The DOI matches its Crossref record.
Susceptibility Rhythm to E. coli Endotoxin and Bioassay.
Abstract
Light-synchronized periodicity analysis reveals a susceptibility rhythm in C mice to E. coli endotoxin. Susceptibility varies predictably and significantly along the 24-hour time scale. A dose of endotoxin which is compatible with survival of most animals when given during middle of daily dark period is highly lethal when it is given 8-12 hours earlier or later. LD50 also was determined for 2 samples from identical batch of endotoxin tested 12 h apart on separate groups of comparable C mice kept under conditions standardized for periodicity analysis: Differences in potency significant at 1% were seen at 2 dose levels common to both assays, the computed “potency ratio” being 3.22.
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“Conversely, there are hints that owing to an overshooting proinflammatory cytokine response, the immediate defense of antigen is impaired during sleep, particularly during SWS (508,627,693,779).”
From About Sleep's Role in Memory (2013) · cites this paper as [508]
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
“Conversely, there are hints that owing to an overshooting proinflammatory cytokine response, the immediate defense of antigen is impaired during sleep, particularly during SWS (508, 627, 693, 779).”
BackgroundCircadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135
A circadian clock in macrophages controls inflammatory immune responses
Keller, M., Mazuch, J., Abraham, U., Eom, G. D., Herzog, E. D., Volk, H.-D., Kramer, A., & Maier, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906361106 · Cited by 843
“Why should the response to bacterial endotoxin in macrophages be regulated in a time of day-dependent manner? The dramatic diurnal variations in survival rate observed in an endotoxic shock mouse model first described by Halberg and colleagues (21, 22, 34) suggest a biological significance of the timing of immune func…”
BackgroundMcEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Gibbs, J. E., Blaikley, J., Beesley, S., Matthews, L. C., Simpson, K. D., Boyce, S., Farrow, S. N., Else, K. J., Singh, D., Ray, D. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106750109 · Cited by 692
“In mice, significant temporal dependence of LPS-induced endotoxic shock has been reported (3), and circadian disruption mimicking jet lag can greatly magnify LPS response (4).”
Background
Metadata
- Authors
- Halberg, F., Johnson, E. A., Brown, B. W., & Bittner, J. J.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1960-01-01
- Volume
- 103
- Issue
- 1
- Pages
- 142-144
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2321428190
- Cited by
- 280
- References
- 0
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 21 · 2023: 16 · 2022: 12 · 2021: 13 · 2020: 19 · 2019: 14 · 2018: 9 · 2017: 14 · 2016: 12 · 2015: 8 · 2014: 11 · 2013: 11 · 2012: 11
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- endotoxin, Escherichia coli, circadian rhythm, periodicity analysis, light synchronization, mice, LD50, dose-response relationship, time of administration
- MeSH terms
- Biological Assay, Endotoxins, Escherichia coli, Humans
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