Phosphorylation, Oxidation, and Ubiquinone Content in Diabetic Mitochondria
Abstract
Respiratory and phosphorylat-ing activities were determined in liver mitochondria from mild and severely diabetic rats. Diabetes was caused by 95% pancreatectomy performed 6-18 months before the investigation of mitochondrial function. Diabetic mitochondria showed depressed respiratory rates with β-hydroxybutyrate, L-malate-L-glutamate, and succinate as substrates while the P:O ratios did not depart from the normal control values, with all the employed substrates. Ubiquinone levels were significantly increased in mitochondria from severely diabetic rats while cytochrome c and mitochondrial protein remained unchanged.
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In liver and muscle mitochondria isolated from rodents or cats with insulin-deficient diabetes induced by pancreatectomy, alloxan, or streptozotocin, respiration on complex I or complex II substrates is decreased.
“Early studies revealed decreased respiration on complex I or complex II substrates in liver and muscle mitochondria isolated from rodents or cats made diabetic by pancreatectomy, alloxan, or streptozotocin (38, 119, 127, 322).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [38]
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“[55] have also shown that CoQ levels significantly increased in liver mitochondria isolated from rats made diabetic by pancreatectomy.”
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THE PARTICIPATION OF COENZYME Q IN FREE PRODUCTION AND ANTIOXIDATION RADICAL
Beyer, R. E. (1990)
- Authors
- Boveris, A. A., Ramos, M. C. D. P., Stoppani, A. O. M., & Foglia, V. G.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1969-10-01
- Volume
- 132
- Issue
- 1
- Pages
- 171-174
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2316884798
- Cited by
- 18
- References
- 0
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- diabetes mellitus, liver mitochondria, mitochondrial respiration, mitochondrial phosphorylation, coenzyme Q10, P/O ratio, beta-hydroxybutyrate, succinic acid, pancreatic resection, oxidative phosphorylation, cytochrome c
- MeSH terms
- Animals, Blood Glucose, Cytochromes, Diabetes Mellitus, Male, Mitochondria, Liver, Oxidation-Reduction, Pancreatectomy, Ubiquinone, Rats
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