Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition
Open accessAbstract
Plaque formation due to amyloid-β oligomerization and fibrillation is a key issue for its deposition in the brains of dementia and Alzheimer’s disease patients. Related drugs preventing this peptide fibril accumulation bear the potential of considerable medical and social value. In this study, we performed in vitro fibrillation inhibition tests with eight different medical plant extracts and nutraceuticals using fluorescence spectroscopy. Successful inhibition of the following plant extracts and nutraceuticals were obtained: Withania somnifera, Centella asiatica, Bacopa monnieri, and Convolvulus pluricaulis, providing new drug candidates for the prevention and treatment of Alzheimer’s disease.
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Asiaticosides in Centella asiatica extract are the most potent inhibitor of Aβ40 and MAβ40 fibrillation and interact with MAβ40.
“It was observed that the asiaticosides present in CA extract act as the most potent inhibitor, which was found to interact with MAb40 [109].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [109]
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References 67 · Cited by 25
- Authors
- Witter, S., Witter, R., Vilu, R., & Samoson, A.
- Affiliations
- Tallinn University of Technology (EE)
- Karlsruhe Institute of Technology (DE)
- Competence Center of Food and Fermentation Technology (TFTAK), Tallinn, Estonia
- Corresponding author
- Witter, Steffi
- Venue
- Journal of Alzheimer s Disease Reports
- Publisher
- SAGE Publications
- Published
- 2018-03-06
- Volume
- 2
- Issue
- 1
- Pages
- 239-252
- ISSN
- 2542-4823 (ISSN-L)
- PMC
- PMC6311354
- OpenAlex
- W2906011770
- Cited by
- 25
- References
- 67
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 3
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease Reports (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Eesti Teadusagentuur (PUT126, IUT19-27, PUT1534)
- Tallinna Tehnikaülikool (PUT1534, PUT126, IUT 1927)
- European Regional Development Fund (2016-2022)
- European Social Fund (2014-20)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- plant extracts, nutraceuticals, Alzheimer's disease, amyloid plaques, Withania somnifera, Centella asiatica, Bacopa monnieri, Convolvulus pluricaulis, dementia
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