Hantavirus Infection in Humans and Rodents, Northwestern Argentina
Open accessAbstract
We initiated a study to elucidate the ecology and epidemiology of hantavirus infections in northern Argentina. The northwestern hantavirus pulmonary syndrome (HPS)-endemic area of Argentina comprises Salta and Jujuy Provinces. Between 1997 and 2000, 30 HPS cases were diagnosed in Jujuy Province (population 512,329). Most patients had a mild clinical course, and the death rate (13.3%) was low. We performed a serologic and epidemiologic survey in residents of the area, in conjunction with a serologic study in rodents. The prevalence of hantavirus antibodies in the general human population was 6.5%, one of the highest reported in the literature. No evidence of interhuman transmission was found, and the high prevalence of hantavirus antibody seemed to be associated with the high infestation of rodents detected in domestic and peridomestic habitats.
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Evidence from comparative studies does not support human-to-human transmission of hantavirus infection, with the exception of 1 prospective cohort study in Chile with serious risk of bias and no unexposed comparison group.
“Evidence from comparative studies (the strongest level of evidence available) does not support human-to-human transmission of hantavirus infection [12, 15, 27, 34, 36, 38], with the exception of 1 prospective cohort study in Chile with serious RoB and no unexposed comparison group [29].”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [12]
Other studies in Argentina and Chile did not find evidence of human-to-human transmission of hantavirus.
“other studies in Argentina [12, 13] and Chile [14, 15] did not find evidence of it.”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [12]
The cross-sectional study of residents of Yuto, Jujuy Province, Argentina, did not find any difference in prevalence of IgG to hantavirus in those with previous contact with a known HPS patient compared to those without (6.1% vs 6.6%; χ2 = 0.03, P = .86).
“The second, a cross-sectional study of residents of Yuto, Jujuy Province in northern Argentina (specific hantavirus not clear), did not find any difference in prevalence of IgG to hantavirus in those with previous contact with a known HPS patient compared to those without previous contact (6.1% vs 6.6%; χ 2 = 0.03, P = .86) [12].”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [12]
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Cites
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Self-citationLaguna Negra Virus Associated with HPS in Western Paraguay and Bolivia
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Research works printed but not linked: 2
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Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review
Toledo, J., Haby, M. M., Reveiz, L., Sosa Leon, L., Angerami, R., & Aldighieri, S. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab461 · Cited by 78 · see citing works
“Pini 2003 [12] Argentina 2000 ? Cross-sectional seroprevalence and epidemiologic survey of residents of the area, in conjunction with a serologic study in rodents.”
BackgroundInfluential
- Authors
- Pini, N., Levis, S., Calderón, G., Ramirez, J., Bravo, D., Lozano, E., Ripoll, C., St. Jeor, S., Ksiazek, T. G., Barquez, R. M., & Enria, D.
- Affiliations
- Instituto Nacional de Enfermedades Virales Humanas “Dr. Julio I. Maiztegui,” Pergamino, Argentina;
- Hospital Italiano de Montevideo (UY)
- Hospital Oscar Orias, Libertador General San Martín, Jujuy, Argentina;
- Dirección de Epidemiología, Jujuy, Argentina;
- University of Nevada, Reno, Nevada, USA;
- Centers for Disease Control and Prevention (US)
- Universidad Nacional de Tucumán, Tucumán, Argentina;Consejo Nacional de Investigaciones Científicas y Técnicas, Tucumán, Argentina
- ORCID
- Ksiazek, Thomas G.
- Venue
- Emerging Infectious Diseases
- Published
- 2003-09
- Volume
- 9
- Issue
- 9
- Pages
- 1070-1076
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC3016789
- OpenAlex
- W2159979721
- Cited by
- 56
- References
- 12
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 7
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Greater South Information System
- Funders
- National Institute of Allergy and Infectious Diseases (1R01 AI 45059, R01AI045059)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- hantavirus, hantavirus pulmonary syndrome, rodent-borne zoonoses, rodent infestation, peridomestic habitats, interhuman transmission, hantavirus ecology, Jujuy, Salta
- MeSH terms
- Adolescent, Adult, Aged, Animals, Antibodies, Viral, Argentina, Child, Child, Preschool, Cross-Sectional Studies, Disease Outbreaks, Female, Orthohantavirus, Humans, Male, Middle Aged, Rodentia, Prevalence, Hantavirus Infections
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