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A Method for the Large Scale Production of Potent Interferon Preparations
Abstract
A method has been described for the large scale production of potent mouse interferon preparations based on the cultivation and induction of cells in suspension culture. By the selective use of metabolic inhibitors and the choice of optimal culture conditions, large quantities of interferon titering 4 × 105 mouse reference units/ml (specific activity 106 reference units/mg of protein), were consistently obtained. It was found that the inducing virus could be recovered at the end of the adsorption period and reutilized at least seven times without loss of its interferon inducing capacity. Although this method has been described for the production of mouse interferon using C243-3 cells it is applicable to the production of human or other interferons from cells which multiply in suspension culture.
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Cited by
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Sistigu, A., Yamazaki, T., Vacchelli, E., Chaba, K., Enot, D. P., Adam, J., Vitale, I., Goubar, A., Baracco, E. E., Remédios, C., et al. (2014) · Nature Medicine · doi:10.1038/nm.3708 · Cited by 1,042
Staeheli, P., Haller, O., Boll, W., Lindenmann, J., & Weissmann, C. (1986) · Cell · doi:10.1016/0092-8674(86)90493-9 · Cited by 488
Mattei, F., Schiavoni, G., Belardelli, F., & Tough, D. F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1179 · Cited by 459
Schiavoni, G., Sistigu, A., Valentini, M., Mattei, F., Sestili, P., Spadaro, F., Sanchez, M., Lorenzi, S., D'Urso, M. T., Belardelli, F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2788 · Cited by 362
Metadata
- Authors
- Tovey, M. G., Begon-Lours, J., & Gresser, I.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1974-07-01
- Volume
- 146
- Issue
- 3
- Pages
- 809-815
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2327730411
- Cited by
- 182
- References
- 0
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Method for the Large Scale Production of Potent Interferon Preparations. https://app.cochat.ai/papers/10.3181/00379727-146-38196
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- Tovey, M. G., Begon-Lours, J., & Gresser, I. (1974). A Method for the Large Scale Production of Potent Interferon Preparations. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-146-38196
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
