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Post-traumatic stress disorder vs traumatic brain injury
Open accessAbstract
Post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) often coexist because brain injuries are often sustained in traumatic experiences. This review outlines the significant overlap between PTSD and TBI by commencing with a critical outline of the overlapping symptoms and problems of differential diagnosis. The impact of TBI on PTSD is then described, with increasing evidence suggesting that mild TBI can increase risk for PTSD. Several explanations are offered for this enhanced risk. Recent evidence suggests that impairment secondary to mild TBI is largely attributable to stress reactions after TBI, which challenges the long-held belief that postconcussive symptoms are a function of neurological insult This recent evidence is pointing to new directions for treatment of postconcussive symptoms that acknowledge that treating stress factors following TBI may be the optimal means to manage the effects of many TBIs.
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“As TBI increases the risk of PTSD109 and Alzheimer’s disease110, these data may help us understand the factors that make higher brain circuits so vulnerable to insult.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [109]
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Metadata
- Authors
- Bryant, R.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Bryant, Richard
- ORCID
- Bryant, Richard
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2011-09-30
- Volume
- 13
- Issue
- 3
- Pages
- 251-262
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC3182010
- OpenAlex
- W4296930895
- Cited by
- 268
- References
- 106
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 21 · 2023: 16 · 2022: 14 · 2021: 24 · 2020: 22 · 2019: 16 · 2018: 33 · 2017: 13 · 2016: 20 · 2015: 24 · 2014: 20 · 2013: 12 · 2012: 4
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- post-traumatic stress disorder, traumatic brain injury, mild traumatic brain injury, post-concussion symptoms, differential diagnosis
- MeSH terms
- Brain Injuries, Cognition Disorders, Humans, Stress Disorders, Post-Traumatic
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