Sexual Differences in the Expression of Copper Deficiency in Rats
Abstract
The present investigation was undertaken to establish whether the severity of copper deficiency in rats fed diets containing fructose is affected by the presence and type of endogenous sex hormones. Intact and castrated male rats and intact and ovariectomized females were fed from weaning a copper-deficient diet (0.6 ppm) containing 62% fructose for 8 weeks. Regardless of castration, male rats were anemic, exhibited heart hypertrophy, and died of the deficiency. However, castration ameliorated the anemia and delayed the mortality. In contrast, none of the females died of the deficiency. It is suggested that in addition to the sex of the animal, levels of testosterone in the male may also play a role in the severity of copper deficiency.
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Studies of dietary copper deficiency in rats indicate that females exhibit less severe symptoms of weight loss, anemia and lethality.
“Studies of dietary copper deficiency in rats indicate that females exhibit less severe symptoms of weight loss, anemia and lethality 16, 17, 18.”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [18]
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Taylor, L. C., Gilmore, W., & Matsushima, G. K. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00230.x · Cited by 84 · see citing works
- Authors
- Fields, M., Lewis, C. G., Beal, T., Scholfield, D., Patterson, K., Smith, J. C., & Reiser, S.
- Affiliations
- Georgetown University (US)
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1987-11-01
- Volume
- 186
- Issue
- 2
- Pages
- 183-187
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2035284792
- Cited by
- 39
- References
- 0
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- copper deficiency, sex differences, testosterone, castration, ovariectomy, fructose, anemia, cardiac hypertrophy, mortality, trace element deficiency, rats
- MeSH terms
- Animals, Body Weight, Ceruloplasmin, Copper, Diet, Estradiol, Female, Male, Orchiectomy, Organ Size, Ovariectomy, Sex Characteristics, Gonadal Steroid Hormones, Superoxide Dismutase, Testosterone, Rats
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