Cited by 35Epigenetics and DNA MethylationAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Age-Dependent Increment of Hydroxymethylation in the Brain Cortex in the Triple-Transgenic Mouse Model of Alzheimer's Disease

Cadena-del-Castillo, Carla, Valdes-Quezada, Christian, Carmona-Aldana, Francisco, Arias, Clorinda, Bermúdez-Rattoni, Federico, Recillas-Targa, Félix·2014·Journal of Alzheimer's Disease

Abstract

Alzheimer's disease (AD) is a complex disorder whose etiology is associated with environmental and genetic factors. Recently there have been several attempts to analyze the role of epigenetic alterations in the origin and progression of this neurodegenerative condition. To evaluate the potential participation of the methylation status of the genome that may contribute to AD progression, we have studied the levels and distribution of the 5-methylcytosine and 5-hydroxymethylcytosine in different brain regions at different ages. We analyzed and quantified the immunosignal of these two epigenetic marks in young versus old wild-type mice and in the triple-transgenic mouse model of AD (3xTg-AD). The results show a decline in global 5-methylcytosine mark over time in all studied brain regions concomitant with a significant and widespread increase in 5-hydroxymethylcytosine mark in the aged transgenic mice in contrast to the age-matched controls. These differences in the methylation pattern of brain DNA in the 3xTg-AD that accumulates along age indicates abnormal formation of permissive chromatin structure associated with the increase in AD-related markers.

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Crossref · 10.3233/jad-132285

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Authors
Cadena-del-Castillo, C., Valdes-Quezada, C., Carmona-Aldana, F., Arias, C., Bermúdez-Rattoni, F., & Recillas-Targa, F.
Affiliations
  • Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., México
  • Universidad Nacional Autónoma de México (MX)
  • Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (MX)
  • Departamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., México
Venue
Journal of Alzheimer's Disease
Published
2014-07-16
Volume
41
Issue
3
Pages
845-854
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1640694777
Cited by
35
References
23
Citations by year
2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 5
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, 5-hydroxymethylcytosine
MeSH terms
Age Factors, Aging, Alzheimer Disease, Animals, Cerebral Cortex, Cytosine, Disease Models, Animal, Gene Expression Regulation, Genotype, Humans, Methylation, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, 5-Methylcytosine, Mice, Presenilin-1

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