The DOI matches its Crossref record.
Enzyme Inhibition in Relation to Chemotherapy.
Abstract
1. The effect of enzyme concentration on the inhibition produced by certain inhibitors of the succinic dehydrogenase system has been experimentally determined. The inhibitors studied were malonate, itaconate, oxalacetate, quinone and cupric ion.
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In the citing paper
“it also appears to play a major role in embryo implantation in the womb, a process thought to require immunosuppression70–72.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [70]
In the citing paper
“our data suggest that itaconate acts as a competitive SDH inhibitor in immune cells”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]
In the citing paper
“Although itaconate has been shown previously to inhibit SDH ex vivo (26 -28)”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]
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Lampropoulou, V., Sergushichev, A., Bambousková, M., Nair, S., Vincent, E. E., Loginicheva, E., Cervantes‐Barragán, L., Ma, X., Huang, S. C., Griss, T., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.004 · Cited by 1,583
“Indeed, 67 years ago, an inhibitory effect of itaconate on Sdh was postulated based on similar effects of malonate and itaco- nate on mitochondria function (Ackermann and Potter, 1949).”
InfluentialItaconate: the poster child of metabolic reprogramming in macrophage function
O'Neill, L. A. J., & Artyomov, M. N. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0128-5 · Cited by 643
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
Santi, D. V., McHenry, C. S., & Sommer, H. (1974) · Biochemistry · doi:10.1021/bi00700a012 · Cited by 624
Williams, N. C., & O'Neill, L. A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00141 · Cited by 599
Cordes, T., Wallace, M., Michelucci, A., Divakaruni, A. S., Sapcariu, S. C., Sousa, C., Koseki, H., Cabrales, P., Murphy, A. N., Hiller, K., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.685792 · Cited by 526
“Indeed, in vitro enzyme activity assays using isolated SDH and respiratory studies have indicated that itaconate can reduce the activity of SDH (27, 28, 37).”
Metadata
- Authors
- Ackermann, W. W., & Potter, V. R.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1949-10-01
- Volume
- 72
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2315543398
- Cited by
- 262
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2013: 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- enzyme inhibition, succinate dehydrogenase, succinate dehydrogenase inhibitors, malonate, itaconate, oxaloacetate, quinones, copper(II) ions, enzyme concentration, chemotherapy
- MeSH terms
- Biochemical Phenomena, Drug Therapy, Enzymes, Humans
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