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Scrapie in Mice: Ultrastructural Observations in the Cerebral Cortex
Abstract
Cerebral cortex obtained from scrapie infected mice was examined in the electron microscope. Three structures of unknown origin and significance were observed: (a) enlarged cell processes containing particles and rods, (b) enlarged cell processes occupied by varicose tubules filled with moderately dense material and (c) oval bodies formed by parallel bands and fibrils which were usually but not always, in a ring-like arrangement. These structures were generally associated in one way or another with synaptic terminals, but on rare occasions, they were found in unidentified cell processes. The possible significance of the presence of these structures in scrapie infected mouse brain is discussed.
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Cited by
Scrapie prions aggregate to form amyloid-like birefringent rods
Prusiner, S. B., McKinley, M. P., Bowman, K. A., Bolton, D. C., Bendheim, P. E., Groth, D. F., & Glenner, G. G. (1983) · Cell · doi:10.1016/0092-8674(83)90168-x · Cited by 1,043
Insights into prion strains and neurotoxicity
Aguzzi, A., Heikenwalder, M., & Polymenidou, M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2204 · Cited by 329
Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease
Kretzschmar, H. A., Ironside, J. W., DeArmond, S. J., & Tateishi, J. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550090125018 · Cited by 288
Prion strain discrimination using luminescent conjugated polymers
Sigurdson, C. J., Nilsson, K. P. R., Hornemann, S., Manco, G., Polymenidou, M., Schwarz, P., Leclerc, M., Hammarström, P., Wüthrich, K., & Aguzzi, A. (2007) · Nature Methods · doi:10.1038/nmeth1131 · Cited by 273
Numbers of Hirano bodies in the hippocampus of normal and demented people with Alzheimer's disease
Gibson, P. H., & Tomlinson, B. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90193-9 · Cited by 118
Metadata
- Authors
- David-ferreira, J. F., David-ferreira, K. L., Gibbs, C. J., & Morris, J. A.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1968-01-01
- Volume
- 127
- Issue
- 1
- Pages
- 313-320
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2325854321
- Cited by
- 185
- References
- 0
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Scrapie in Mice: Ultrastructural Observations in the Cerebral Cortex. https://app.cochat.ai/papers/10.3181/00379727-127-32680
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- David-ferreira, J. F., David-ferreira, K. L., Gibbs, C. J., & Morris, J. A. (1968). Scrapie in Mice: Ultrastructural Observations in the Cerebral Cortex. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-127-32680
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
