Phenomenology of Depression in Alzheimer’s Disease
Open accessAbstract
Depression is among the most frequent psychiatric comorbid conditions in dementia. There is no strong consensus as to what criteria should be used to diagnose depression in AD. This is at least partially explained by the overlap between symptoms of depression and symptoms of AD. Recent studies using latent class analysis provided clarification to this diagnostic dilemma. All nine DSM-IV symptoms of major depression were found to characterize a class with a high chance (96% ) of having a clinical diagnosis of major depression, and symptoms of anxiety were also frequent. Other psychiatric symptoms may also be included under the construct of depression in AD, since both apathy and anxiety are among the most frequent comorbid conditions for major depression in AD. Subtypes of depression should also be validated in this condition. For instance, increased awareness of cognitive and functional deficits is significantly associated with dysthymia but not with major depression, suggesting that different depressive syndromes in AD may have different etiology.
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Patients suffering from AD are more prone to comorbid depression.
“Patients suffering from AD are more prone to comorbid depression [40, 41]”
From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [40]
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Banerjee, S., Hellier, J., Dewey, M., Romeo, R., Ballard, C., Baldwin, R., Bentham, P., Fox, C., Holmes, C., Katona, C., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60830-1 · Cited by 532 · see citing works
Porter, V. R., Buxton, W. G., Fairbanks, L. A., Strickland, T., O'Connor, S. M., Rosenberg-Thompson, S., & Cummings, J. L. (2003) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.15.2.180 · Cited by 182 · see citing works
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APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Fang, W., Xiao, N., Zeng, G., Bi, D., Dai, X., Mi, X., Ye, Q., Chen, X., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01631-0 · Cited by 42 · see citing works
- Authors
- Novais, F., & Starkstein, S.
- Affiliations
- Hospital de Santa Maria (PT)
- The University of Western Australia (AU)
- Corresponding author
- Starkstein, Sergio
- ORCID
- Novais, Filipa
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2015-08-11
- Volume
- 47
- Issue
- 4
- Pages
- 845-855
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2285813168
- Cited by
- 85
- References
- 2
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 13 · 2022: 14 · 2021: 14 · 2020: 12 · 2019: 3 · 2018: 9 · 2017: 3 · 2016: 5
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion, other-oa)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Depressive Disorder, Humans, Comorbidity
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