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Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease
Open accessAbstract
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer’s disease dementia (AD)) as an ‘Inception cohort’ who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an ‘Enrichment cohort’ (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations. Results: AIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression. Conclusion: This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims.
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“The Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging is a longitudinal study of over 1,117 volunteers and includes amyloid positron emission tomography (PET) imagining, as well as several repeated cognitive and behavioral tests [24].”
From Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [24]
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Metadata
- Authors
- Fowler, C., Rainey-Smith, S. R., Bird, S., Bomke, J., Bourgeat, P., Brown, B. M., Burnham, S. C., Bush, A. I., Chadunow, C., Collins, S., Doecke, J., Doré, V., Ellis, K. A., Evered, L., Fazlollahi, A., Fripp, J., Gardener, S. L., Gibson, S., Grenfell, R., Harrison, E., Head, R., Jin, L., Kamer, A., Lamb, F., Lautenschlager, N. T., Laws, S. M., Li, Q.-X., Lim, L., Lim, Y. Y., Louey, A., Macaulay, S. L., Mackintosh, L., Martins, R. N., Maruff, P., Masters, C. L., McBride, S., Milicic, L., Peretti, M., Pertile, K., Porter, T., Radler, M., Rembach, A., Robertson, J., Rodrigues, M., Rowe, C. C., Rumble, R., Salvado, O., Savage, G., Silbert, B., Soh, M., Sohrabi, H. R., Taddei, K., Taddei, T., Thai, C., Trounson, B., Tyrrell, R., Vacher, M., Varghese, S., Villemagne, V. L., Weinborn, M., Woodward, M., Xia, Y., Ames, D., & the AIBL investigators
- Affiliations
- The University of Melbourne (AU)
- Centre of Excellence for Alzheimer’s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Murdoch University (AU)
- Department of Anaesthesia and Acute Pain Medicine, St Vincent’s Hospital Melbourne, Victoria Parade, Fitzroy, VIC, Australia
- Australian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia
- Austin Hospital (AU)
- Cogstate Limited, Melbourne, VIC, Australia
- Macquarie University (AU)
- St Vincent's Hospital Melbourne (AU)
- University of Pittsburgh (US)
- Corresponding author
- Masters, Colin L.
- ORCID
- Fowler, Christopher
- Bomke, Julia
- Bourgeat, Pierrick
- Brown, Belinda M.
- Burnham, Samantha C.
- Bush, Ashley I.
- Collins, Steven
- Doecke, James
- Doré, Vincent
- Ellis, Kathryn A.
- Fazlollahi, Amir
- Gardener, Samantha L.
- Head, Richard
- Jin, Liang
- Lautenschlager, Nicola T.
- Laws, Simon M.
- Li, Qiao-Xin
- Lim, Yen Ying
- Macaulay, S. Lance
- Mackintosh, Lucy
- Martins, Ralph N.
- Maruff, Paul
- Masters, Colin L.
- McBride, Simon
- Milicic, Lidija
- Peretti, Madeline
- Porter, Tenielle
- Rodrigues, Mark
- Rowe, Christopher C.
- Salvado, Olivier
- Savage, Greg
- Silbert, Brendan
- Sohrabi, Hamid R.
- Taddei, Kevin
- Vacher, Michael
- Villemagne, Victor L.
- Weinborn, Michael
- Xia, Ying
- Venue
- Journal of Alzheimer's Disease Reports
- Publisher
- SAGE Publications
- Published
- 2021-03-11
- Volume
- 5
- Issue
- 1
- Pages
- 443-468
- ISSN
- 2542-4823 (ISSN-L)
- PMC
- PMC8293663
- OpenAlex
- W3167322081
- Cited by
- 164
- References
- 127
- Citations by year
- 2026: 27 · 2025: 42 · 2024: 41 · 2023: 21 · 2022: 30 · 2021: 3
- FWCI
- 17.03
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by-nc)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc)
- Murdoch University Research Portal (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by-nc)
- Australasian Journal of Paramedicine (submittedVersion, cc-by-nc)
- Edith Cowan University Research Online (Edith Cowan University) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Elan
- Avid Radiopharmaceuticals
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, mild cognitive impairment, preclinical Alzheimer's disease, prodromal Alzheimer's disease, amyloid PET, tau PET, blood biomarkers, neuroimaging, cognitive decline, older adults, longitudinal cohort, disease progression, age of onset
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