The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence
Open accessAbstract
Before childhood vaccination was introduced in the 1940s, pertussis was a major cause of infant death worldwide. Widespread vaccination of children succeeded in reducing illness and death. In the 1990s, a resurgence of pertussis was observed in a number of countries with highly vaccinated populations, and pertussis has become the most prevalent vaccine-preventable disease in industrialized countries. We present evidence that in the Netherlands the dramatic increase in pertussis is temporally associated with the emergence of Bordetella pertussis strains carrying a novel allele for the pertussis toxin promoter, which confers increased pertussis toxin (Ptx) production. Epidemiologic data suggest that these strains are more virulent in humans. We discuss changes in the ecology of B. pertussis that may have driven this adaptation. Our results underline the importance of Ptx in transmission, suggest that vaccination may select for increased virulence, and indicate ways to control pertussis more effectively.
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Cites
Parkhill, J., Sebaihia, M., Preston, A., Murphy, L. D., Thomson, N., Harris, D. E., Holden, M. T. G., Churcher, C. M., Bentley, S. D., Mungall, K. L., et al. (2003) · Nature Genetics · doi:10.1038/ng1227 · Cited by 1,037
Imperfect vaccines and the evolution of pathogen virulence
Gandon, S., Mackinnon, M. J., Nee, S., & Read, A. F. (2001) · Nature · doi:10.1038/414751a · Cited by 630
Diavatopoulos, D. A., Cummings, C. A., Schouls, L. M., Brinig, M. M., Relman, D. A., & Mooi, F. R. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010045 · Cited by 296
Self-citationCherry, J. D. (2005) · Pediatrics · doi:10.1542/peds.2004-2648 · Cited by 237
How best to estimate the global burden of pertussis?
Crowcroft, N., Stein, C., Duclos, P., & Birmingham, M. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00669-8 · Cited by 224
Immunity Promotes Virulence Evolution in a Malaria Model
Mackinnon, M. J., & Read, A. F. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020230 · Cited by 189
de Melker, H. E., Versteegh, F. G. A., Schellekens, J. F. P., Teunis, P. F. M., & Kretzschmar, M. (2006) · Journal of Infection · doi:10.1016/j.jinf.2005.10.020 · Cited by 171
Self-citationMultilocus Sequence Typing of Bordetella pertussis Based on Surface Protein Genes
van Loo, I. H. M., Heuvelman, K. J., King, A. J., & Mooi, F. R. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.6.1994-2001.2002 · Cited by 153
Self-citationKirimanjeswara, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24609 · Cited by 152
The Control of Pertussis — 2007 and Beyond
Halperin, S. A. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068288 · Cited by 125
Cited by
Pertussis: Microbiology, Disease, Treatment, and Prevention
Kilgore, P. E., Salim, A. M., Zervos, M. J., & Schmitt, H.-J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00083-15 · Cited by 434
Metadata
- Authors
- Mooi, F. R., van Loo, I. H. M., van Gent, M., He, Q., Bart, M. J., Heuvelman, K. J., de Greeff, S. C., Diavatopoulos, D., Teunis, P., Nagelkerke, N., & Mertsola, J.
- Venue
- Emerging Infectious Diseases
- Published
- 2009-08
- Volume
- 15
- Issue
- 8
- Pages
- 1206-1213
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- OpenAlex
- W2097334445
- Cited by
- 351
- References
- 14
- FWCI
- 21.21
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Mooi, F. R., van Loo, I. H. M., van Gent, M., He, Q., Bart, M. J., Heuvelman, K. J., de Greeff, S. C., Diavatopoulos, D., Teunis, P., Nagelkerke, N., & Mertsola, J. (2009). Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence. Emerging Infectious Diseases. https://doi.org/10.3201/eid1508.081511
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
