The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation
Open accessAbstract
Cytokines that are induced by infection may contribute to the initiation of immune responses through their ability to stimulate dendritic cells (DCs). In this paper, we have addressed the role of IL-15 in DC activation, investigating its expression by DCs in response to three different signals of infection and examining its ability to stimulate DCs. We report that the expression of both IL-15 and the IL-15 receptor α-chain are increased in splenic DCs from mice inoculated with dsRNA (poly(I:C)), LPS, or IFN-αβ, and in purified murine splenic DCs treated with IFN-αβ in vitro. Furthermore, IL-15 itself was able to activate DCs, as in vivo or in vitro exposure of splenic DCs to IL-15 resulted in an up-regulation of costimulatory molecules, markedly increased production of IFN-γ by DC and an enhanced ability of DCs to stimulate Ag-specific CD8+ T cell proliferation. The magnitude of all of the IL-15-induced changes in DCs was reduced in mice deficient for the IFN-αβ receptor, suggesting a role for IFN-αβ in the stimulation of DCs by IL-15. These results identify IL-15 as a stimulatory cytokine for DCs with the potential for autocrine activity and link its effects to expression of IFN-αβ.
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Cites
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Self-citation
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Metadata
- Authors
- Mattei, F., Schiavoni, G., Belardelli, F., & Tough, D. F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-08-01
- Volume
- 167
- Issue
- 3
- Pages
- 1179-1187
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2160915452
- Cited by
- 459
- References
- 68
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation. https://app.cochat.ai/papers/10.4049/jimmunol.167.3.1179
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- Mattei, F., Schiavoni, G., Belardelli, F., & Tough, D. F. (2001). IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.3.1179
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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