Recognition of Azole-Resistant Aspergillosis by Physicians Specializing in Infectious Diseases, United States
Open accessAbstract
Infections caused by pan-azole-resistant Aspergillus fumigatus strains have emerged in Europe and recently in the United States.Physicians specializing in infectious diseases reported observing pan-azole-resistant infections and low rates of susceptibility testing, suggesting the need for wider-scale testing. I nfections with strains ofAspergillus fumigatus that are resistant to all azole antifungal medications have become common in western Europe and have been documented in other regions since 1998 (1,2), but until recently, had Recognition of Azole-Resistant Aspergillosis by Physicians Specializing in Infectious Diseases, United States Emerging Infectious Diseases • www.cdc.gov/eid• Vol. 24, No. 1, January 2018 111 In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases.Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.Medscape, LLC designates this Journal-based CME activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™.Physicians should claim only the credit commensurate with the extent of their participation in the activity.All other clinicians completing this activity will be issued a certificate of participation.To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 75% minimum passing score and complete the evaluation at http://www.medscape.org/journal/eid;and (4) view/print certificate.For CME questions, see page 190.
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Pan-azole-resistant A. fumigatus is increasingly reported in Europe and the USA, and intrinsic triazole resistance is higher among cryptic Aspergillus species.
“While resistance rates remain generally favorable amongst common Aspergillus species (A. fumigatus, A. flavus, A. versicolor, etc.), pan-azole-resistant A. fumigatus is increasingly reported in Europe and the USA, and intrinsic triazole resistance is higher amongst cryptic species [12].”
From Investigational Agents for the Treatment of Resistant Yeasts and Molds (2021) · cites this paper as [12]
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Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?
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Clinical Implications of Azole Resistance inAspergillus fumigatus, the Netherlands, 2007–2009
van der Linden, J. W. M., Snelders, E., Kampinga, G. A., Rijnders, B. J. A., Mattsson, E., Debets-Ossenkopp, Y. J., Kuijper, E. J., van Tiel, F. H., Melchers, W. J. G., & Verweij, P. E. (2011) · Emerging infectious diseases · doi:10.3201/eid1710.110226 · Cited by 445 · see citing works
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Passive Surveillance for Azole-ResistantAspergillus fumigatus, United States, 2011–2013
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Self-citationEmergence of Azole Resistance in Aspergillus
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Research works printed but not linked: 1
- [3]Wiederhold NP, Garcia Gil V, Lindner J, Sanders C, Fan H, Sutton A, et al. Evaluation of Cyp51A mechanisms of azole resistance in Aspergillus fumigatus isolates from the United States. Mycoses. 2015; 58: 55.
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Investigational Agents for the Treatment of Resistant Yeasts and Molds
Seiler, G. T., & Ostrosky-Zeichner, L. (2021) · Current Fungal Infection Reports · doi:10.1007/s12281-021-00419-5 · Cited by 32 · see citing works
- Authors
- Walker, T. A., Lockhart, S. R., Beekmann, S. E., Polgreen, P. M., Santibanez, S., Mody, R. K., Beer, K. D., Chiller, T. M., & Jackson, B. R.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Walker, Tiffany A.
- ORCID
- Venue
- Emerging Infectious Diseases
- Published
- 2018-01
- Volume
- 24
- Issue
- 1
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC5749442
- OpenAlex
- W2772011987
- Cited by
- 13
- References
- 12
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institute of Environmental Science and Research
- Centers for Disease Control and Prevention (U50 CK000477, 1 U50 CK000477)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- invasive aspergillosis, azole resistance, antifungal susceptibility testing, physician awareness, emerging fungal infections, United States
- MeSH terms
- Antifungal Agents, Aspergillosis, Aspergillus fumigatus, Azoles, Humans, Microbial Sensitivity Tests, United States, Drug Resistance, Fungal, Infectious Disease Medicine, Voriconazole
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