Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy
Open accessAbstract
More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of treatment, typically in childhood, with human cadaveric pituitary-derived growth hormone contaminated with prions. Although such treatment ceased in 1985, iatrogenic CJD (iCJD) continues to emerge because of the prolonged incubation periods seen in human prion infections. Unexpectedly, in an autopsy study of eight individuals with iCJD, aged 36-51 years, in four we found moderate to severe grey matter and vascular amyloid-β (Aβ) pathology. The Aβ deposition in the grey matter was typical of that seen in Alzheimer's disease and Aβ in the blood vessel walls was characteristic of cerebral amyloid angiopathy and did not co-localize with prion protein deposition. None of these patients had pathogenic mutations, APOE ε4 or other high-risk alleles associated with early-onset Alzheimer's disease. Examination of a series of 116 patients with other prion diseases from a prospective observational cohort study showed minimal or no Aβ pathology in cases of similar age range, or a decade older, without APOE ε4 risk alleles. We also analysed pituitary glands from individuals with Aβ pathology and found marked Aβ deposition in multiple cases. Experimental seeding of Aβ pathology has been previously demonstrated in primates and transgenic mice by central nervous system or peripheral inoculation with Alzheimer's disease brain homogenate. The marked deposition of parenchymal and vascular Aβ in these relatively young patients with iCJD, in contrast with other prion disease patients and population controls, is consistent with iatrogenic transmission of Aβ pathology in addition to CJD and suggests that healthy exposed individuals may also be at risk of iatrogenic Alzheimer's disease and cerebral amyloid angiopathy. These findings should also prompt investigation of whether other known iatrogenic routes of prion transmission may also be relevant to Aβ and other proteopathic seeds associated with neurodegenerative and other human diseases.
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Human-to-human transmission of amyloid pathology is possible.
“There is strong evidence that human-to-human transmission of amyloid pathology is possible.”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as Jaunmuktane et al., 2015
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Cites
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859 · see citing works
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works
Prion Diseases of Humans and Animals: Their Causes and Molecular Basis
Collinge, J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.519 · Cited by 1,344 · see citing works
Self-citationA General Model of Prion Strains and Their Pathogenicity
Collinge, J., & Clarke, A. R. (2007) · Science · doi:10.1126/science.1138718 · Cited by 1,058 · see citing works
Self-citationExogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., Neuenschwander, A., Abramowski, D., Frey, P., Jaton, A. L., et al. (2006) · Science · doi:10.1126/science.1131864 · Cited by 971 · see citing works
Rowe, C. C., Ackerman, U., Browne, W. F., Mulligan, R. S., Pike, K. E., O'Keefe, G. J., Tochon‐Danguy, H., Chan, G., Berlangieri, S. U., Jones, G. R., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70001-2 · Cited by 671 · see citing works
Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study
Vonsattel, J. P. G., Myers, R. H., Tessa Hedley‐Whyte, E., Ropper, A. H., Bird, E. D., & Richardson, E. P. (1991) · Annals of Neurology · doi:10.1002/ana.410300503 · Cited by 662 · see citing works
Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis
Eisele, Y. S., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S. A., Wolburg, H., Walker, L. C., Staufenbiel, M., Heikenwalder, M., & Jucker, M. (2010) · Science · doi:10.1126/science.1194516 · Cited by 568 · see citing works
Kuru in the 21st century—an acquired human prion disease with very long incubation periods
Collinge, J., Whitfield, J., McKintosh, E., Beck, J., Mead, S., Thomas, D. J., & Alpers, M. P. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68930-7 · Cited by 427 · see citing works
Self-citationIatrogenic Creutzfeldt-Jakob Disease, Final Assessment
Brown, P., Brandel, J., SATO, T. A., Nakamura, Y., MacKenzie, J. M., Will, R. G., Ladogana, A., Pocchiari, M., Leschek, E., & Schonberger, L. B. (2012) · Emerging infectious diseases · doi:10.3201/eid1806.120116 · Cited by 360 · see citing works
Bolmont, T., Clavaguera, F., Meyer-Luehmann, M., Herzig, M. C., Radde, R., Staufenbiel, M., Lewis, J., Hutton, M., Tolnay, M., & Jucker, M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070403 · Cited by 281 · see citing works
Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
Eisele, Y. S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L. H., Yan, Z.-X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903200106 · Cited by 279 · see citing works
Risk Factors and Preventive Interventions for Alzheimer Disease
Daviglus, M. L., Plassman, B. L., Pirzada, A., Bell, C. C., Bowen, P. E., Burke, J. R., Connolly, E. S., Dunbar‐Jacob, J. M., Granieri, E. C., McGarry, K. M., et al. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.100 · Cited by 252 · see citing works
Parchi, P., de Boni, L., Saverioni, D., Cohen, M. L., Ferrer, I., Gambetti, P. L., Gelpí, E., Giaccone, G., Hauw, J., Höftberger, R., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1002-8 · Cited by 228 · see citing works
Irwin, D. J., Abrams, J. Y., Schonberger, L. B., Leschek, E., Mills, J. L., Lee, V. M. ‐., & Trojanowski, J. Q. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1933 · Cited by 167 · see citing works
Gajdusek, D. C. (1988) · Journal of Neuroimmunology · doi:10.1016/0165-5728(88)90140-3 · Cited by 151 · see citing works
Induction of β(A4)-amyloid in primates by injection of Alzheimer’s disease brain homogenate
Baker, H. F., Ridley, R. M., Duchen, L. W., Crow, T. J., & Bruton, C. J. (1994) · Molecular Neurobiology · doi:10.1007/bf02778005 · Cited by 149 · see citing works
Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease
Hainfellner, J., Wanschitz, J., Jellinger, K., Liberski, P., Gullotta, F., & Budka, H. (1998) · Acta Neuropathologica · doi:10.1007/s004010050870 · Cited by 146 · see citing works
Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice
Clavaguera, F., Hench, J., Lavenir, I., Schweighauser, G., Frank, S., Goedert, M., & Tolnay, M. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1231-5 · Cited by 143 · see citing works
Neuropathology: A Reference Text of CNS Pathology
Ellison, D. (1998) · Cited by 141 · see citing works
Seeded strain‐like transmission of β‐amyloid morphotypes in APP transgenic mice
Heilbronner, G., Eisele, Y. S., Langer, F., Kaeser, S. A., Novotny, R., Nagarathinam, A., Åslund, A., Hammarström, P., Nilsson, K. P. R., & Jucker, M. (2013) · EMBO Reports · doi:10.1038/embor.2013.137 · Cited by 139 · see citing works
Rudge, P., Jaunmuktane, Z., Adlard, P., Bjurstrom, N., Caine, D., Lowe, J., Norsworthy, P. J., Hummerich, H., Druyeh, R., Wadsworth, J. D. F., et al. (2015) · Brain · doi:10.1093/brain/awv235 · Cited by 115 · see citing works
Self-citationHamaguchi, T., Eisele, Y. S., Varvel, N. H., Lamb, B. T., Walker, L. C., & Jucker, M. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0912-1 · Cited by 100 · see citing works
van der Laak, J. A. W. M., Pahlplatz, M. M. M., Hanselaar, A. G. J. M., & de Wilde, P. C. M. (2000) · Cytometry · doi:10.1002/(sici)1097-0320(20000401)39:4 · Cited by 91 · see citing works
Brandner, S., Whitfield, J. T., Boone, K., Puwa, A., O'Malley, C., Linehan, J. M., Joiner, S., Scaravilli, F., Calder, I., Alpers, M. P., et al. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0091 · Cited by 72 · see citing works
Self-citationCreutzfeldt-Jakob disease in United Kingdom patients treated with human pituitary growth hormone
Swerdlow, A. J., Higgins, C. D., Adlard, P., Jones, M. E., & Preece, M. A. (2003) · Neurology · doi:10.1212/01.wnl.0000084000.27403.15 · Cited by 71 · see citing works
PrP glycoforms are associated in a strain-specific ratio in native PrPSc
Khalili-Shirazi, A., Summers, L. E., Linehan, J. M., Mallinson, G., Anstee, D. J., Hawke, S. H., Jackson, G. S., & Collinge, J. (2005) · Journal of General Virology · doi:10.1099/vir.0.80375-0 · Cited by 70 · see citing works
Self-citationAβ seeds resist inactivation by formaldehyde
Fritschi, S. K., Cintron, A. F., Ye, L., Mahler, J., Bühler, A., Baumann, F., Neumann, M., Nilsson, K. P. R., Hammarström, P., Walker, L. C., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1339-2 · Cited by 68 · see citing works
Validation of next-generation sequencing technologies in genetic diagnosis of dementia
Beck, J., Pittman, A. M., Adamson, G., Campbell, T., Kenny, J., Houlden, H., Rohrer, J. D., de Silva, R., Shoai, M., Uphill, J. B., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.017 · Cited by 64 · see citing works
Self-citationBeekes, M., Thomzig, A., Schulz‐Schaeffer, W., & Burger, R. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1324-9 · Cited by 64 · see citing works
Neuropathology: A Reference Text of CNS Pathology
Crain, B. J. (1999) · Archives of Pathology & Laboratory Medicine · doi:10.5858/1999-123-445a-nartoc · Cited by 63 · see citing works
Preusser, M. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.070805 · Cited by 51 · see citing works
Molecular Diagnosis of Human Prion Disease
Wadsworth, J. D. F., Powell, C., Beck, J. A., Joiner, S., Linehan, J. M., Brandner, S., Mead, S., & Collinge, J. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-234-2_14 · Cited by 45 · see citing works
Self-citationHeyman, A., Fillenbaum, G. G., & Mirra, S. S. (1990) · Aging Clinical and Experimental Research · doi:10.1007/bf03323962 · Cited by 37 · see citing works
Lack of TAR‐DNA binding protein‐43 (TDP‐43) pathology in human prion diseases
Isaacs, A. M., Powell, C., Webb, T., Linehan, J. M., Collinge, J., & Brandner, S. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00963.x · Cited by 26 · see citing works
Self-citationAbrams, J. Y., Schonberger, L. B., Belay, E. D., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1357 · Cited by 25 · see citing works
Alzheimer’s Disease and History of Blood Transfusion by Apolipoprotein-E Genotype
O'Meara, E. S., Kukull, W. A., Schellenberg, G. D., Bowen, J. D., McCormick, W. C., Teri, L. L., Pfanschmidt, M. L., Thompson, J. D., & Larson, E. B. (1997) · Neuroepidemiology · doi:10.1159/000109675 · Cited by 19 · see citing works
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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204 · see citing works
Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125 · see citing works
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Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676 · see citing works
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Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0281-2 · Cited by 947 · see citing works
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Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808 · see citing works
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Peng, C., Trojanowski, J. Q., & Lee, V. M.-Y. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0333-7 · Cited by 625 · see citing works
Lee, S. J. C., Nam, E., Lee, H. J., Savelieff, M. G., & Lim, M. H. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00731g · Cited by 576 · see citing works
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- Authors
- Jaunmuktane, Z., Mead, S., Ellis, M., Wadsworth, J. D. F., Nicoll, A. J., Kenny, J., Launchbury, F., Linehan, J., Richard-Loendt, A., Walker, A. S., Rudge, P., Collinge, J., & Brandner, S.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- MRC Prion Unit (GB)
- MRC Clinical Trials Unit at UCL (GB)
- Corresponding author
- Collinge, John
- Brandner, Sebastian
- ORCID
- Venue
- Nature
- Published
- 2015-09-09
- Volume
- 525
- Issue
- 7568
- Pages
- 247-250
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1846679411
- Cited by
- 518
- References
- 41
- Citations by year
- 2026: 23 · 2025: 31 · 2024: 39 · 2023: 38 · 2022: 37 · 2021: 38 · 2020: 59 · 2019: 55 · 2018: 50 · 2017: 58 · 2016: 74 · 2015: 16
- FWCI
- 28.64
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-09-16)
- Open access
- bronze
- doi.org
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- National Institute for Health and Care Research
- University College London Hospitals NHS Foundation Trust
- Medical Research Council (MC_UU_12023/22)
- UCLH Biomedical Research Centre
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- iatrogenic Creutzfeldt-Jakob disease, amyloid-beta pathology, cerebral amyloid angiopathy, Alzheimer's disease, human growth hormone, iatrogenic transmission, prion infection, long incubation period
- MeSH terms
- Adult, Alleles, Alzheimer Disease, Autopsy, Blood Vessels, Drug Contamination, Endothelium, Vascular, Humans, Iatrogenic Disease, Creutzfeldt-Jakob Syndrome, Middle Aged, Prions, Risk Factors, Case-Control Studies, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Human Growth Hormone, Gray Matter
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