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Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment
Open accessAbstract
The era of iatrogenic Creutzfeldt-Jakob disease (CJD) has nearly closed; only occasional cases with exceptionally long incubation periods are still appearing. The principal sources of these outbreaks are contaminated growth hormone (226 cases) and dura mater grafts (228 cases) derived from human cadavers with undiagnosed CJD infections; a small number of additional cases are caused by neurosurgical instrument contamination, corneal grafts, gonadotrophic hormone, and secondary infection with variant CJD transmitted by transfusion of blood products. No new sources of disease have been identified, and current practices, which combine improved recognition of potentially infected persons with new disinfection methods for fragile surgical instruments and biological products, should continue to minimize the risk for iatrogenic disease until a blood screening test for the detection of preclinical infection is validated for human use.
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Citations
Cited by
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2013) · Nature · doi:10.1038/nature12481 · Cited by 1,663
Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy
Jaunmuktane, Z., Mead, S., Ellis, M., Wadsworth, J. D. F., Nicoll, A. J., Kenny, J., Launchbury, F., Linehan, J., Richard-Loendt, A., Walker, A. S., et al. (2015) · Nature · doi:10.1038/nature15369 · Cited by 518
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0238-6 · Cited by 450
Neurodegenerative Diseases: Expanding the Prion Concept
Walker, L. C., & Jucker, M. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033828 · Cited by 361
A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings
Orrú, C. D., Bongianni, M., Tonoli, G., Ferrari, S., Hughson, A. G., Groveman, B. R., Fiorini, M., Pocchiari, M., Monaco, S., Caughey, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315200 · Cited by 355
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Metadata
- Authors
- Brown, P., Brandel, J.-P., Sato, T., Nakamura, Y., MacKenzie, J., Will, R. G., Ladogana, A., Pocchiari, M., Leschek, E. W., & Schonberger, L. B.
- Venue
- Emerging Infectious Diseases
- Published
- 2012-06
- Volume
- 18
- Issue
- 6
- Pages
- 901-907
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- OpenAlex
- W2079304641
- Cited by
- 361
- References
- 0
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Brown, P., Brandel, J.-P., Sato, T., Nakamura, Y., MacKenzie, J., Will, R. G., Ladogana, A., Pocchiari, M., Leschek, E. W., & Schonberger, L. B. (2012). Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment. Emerging Infectious Diseases. https://doi.org/10.3201/eid1806.120116
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