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Multidrug-Resistant Salmonella enterica Serotype Typhi, Gulf of Guinea Region, Africa
Open accessAbstract
We identified 3 lineages among multidrug-resistant (MDR) Salmonella enterica serotype Typhi isolates in the Gulf of Guinea region in Africa during the 2000s.However, the MDR H58 haplotype, which predominates in southern Asia and Kenya, was not identified.MDR quinolone-susceptible isolates contained a 190-kb incHI1 pST2 plasmid or a 50-kb incN pST3 plasmid. Multidrug-Resistant Salmonella enterica Serotype Typhi, Gulf of Guinea Region, Africa
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In the past two decades, multidrug-resistant Salmonella Typhi has emerged and spread throughout the sub-Saharan Africa region.
“in the past two decades, multidrug-resistant (defined as resistance to ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol) S. Typhi has emerged and spread throughout the region.”
From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [66]
The Study (page unavailable) reports that MDR S. Typhi isolates acquired in Africa increased from 0% in 1996–1999 to 22.3% in 2010–2013, and the Conclusions document emerging lineages in the Gulf of Guinea area. This supports emergence over roughly two decades, but not spread throughout sub-Saharan Africa. The Study also defines MDR as resistance to at least two of four listed drugs, rather than resistance to all three drugs specified in the citing sentence. (LLM, conf=0.89)
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References 18 · Cited by 26
Research works printed but not linked: 14
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Metadata
- Authors
- Baltazar, M., Ngandjio, A., Holt, K. E., Lepillet, E., Pardos de la Gandara, M., Collard, J.-M., Bercion, R., Nzouankeu, A., Le Hello, S., Dougan, G., Fonkoua, M.-C., & Weill, F.-X.
- Affiliations
- Université de Limoges (FR)
- Institut Pasteur (FR)
- Institut Pasteur de Dakar (SN)
- Corresponding author
- Weill, François-Xavier
- ORCID
- Venue
- Emerging Infectious Diseases
- Published
- 2015-04
- Volume
- 21
- Issue
- 4
- Pages
- 655-659
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC4378479
- OpenAlex
- W2318342779
- Cited by
- 26
- References
- 18
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Zaguan (University of Zaragoza Repository) (publishedVersion, other-oa)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (10-LABX-62-IBEID, ANR‐10‐LABX‐62‐IBEID, ANR-10, ANR-10-LABX-0062, grant ANR-10-LABX-62-IBEID, ANR-10-LABX-62)
- Institut de Veille Sanitaire
- Université de Limoges
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Salmonella typhi, multidrug resistance, antimicrobial resistance, IncHI1 plasmids, IncN plasmids, plasmid typing, quinolone susceptibility, Gulf of Guinea
- MeSH terms
- Anti-Bacterial Agents, Geography, Haplotypes, Humans, Microbial Sensitivity Tests, Salmonella typhi, Typhoid Fever, Genetic Variation, Guinea, Polymorphism, Single Nucleotide, Drug Resistance, Multiple, Bacterial
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