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Corticotropin-Releasing Factor (CRF) and Endocrine Responses to Stress: CRF Receptors, Binding Protein, and Related Peptides
Abstract
Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide, which is recognized as a critical mediator of complimentary, stress-related endocrine, autonomic, and behavioral responses in mammalian species. CRF belongs to a family of structurally related peptides including frogskin sauvagine and fish urotensin I. The effects of CRF and related peptides are mediated by two distinct receptors, which differ in their anatomical distribution, as well as in their pharmacological characteristics. In addition, CRF is bound with high affinity by a CRF binding protein (CRF-BP), which is a putative inhibitor of CRF action. CRF is probably not the sole endogenous ligand for CRF receptors or the CRF-BP, since a second mammalian member of the CRF family, urocortin, has recently been identified. This article describes recent findings with respect to CRF, its receptors, binding protein, and CRF-related peptides, which provide further insights into the role and mechanisms of CRF action in stress responses.
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“CRF is a 41 amino-acid residue peptide that plays a key role in orchestrating the endocrine, behavioral, and GI responses to stress (for review, see [327][328][329]).”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [328]
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“Corticotrophinreleasing factor (CRF) and urocortin stimulate pituitary POMC gene expression in mammals (Vaughan et al., 1995; Turnbull and Rivier, 1997; Asaba et al., 1998; Hsu and Hsueh, 2001) and POMC-derived secretion in the placenta (Petraglia et al., 1999) and pituitary (Vaughan et al., 1995;…”
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“UCN has been shown to produce physiological/pharmacological effects that, in general, are similar to those produced by CRF [8–15].”
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“The CRF system has been implicated in not only regulating endocrine, autonomic, visceral and immune responses to stress, but behavioral responses as well (Turnbull and Rivier, 1997; Ogilvie et al., 1998; Koob and Heinrichs, 1999).”
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Metadata
- Authors
- Turnbull, A. V., & Rivier, C.
- Affiliations
- Salk Institute for Biological Studies (US)
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1997-05-01
- Volume
- 215
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2334462456
- Cited by
- 256
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 2 · 2014: 9 · 2013: 10 · 2012: 13
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH051774, NIMH51774)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDDK-26741)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD013527, NICHD-13527)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- corticotropin-releasing factor, CRF receptors, CRF-binding protein, urocortin, stress response, endocrine stress response, sauvagine, urotensin I, neuropeptides, autonomic stress response, behavioral stress response
- MeSH terms
- Adrenocorticotropic Hormone, Amino Acid Sequence, Animals, Carrier Proteins, Corticotropin-Releasing Hormone, Humans, Luteinizing Hormone, Molecular Sequence Data, Neuropeptides, Stress, Physiological, Receptors, Corticotropin-Releasing Hormone
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