM subtypes. MATERIALS AND METHODS: MR imaging from 202 patients with GBM was retrospectively assessed for nonenhancing tumor and edema among other imaging features. IDH1 mutational and MGMT promoter methylation status were determined by DNA sequencing and methylation-specific PCR, respectively. Overall survival was determined by using a multivariate Cox model and the Kaplan-Meier method with a log rank test. A logistic regression model followed by ROC analysis was used to classify the IDH1 mutation and methylation status by using imaging features. RESULTS: MGMT promoter methylation and IDH1 mutation were associated with longer median survival. Edema levels stratified survival for methylated but not unmethylated tumors. Median survival for methylated tumors with little/no edema was 2476 days (95% CI, 795), compared with 586 days (95% CI, 507-654) for unmethylated tumors or tumors with edema. All IDH1 mutant tumors were nCET positive, and most (11/14, 79%) were located in the frontal lobe. Imaging features including larger tumor size and nCET could be used to determine IDH1 mutational status with 97.5% accuracy, but poorly predicted MGMT promoter methylation. CONCLUSIONS: Imaging features are potentially predictive of IDH1 mutational status but were poorly correlated with MGMT promoter methylation. Edema stratifies survival in MGMT promoter methylated but not in unmethylated tumors; patients with methylated tumors with little or no edema have particularly long survival.
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An Integrated Genomic Analysis of Human Glioblastoma Multiforme
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Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
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Self-citationGlioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
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Analysis of the IDH1 codon 132 mutation in brain tumors
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FDA Drug Approval Summary: Bevacizumab (Avastin®) as Treatment of Recurrent Glioblastoma Multiforme
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Self-citationRole of imaging in the era of precision medicine
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Jansen, R. W., van Amstel, P., Martens, R. M., Kooi, I. E., Wesseling, P., de Langen, A. J., Menke-Van der Houven van Oordt, C. W., Jansen, B. H. E., Moll, A. C., Dorsman, J. C., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24893 · Cited by 63
Metadata
- Authors
- Carrillo, J. A., Lai, A., Nghiemphu, P. L., Kim, H. J., Phillips, H. S., Kharbanda, S., Moftakhar, P., Lalaezari, S., Yong, W., Ellingson, B. M., Cloughesy, T. F., & Pope, W. B.
- Venue
- American Journal of Neuroradiology
- Published
- 2012-02-09
- Volume
- 33
- Issue
- 7
- Pages
- 1349-1355
- ISSN
- 0195-6108 (ISSN-L)
- 1936-959X
- OpenAlex
- W2165274879
- Cited by
- 299
- References
- 43
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Carrillo, J. A., Lai, A., Nghiemphu, P. L., Kim, H. J., Phillips, H. S., Kharbanda, S., Moftakhar, P., Lalaezari, S., Yong, W., Ellingson, B. M., Cloughesy, T. F., & Pope, W. B. (2012). Relationship between Tumor Enhancement, Edema,IDH1 Mutational Status,MGMT Promoter Methylation, and Survival in Glioblastoma. American Journal of Neuroradiology. https://doi.org/10.3174/ajnr.a2950
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