The DOI matches its Crossref record.
Toxicity of Penicillin for the Syrian Hamster
Abstract
A single injection of crystalline penicillin G potassium administered subcutaneously or intraperitoneally is toxic for hamsters in proportion to amount administered. Toxicity is of the delayed type, the vast majority of deaths occurring on 3rd, 4th and 5th days following injection. This parallels the reported experience with guinea pigs and is in contrast to Swiss mice who easily tolerate very large doses of this antibiotic. In the light of these findings, reevaluation of experimental data concerned with Syrian hamsters either treated with or injected with material sterilized with penicillin would seem to be indicated.
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“The main causes of failure are lack of effectiveness and safety problems that were not predicted by animal tests.40”
From The Flaws and Human Harms of Animal Experimentation (2015) · cites this paper as [40]
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The Flaws and Human Harms of Animal Experimentation
AKHTAR, A. (2015) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s0963180115000079 · Cited by 527
Clindamycin-Associated Colitis Due to a Toxin-Producing Species of Clostridium in Hamsters
Bartlett, J. G., Onderdonk, A. B., Cisneros, R. L., & Kasper, D. L. (1977) · The Journal of Infectious Diseases · doi:10.1093/infdis/136.5.701 · Cited by 471
Rifkin, G. D., Silva, J., & Fekety, R. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90355-4 · Cited by 60
Patulin mycotoxicosis in Swiss ICR mice
McKinley, E. R., & Carlton, W. W. (1980) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(80)90072-3 · Cited by 57
The association of viral activation with penicillin toxicity in guinea pigs and hamsters.
Green, R. H. (1974) · PubMed Central · Cited by 51
Metadata
- Authors
- Schneierson, S. S., & Perlman, E.
- Affiliations
- Mount Sinai Hospital (US)
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1956-02-01
- Volume
- 91
- Issue
- 2
- Pages
- 229-230
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2028224961
- Cited by
- 22
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 1 · 2015: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- penicillin G potassium, drug toxicity, golden hamster, delayed toxicity, subcutaneous injection, intraperitoneal injection
- MeSH terms
- Animals, Cricetinae, Mesocricetus, Penicillins
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