The DOI matches its Crossref record.
Enzyme Inhibition in Relation to Chemotherapy.
Abstract
1. The effect of enzyme concentration on the inhibition produced by certain inhibitors of the succinic dehydrogenase system has been experimentally determined. The inhibitors studied were malonate, itaconate, oxalacetate, quinone and cupric ion.
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“it also appears to play a major role in embryo implantation in the womb, a process thought to require immunosuppression70–72.”
From Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) · cites this paper as [70]
In the citing paper
“our data suggest that itaconate acts as a competitive SDH inhibitor in immune cells”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]
In the citing paper
“Although itaconate has been shown previously to inhibit SDH ex vivo (26 -28)”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [27]
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Lampropoulou, V., Sergushichev, A., Bambousková, M., Nair, S., Vincent, E. E., Loginicheva, E., Cervantes‐Barragán, L., Ma, X., Huang, S. C., Griss, T., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.004 · Cited by 1,583
“Indeed, 67 years ago, an inhibitory effect of itaconate on Sdh was postulated based on similar effects of malonate and itaco- nate on mitochondria function (Ackermann and Potter, 1949).”
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“Indeed, in vitro enzyme activity assays using isolated SDH and respiratory studies have indicated that itaconate can reduce the activity of SDH (27, 28, 37).”
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Metadata
- Authors
- Ackermann, W. W., & Potter, V. R.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1949-10-01
- Volume
- 72
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2315543398
- Cited by
- 262
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2013: 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- enzyme inhibition, succinate dehydrogenase, succinate dehydrogenase inhibitors, malonate, itaconate, oxaloacetate, quinones, copper(II) ions, enzyme concentration, chemotherapy
- MeSH terms
- Biochemical Phenomena, Drug Therapy, Enzymes, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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