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Cited by 201Viral Infections and VectorsVirology and Viral DiseasesViral Infections and Outbreaks Research

Hantavirus Pulmonary Syndrome: The First 100 US Cases

Khan, A. S., Khabbaz, R. F., Armstrong, L. R., Holman, R. C., Bauer, S. P., Graber, J., Strine, T., Miller, G. +9 more·1996·Journal of Infectious Diseases
DOI 10.1093/infdis/173.6.1297
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Abstract

In the spring of 1993, hantavirus pulmonary syndrome (HPS) "emerged" in the southwestern United States, where a multiagency investigation led to the rapid description of this new clinical entity and its etiology. Analysis of the first 100 US cases identified showed that the disease was distributed in 21 states, had gone unrecognized since at least 1959, and had a distinct spring-early summer seasonality. Of the infected persons, 54% were male; 63% were Caucasian, 35% were Native American, and 2% were African American. The average age of case-patients was 34.9 years, and 8 were children or adolescents aged < or = 16 years. The overall case-fatality rate was 52%. There was a 91% concordance among serologic, immunohistochemical, and molecular results. HPS in the United States is caused by at least three newly described pathogenic hantaviruses, each of which has a distinct rodent host, and cases of HPS have been recently recognized in Canada and South America. National surveillance of this sporadic disease remains essential for further defining the epidemiology and clinical spectrum.

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Authors
Khan, A. S., Khabbaz, R. F., Armstrong, L. R., Holman, R. C., Bauer, S. P., Graber, J., Strine, T., Miller, G., Reef, S., Tappero, J., Rollin, P. E., Nichol, S. T., Zaki, S. R., Bryan, R. T., Chapman, L. E., Peters, C. J., & Ksiazek, T. G.
Affiliations
Centers for Disease Control and Prevention (US)
Corresponding author
Khan, A. S.
ORCID
Venue
Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1996-06-01
Volume
173
Issue
6
Pages
1297-1303
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/173.6.1297
OpenAlex
W2008261581
Cited by
201
References
0
Citations by year
2026: 8 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 3 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 8
FWCI
10.77
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords
hantavirus pulmonary syndrome, hantavirus, hantavirus pulmonary hemorrhagic syndrome, case series, seasonal variation, case fatality rate, serological diagnosis, immunohistochemistry, molecular diagnosis, rodent hosts, disease surveillance, southwestern United States
MeSH terms
Adolescent, Adult, Aged, Animals, Child, Ethnicity, Female, Humans, Male, Middle Aged, Peromyscus, Seasons, United States, Sigmodontinae, Age Distribution, Sex Distribution, Hantavirus Pulmonary Syndrome

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