Increase in Induced Pulmonary Tumors in Mice Associated with Exposure To High Concentration of Oxygen
Abstract
Strain A mice injected at 2 months of age with dibenz [a, h] anthracene and immediately thereafter exposed for 48 hours to approximately 100% oxygen had when killed and examined 4 months later a significantly greater average number of pulmonary tumors than did the controls injected with dibenz [a, h] anthracene and kept in air.
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In 1956, Heston and Pratt showed that elevated oxygen uptake increased lung tumor initiation in mice.
“In 1956, Heston and Pratt began to study the role of oxygen in lung tumors, and the results showed that elevated oxygen uptake increased lung tumor initiation in mice.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [286]
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Role of oxygen radicals in tumor promotion
Kensler, T. W., & Trush, M. A. (1984) · Environmental Mutagenesis · doi:10.1002/em.2860060412 · Cited by 172 · see citing works
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Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
Hyperbaric oxygen in radiation therapy
Glassburn, J. R., Brady, L. W., & Plenk, H. P. (1977) · Cancer · doi:10.1002/1097-0142(197702)39:2+ · Cited by 32 · see citing works
Gottlieb, S. F. (1966) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)60413-8 · Cited by 19 · see citing works
Structure-Activity Relationships
Arcos, J. C., & Argus, M. F. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-059302-6.50006-5 · Cited by 12 · see citing works
Effect of Cobaltous Chloride on the Minimal Carcinogenic Dose50 of Methylcholanthrene in Albino Mice
Kasirsky, G., Gautieri, R. F., & Mann, D. E. (1965) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600540345 · Cited by 8 · see citing works
Structure–Activity Relationships
WOO, Y.-T., Lai, D. Y., ARCOS, J. C., & ARGUS, M. F. (1988) · Elsevier eBooks · doi:10.1016/b978-0-12-059353-8.50007-x · Cited by 5 · see citing works
Orzechowski, R. F., Gautieri, R. F., & Mann, D. E. (1965) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600540115 · Cited by 5 · see citing works
The influence of prolonged oxygen change on the formation of spontaneous and induced mouse cancer.
DiPaolo, J. A., & MOORE, G. E. (1959) · PubMed · Cited by 3 · see citing works
Effect of prenatal hypoxia on spontaneous leukemia in mice.
Altschul, R., MacFadyen, D. J., & Whitehead, W. F. (1957) · PubMed · Cited by 2 · see citing works
- Authors
- Heston, W. E., & Pratt, A. W.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1956-06-01
- Volume
- 92
- Issue
- 2
- Pages
- 451-454
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2326379099
- Cited by
- 10
- References
- 0
- Citations by year
- 2023: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- hyperoxia, high oxygen concentration, lung cancer, dibenzo[a,h]anthracene, chemical carcinogenesis, tumor promotion, mice
- MeSH terms
- Animals, Lung Neoplasms, Neoplasms, Experimental, Oxygen, Mice
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