The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Regeneration of Pancreatic β Cells from Intra-Islet Precursor Cells in an Experimental Model of Diabetes
Open accessAbstract
We previously reported that new beta cells differentiated in pancreatic islets of mice in which diabetes was produced by injection of a high dose of the beta cell toxin streptozotocin (SZ), which produces hyperglycemia due to rapid and massive beta cell death. After SZ-mediated elimination of existing beta cells, a population of insulin containing cells reappeared in islets. However, the number of new beta cells was small, and the animals remained severely hyperglycemic. In the present study, we tested whether restoration of normoglycemia by exogenous administered insulin would enhance beta cell differentiation and maturation. We found that beta cell regeneration improved in SZ-treated mice animals that rapidly attained normoglycemia following insulin administration because the number of beta cells per islet reached near 40% of control values during the first week after restoration of normoglycemia. Two presumptive precursor cell types appeared in regenerating islets. One expressed the glucose transporter-2 (Glut-2), and the other cell type coexpressed insulin and somatostatin. These cells probably generated the monospecific cells containing insulin that repopulated the islets. We conclude that beta cell neogenesis occurred in adult islets and that the outcome of this process was regulated by the insulin-mediated normalization of circulating blood glucose levels.
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Cites
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Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
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Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
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Cited by
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Ianus, A., Holz, G. G., Theise, N. D., & Hussain, M. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16502 · Cited by 772
Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W., Wright, C. V. E., White, M. F., Arden, K. C., & Accili, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16857 · Cited by 580
Regulation of pancreatic beta-cell mass
Bouwens, L., & Rooman, I. (2005) · Physiological Reviews · doi:10.1152/physrev.00025.2004 · Cited by 411
All β Cells Contribute Equally to Islet Growth and Maintenance
Brennand, K., Huangfu, D., & Melton, D. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050163 · Cited by 210
Metadata
- Authors
- Guz, Y., Nasir, I., & Teitelman, G.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2001-11-01
- Volume
- 142
- Issue
- 11
- Pages
- 4956-4968
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2050551968
- Cited by
- 254
- References
- 38
- FWCI
- 17.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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