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Cited by 1,037Bacterial Infections and VaccinesMicrobial infections and disease researchGenomics and Phylogenetic Studies

Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica

Parkhill, Julian, Sebaihia, Mohammed, Preston, Andrew, Murphy, Lee D, Thomson, Nicholas, Harris, David E, Holden, Matthew T G, Churcher, Carol M +45 more·2003·Nature Genetics
DOI 10.1038/ng1227
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Abstract

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. B. parapertussis can also cause whooping cough, and B. bronchiseptica causes chronic respiratory infections in a wide range of animals. We sequenced the genomes of B. bronchiseptica RB50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. pertussis Tohama I (4,086,186 bp; 3,816 genes). Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. During the evolution of these two host-restricted species there was large-scale gene loss and inactivation; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.

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Authors
Parkhill, J., Sebaihia, M., Preston, A., Murphy, L. D., Thomson, N., Harris, D. E., Holden, M. T. G., Churcher, C. M., Bentley, S. D., Mungall, K. L., Cerdeño-Tárraga, A. M., Temple, L., James, K., Harris, B., Quail, M. A., Achtman, M., Atkin, R., Baker, S., Basham, D., Bason, N., Cherevach, I., Chillingworth, T., Collins, M., Cronin, A., Davis, P., Doggett, J., Feltwell, T., Goble, A., Hamlin, N., Hauser, H., Holroyd, S., Jagels, K., Leather, S., Moule, S., Norberczak, H., O'Neil, S., Ormond, D., Price, C., Rabbinowitsch, E., Rutter, S., Sanders, M., Saunders, D., Seeger, K., Sharp, S., Simmonds, M., Skelton, J., Squares, R., Squares, S., Stevens, K., Unwin, L., Whitehead, S., Barrell, B. G., & Maskell, D. J.
Affiliations
  • Wellcome Sanger Institute (GB)
  • University of Cambridge (GB)
  • Drew University (US)
  • Max Planck Institute for Infection Biology (DE)
Corresponding author
  • Parkhill, Julian
  • Maskell, Duncan J
ORCID
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2003-08-10
Volume
35
Issue
1
Pages
32-40
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng1227
OpenAlex
W2155534524
Cited by
1,037
References
53
Citations by year
2026: 24 · 2025: 36 · 2024: 26 · 2023: 28 · 2022: 31 · 2021: 40 · 2020: 29 · 2019: 45 · 2018: 30 · 2017: 40 · 2016: 32 · 2015: 61 · 2014: 61 · 2013: 37 · 2012: 42
FWCI
47.55
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords
Bordetella pertussis, Bordetella parapertussis, Bordetella bronchiseptica, genome sequencing, comparative genomics, bacterial evolution, gene loss, host adaptation, virulence, Betaproteobacteria, respiratory pathogens
MeSH terms
Base Sequence, Bordetella, Bordetella pertussis, DNA, Bacterial, Molecular Sequence Data, Species Specificity, Genome, Bacterial, Bordetella bronchiseptica, Sequence Analysis, DNA

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