The DOI matches its Crossref record.
Studies of the Diabetogenic Action of Streptozotocin.
Abstract
Streptozotocin is a highly effective cytotoxic agent for pancreatic B-cells. After intravenous administration of 65 mg streptozotocin per kg, damage to B-cells is apparent as early as one hour after intravenous administration of the drug. Frank necrosis associated with phagocytosis is best seen after 7 hours, when pancreatic insulin release and hypoglycemia are also noted. By 24 hours, pancreatic insulin content is reduced to 5% of normal or less. While the B-cytotoxic effects of streptozotocin resemble those of alloxan, their specificity is very much greater, as demonstrated by the wide margin between diabetogenic dose and general toxicity.
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Citations
Cited by
Diabetogenic action of streptozotocin: relationship of dose to metabolic response
Junod, A., Lambert, A. E., Stauffacher, W., & Renold, A. E. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106180 · Cited by 930
Self-citationO-GlcNAcase Uses Substrate-assisted Catalysis
Macauley, M. S., Whitworth, G. E., Debowski, A. W., Chin, D., & Vocadlo, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413819200 · Cited by 377
Guz, Y., Nasir, I., & Teitelman, G. (2001) · Endocrinology · doi:10.1210/endo.142.11.8501 · Cited by 254
Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart
Jones, S. P., Girod, W. G., Granger, D. N., Palazzo, A. J., & Lefer, D. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h763 · Cited by 80
Conjugation of hyaluronan to proteins
Mero, A., Pasqualin, M., Campisi, M., Renier, D., & Pasut, G. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.11.090 · Cited by 69
Metadata
- Authors
- Junod, A., Lambert, A. E., Orci, L., Pictet, R., Gonet, A. E., & Renold, A. E.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1967-10-01
- Volume
- 126
- Issue
- 1
- Pages
- 201-205
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2092169341
- Cited by
- 491
- References
- 0
- FWCI
- 27.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Junod, A., Lambert, A. E., Orci, L., Pictet, R., Gonet, A. E., & Renold, A. E. (1967). Studies of the Diabetogenic Action of Streptozotocin. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-126-32401
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
