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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Clinical Implications of Azole Resistance in Aspergillus fumigatus, the Netherlands, 2007–2009

Open access
van der Linden, Jan W.M., Snelders, Eveline, Kampinga, Greetje A., Rijnders, Bart J.A., Mattsson, Eva, Debets-Ossenkopp, Yvette J., Kuijper, Ed J, Van Tiel, Frank H., Melchers, Willem J.G., Verweij, Paul E.·2011·Emerging Infectious Diseases

Abstract

The prevalence and spread of azole resistance in clinical Aspergillus fumigatus isolates in the Netherlands are currently unknown. Therefore, we performed a prospective nationwide multicenter surveillance study to determine the effects of resistance on patient management strategies and public health. From June 2007 through January 2009, all clinical Aspergillus spp. isolates were screened for itraconazole resistance. In total, 2,062 isolates from 1,385 patients were screened; the prevalence of itraconazole resistance in A. fumigatus in our patient cohort was 5.3% (range 0.8%-9.5%). Patients with a hematologic or oncologic disease were more likely to harbor an azole-resistant isolate than were other patient groups (p<0.05). Most patients (64.0%) from whom a resistant isolate was identified were azole naive, and the case-fatality rate of patients with azole-resistant invasive aspergillosis was 88.0%. Our study found that multiazole resistance in A. fumigatus is widespread in the Netherlands and is associated with a high death rate for patients with invasive aspergillosis.

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Metadata

Authors
van der Linden, J. W. M., Snelders, E., Kampinga, G. A., Rijnders, B. J. A., Mattsson, E., Debets-Ossenkopp, Y. J., Kuijper, E. J., Van Tiel, F. H., Melchers, W. J. G., & Verweij, P. E.
Venue
Emerging Infectious Diseases
Published
2011-10
Volume
17
Issue
10
Pages
1846-1854
ISSN
  • 1080-6040 (ISSN-L)
  • 1080-6059
OpenAlex
W2104743902
Cited by
446
References
6
FWCI
20.22
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Clinical Implications of Azole Resistance in Aspergillus fumigatus, the Netherlands, 2007–2009. https://app.cochat.ai/papers/10.3201/eid1710.110226
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van der Linden, J. W. M., Snelders, E., Kampinga, G. A., Rijnders, B. J. A., Mattsson, E., Debets-Ossenkopp, Y. J., Kuijper, E. J., Van Tiel, F. H., Melchers, W. J. G., & Verweij, P. E. (2011). Clinical Implications of Azole Resistance in Aspergillus fumigatus, the Netherlands, 2007–2009. Emerging Infectious Diseases. https://doi.org/10.3201/eid1710.110226

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.