The Correlation of Plasma Proteins Binding Capacity and Flavopiridol Cellular and Clinical Trial Studies
Open accessAbstract
Previous clinical research has suggested high-affinity binding of flavopiridol (FLAP) to human blood serum proteins, specifically either human serum albumin (HSA) or human alpha-1-acid glycoprotein (hAGP), when compared to fetal bovine serum albumin
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A final HSA concentration of 600 μM mimics physiological conditions.
“One side of each dialysis cell was dosed with 7.97 mg HSA (≤0.02% fatty acids, Sigma-Aldrich, Munich, Germany) in phosphate-buffered saline (PBS, pH 7.4 prepared in HPLC grade water) to a final concentration of 600 μM, which mimics physiological conditions [30].”
From In-Vitro and In-Silico Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film-Forming Foam (AFFF) Binding to Human Serum Albumin (2021) · cites this paper as [30]
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Cites
Structural Basis of the Drug-binding Specificity of Human Serum Albumin
Ghuman, J., Zunszain, P. A., Petitpas, I., Bhattacharya, A. A., Otagiri, M., & Curry, S. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.07.075 · Cited by 1,941 · see citing works
Drug binding to human alpha-1-acid glycoprotein in health and disease.
Kremer, J. M., Wilting, J., & Janssen, L. H. M. (1988) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00015-8 · Cited by 584 · see citing works
Byrd, J. C., Lin, T. S., Dalton, J. T., Wu, D., Phelps, M. A., Fischer, B., Moran, M. E., Blum, K. A., Rovin, B. H., Brooker-McEldowney, M., et al. (2006) · Blood · doi:10.1182/blood-2006-05-020735 · Cited by 393 · see citing works
The plasma proteins : structure, function, and genetic control
Putnam, F. W. (1975) · Cited by 391 · see citing works
Dam, J., & Schuck, P. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)84012-6 · Cited by 299 · see citing works
Byrd, J. C., Shinn, C. A., Waselenko, J. K., et al. (1998) · Blood · doi:10.1182/blood.v92.10.3804 · Cited by 282 · see citing works
Regulation of Hsp90 ATPase Activity by the Co-chaperone Cdc37p/p50
Siligardi, G., Panaretou, B., Meyer, P., Singh, S., Woolfson, D. N., Piper, P. W., Pearl, L. H., & Prodromou, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201287200 · Cited by 272 · see citing works
Schwartz, G. K., O'Reilly, E. M., Ilson, D. H., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.08.080 · Cited by 156 · see citing works
Tan, A. R., Headlee, D. J., Messmann, R. A., Sausville, E. A., Arbuck, S. G., Murgo, A. J., Melillo, G., Zhai, S., Figg, W. D., Swain, S. M., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.01.043 · Cited by 119 · see citing works
Hussain, R., Benning, K., Jávorfí, T., et al. (2015) · Journal of Synchrotron Radiation · doi:10.1107/s1600577514028161 · Cited by 77 · see citing works
Flavopiridol in Chronic Lymphocytic Leukemia: A Concise Review
Christian, B. A., Grever, M. R., Byrd, J. C., et al. (2009) · Clinical Lymphoma & Myeloma · doi:10.3816/clm.2009.s.009 · Cited by 43 · see citing works
Hussain, R., Benning, K., Myatt, D. P., et al. (2015) · Journal of Synchrotron Radiation · doi:10.1107/s1600577515007602 · Cited by 21 · see citing works
Self-citationPhelps, M. A., Rozewski, D. M., Johnston, J. S., et al. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.04.023 · Cited by 17 · see citing works
Tognon, G., Frapolli, R., Zaffaroni, M., et al. (2003) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0704-y · Cited by 14 · see citing works
Evaluation of Human Plasma Protein Binding of Trabectedin (Yondelis™, ET-743)
Beumer, J. H., Lázaro, L. L., Schellens, J. H. M., et al. (2009) · Current Clinical Pharmacology · doi:10.2174/157488409787236047 · Cited by 13 · see citing works
The binding of flavopiridol to blood serum albumin
Myatt, D. P., Johnson, L., Baumli, S., et al. (2010) · Chirality · doi:10.1002/chir.20925 · Cited by 9 · see citing works
Self-citationIsothermal Titration Calorimetry Characterization of Drug-Binding Energetics to Blood Proteins
Caldwell, G. W., & Yan, Z. (2004) · Humana Press eBooks · doi:10.1385/1-59259-800-5:123 · Cited by 9 · see citing works
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Research works printed but not linked: 3
- M.E. Burton, L. Shaw, J.J. Schentag and W. Evans, Chapter 6, in: Applied Pharmacokinetics and Pharmacodynamics: Principles of Therapeutic Drug Monitoring, Lippincott Williams and Wilkins, 2005.
- T.J. Peters, All About Albumin, Academic Press, San Diego; New York [etc.], 1996.
- L. Shargel and A.B.C. Yu, Applied Biopharmaceutics & Pharmacokinetics, 7th edn, McGraw-Hill Education, New York, 2016.
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Li, W., Hu, Y., & Bischel, H. N. (2021) · Toxics · doi:10.3390/toxics9030063 · Cited by 53 · see citing works
“4 prepared in HPLC grade water) to a final concentration of 600 μM, which mimics physiological conditions [30].”
Background
- Authors
- Myatt, D. P.
- Affiliations
- Rutherford Appleton Laboratory (GB)
- Corresponding author
- Myatt, Daniel P.
- ORCID
- Myatt, Daniel P.
- Venue
- Biomedical Spectroscopy and Imaging
- Publisher
- IOS Press
- Published
- 2017-06-20
- Volume
- 6
- Issue
- 1-2
- Pages
- 59-73
- ISSN
- 2212-8794 (ISSN-L)
- 2212-8808
- OpenAlex
- W2618143041
- Cited by
- 10
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biomedical Spectroscopy and Imaging (publishedVersion)
- Science and Technology Facilities Council (submittedVersion)
- Funders
- Diamond Light Source
- University of Oxford
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- flavopiridol, protein binding capacity, human serum albumin, alpha-1-acid glycoprotein, drug-protein binding, plasma proteins, pharmacokinetics
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