Frequency and Characteristics of Anxiety Among Patients With Alzheimer's Disease and Related Dementias
Open accessAbstract
The purpose of this study was to assess the cross-sectional prevalence and characteristics of anxiety among patients with Alzheimer's disease (AD), as compared with patients with frontotemporal dementia (FTD), patients with vascular dementia (VaD), and normal control subjects. The authors used the anxiety subscale of the Neuropsychiatric Inventory (NPI), an instrument with established reliability and validity, to compare patients. Patients were identified in a query of the UCLA Alzheimer's Disease Center database and included 115 patients with probable AD, 43 patients with VaD, 33 patients with FTD, and 40 normal, elderly control subjects. Descriptive statistics were generated, and partial correlations, controlling for Mini-Mental State Examination (MMSE) score, were performed between the anxiety subscale and other behavioral features as measured by the NPI and the Functional Activities Questionnaire (FAQ). Relationships between cognitive status (as indicated by MMSE score) and anxiety were explored. Anxiety was reported more commonly in patients with VaD and FTD than in patients with AD. These differences remained significant (P<0.01) in an analysis of variance (ANOVA) after adjusting for age, age at onset, educational level, and MMSE score. In AD, anxiety was inversely related to MMSE score (i.e., worse with more severe dementia), was more prevalent among patients with a younger age at onset (under age 65), and correlated with disability as measured by the FAQ score. These data suggest that anxiety is common among patients with diverse forms of dementia. In AD, anxiety is most common in those with more severe cognitive deterioration and an earlier age at onset.
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Self-citationFrontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Self-citationRomán, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Self-citationMeasurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978 · see citing works
The Neuropsychiatric Inventory
Cummings, J. L. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.10s · Cited by 2,017 · see citing works
Self-citationClinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331 · see citing works
Chui, H. C., Victoroff, J. I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R. (1992) · Neurology · doi:10.1212/wnl.42.3.473 · Cited by 1,201 · see citing works
The spectrum of behavioral changes in Alzheimer's disease
Mega, M., Cummings, J., Fiorello, T., & Gornbein, J. (1996) · Neurology · doi:10.1212/wnl.46.1.130 · Cited by 1,124 · see citing works
Self-citationAssessment of behavioral problems in dementia: The Revised Memory and Behavior Problems Checklist.
Teri, L. L., Truax, P. A., Logsdon, R. G., Uomoto, J. M., Zarit, S., & VITALIANO, P. P. (1992) · Psychology and Aging · doi:10.1037//0882-7974.7.4.622 · Cited by 1,117 · see citing works
A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease
Feldman, H., Gauthier, S. G., Hecker, J., Vellas, B. J., Subbiah, P., Whalen, E., & the Donepezil MSAD Study Investigators Group* (2001) · Neurology · doi:10.1212/wnl.57.4.613 · Cited by 600 · see citing works
To: A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease
(2001) · Neurology · doi:10.1212/wnl.57.11.2153-a · Cited by 490 · see citing works
Tariot, P. N., Mack, J. L., Patterson, M. B., Edland, S. D., Weiner, M., Fillenbaum, G. G., Blazina, L., Teri, L. L., Rubin, E. H., & Mortimer, J. A. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1349 · Cited by 425 · see citing works
Cholinesterase Inhibitors: A New Class of Psychotropic Compounds
Cummings, J. L. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.4 · Cited by 383 · see citing works
Self-citationThe Evolution of Psychiatric Symptoms in Alzheimer's Disease: A Natural History Study
Jost, B. C., & Grossberg, G. T. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb02942.x · Cited by 341 · see citing works
Alzheimer Disease and Frontotemporal Dementias
Levy, M. L. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550070129021 · Cited by 277 · see citing works
The Cholinergic Hypothesis of Neuropsychiatric Symptoms in Alzheimer's Disease
Cummings, J. L., & Back, C. (1998) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199821001-00009 · Cited by 274 · see citing works
Self-citationDeutch, A. Y., & Charney, D. S. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.70 · Cited by 260 · see citing works
Russo, J. E., VITALIANO, P. P., Brewer, D. D., Katon, W. J., & al, E. (1995) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.104.1.197 · Cited by 200 · see citing works
Psychiatric symptoms associated with Alzheimer's disease
Mendez, M. F., Martin, R. J., Smyth, K. A., & Whitehouse, P. J. (1990) · Journal of Neuropsychiatry · doi:10.1176/jnp.2.1.28 · Cited by 129 · see citing works
Sultzer, D. L., Levin, H. S., Mahler, M. E., High, W. M., & Cummings, J. L. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02101.x · Cited by 124 · see citing works
Self-citationNeuropsychiatric Symptoms and Cholinergic Therapy for Alzheimer’s Disease
Levy, M. L., Cummings, J. L., & Kahn-Rose, R. (1999) · Gerontology · doi:10.1159/000052760 · Cited by 121 · see citing works
Self-citationYates, W. R., & Gleason, O. C. (1998) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1998)7:4 · Cited by 81 · see citing works
Mendez, M. F., Perryman, K. M., Miller, B. L., & Cummings, J. L. (1998) · International Psychogeriatrics · doi:10.1017/s1041610298005262 · Cited by 62 · see citing works
Self-citationFrontotemporal Dementia and Alzheimer’s Disease:Differential Diagnosis
Duara, R., Barker, W., & Luis, C. A. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051210 · Cited by 53 · see citing works
Tractenberg, R. E., Patterson, M. B., Weiner, M., Teri, L. L., Grundman, M., Thomas, R. G., & Thal, L. J. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.4.472 · Cited by 31 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Harwood DG, Ownby RL, Barker WW, et al: The behavioral pa- thology in Alzheimer's disease scale (BEHAVE-AD): factor structure among community-dwelling Alzheimer's disease pa- tients. Int J Geriat Psychiatry 1998; 13:793-800
- Chemerinski E, Petracca G, Manes F, et al: Prevalence and cor- relates of anxiety in Alzheimer's disease. Depress Anxiety 1998; 7:166-170
- Cummings JL, Mega M, Gray K, et al: The Neuropsychiatric In- ventory: comprehensive assessment of psychopathology in de- mentia. Neurology 1994; 44:2308-2314
Cited by
Sorted by citations
The prevalence of anxiety in older adults: Methodological issues and a review of the literature
Bryant, C., Jackson, H., & Ames, D. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.11.008 · Cited by 511 · see citing works
Predictors of progression from mild cognitive impairment to Alzheimer disease
Palmer, K., Berger, A., Monastero, R., Winblad, B. G., Bäckman, L., & Fratiglioni, L. (2007) · Neurology · doi:10.1212/01.wnl.0000260968.92345.3f · Cited by 436 · see citing works
Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives
Ma, L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00009 · Cited by 323 · see citing works
Anxiety in dementia: A critical review
Seignourel, P. J., Kunik, M. E., Snow, L., WILSON, N. L., & Stanley, M. A. (2008) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.02.008 · Cited by 316 · see citing works
FTD and ALS: A Tale of Two Diseases
Ferrari, R., Kapogiannis, D., Huey, E. D., & Momeni, P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795563700 · Cited by 270 · see citing works
LEVENSON, R. W., Sturm, V. E., & Haase, C. M. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153653 · Cited by 193 · see citing works
Nisbet, R. M., Van der Jeugd, A., Leinenga, G., Evans, H. T., Janowicz, P. W., & Götz, J. (2017) · Brain · doi:10.1093/brain/awx052 · Cited by 187 · see citing works
Genomic variants, genes, and pathways of Alzheimer's disease: An overview
Naj, A. C., & Schellenberg, G. D. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32499 · Cited by 178 · see citing works
Dementia of the Alzheimer Type
Jalbert, J. J., Daiello, L. A., & Lapane, K. L. (2008) · Epidemiologic Reviews · doi:10.1093/epirev/mxn008 · Cited by 174 · see citing works
The translational neural circuitry of anxiety
Robinson, O. J., Pike, A. C., Cornwell, B., & Grillon, C. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321400 · Cited by 158 · see citing works
Mendez, M. F., Lauterbach, E. C., & Sampson, S. M. (2008) · Journal of Neuropsychiatry · doi:10.1176/jnp.2008.20.2.130 · Cited by 144 · see citing works
The Relationship Between Anxiety and Alzheimer’s Disease
Mendez, M. F. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210294 · Cited by 142 · see citing works
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes
Sýkora, P., Misiak, M., Wang, Y., Ghosh, S., Leandro, G. D. S., Liu, D., Tian, J. Y., Baptiste, B. A., Cong, W., Brenerman, B. M., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1356 · Cited by 136 · see citing works
The effects of oxytocin on social cognition and behaviour in frontotemporal dementia
Jesso, S., Morlog, D., Ross, S., Pell, M. D., Pasternak, S., Mitchell, D. G. V., KERTESZ, A. E., & Finger, E. C. (2011) · Brain · doi:10.1093/brain/awr171 · Cited by 129 · see citing works
Cognitive dysfunction and the neurobiology of ageing in cats
Gunn-Moore, D. A., Moffat, K., Christie, L., & Head, E. (2007) · Journal of Small Animal Practice · doi:10.1111/j.1748-5827.2007.00386.x · Cited by 120 · see citing works
Manwell, L. A., Tadros, M., Ciccarelli, T. M., & Eikelboom, R. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2101028 · Cited by 122 · see citing works
Fast, R., Schütt, T., Toft, N., Møller, A., & Berendt, M. (2013) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12109 · Cited by 117 · see citing works
Symptoms of Anxiety and Depression in the Course of Cognitive Decline
Bierman, E. J. M., Comijs, H. C., Jonker, C., & Beekman, A. T. F. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107083 · Cited by 110 · see citing works
Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A. E., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 105 · see citing works
Anxiety symptoms in mild cognitive impairment
Rozzini, L., Chilovi, B. V., Psy, M. P., Conti, M. Z., Rozzini, R., Trabucchi, M., & Padovani, A. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2106 · Cited by 106 · see citing works
Stanley, M. A., Calleo, J., Amspoker, A. B., WILSON, N. L., Snow, A. L., Kraus-Schuman, C. A., Paukert, A. L., Petersen, N. J., Brenes, G. A., Schulz, P. E., et al. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.007 · Cited by 104 · see citing works
The Construct of Generalized Anxiety Disorder in Alzheimer Disease
STARKSTEIN, S. E., Jorge, R. E., Petracca, G., & Robinson, R. G. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000229664.11306.b9 · Cited by 103 · see citing works
Peaceful mind: an open trial of cognitive-behavioral therapy for anxiety in persons with dementia
Paukert, A. L., Calleo, J., Kraus-Schuman, C. A., Snow, L., WILSON, N. L., Petersen, N. J., Kunik, M. E., & Stanley, M. A. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210000694 · Cited by 98 · see citing works
D’Onofrio, G., Sancarlo, D., Panza, F., Copetti, M., Cascavilla, L., Paris, F., Seripa, D., Matera, M. G., Solfrizzi, V., Pellegrini, F., et al. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322582 · Cited by 99 · see citing works
Rosenmann, H., Grigoriadis, N., Eldar-Levy, H., Avital, A., Rozenstein‐Tsalkovich, L., Touloumi, O., Behar, L., Ben‐Hur, T., Avraham, Y., Berry, E., et al. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.03.007 · Cited by 93 · see citing works
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Cognitive–behavioural therapy for anxiety in dementia: pilot randomised controlled trial
Spector, A. E., Charlesworth, G. M., King, M., Lattimer, M., Sadek, S. A., Marston, L., Rehill, A., Hoe, J., Qazi, A., Knapp, M. R. J., et al. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.140087 · Cited by 91 · see citing works
Functional neuroimaging and presenting psychiatric features in frontotemporal dementia
Mendez, M. F. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.072496 · Cited by 91 · see citing works
Sharma, S., Verma, S., Kapoor, M., Saini, A., & Nehru, B. (2016) · Neurological Research · doi:10.1080/01616412.2016.1209337 · Cited by 89 · see citing works
Phenomenology of Depression in Alzheimer’s Disease
Novais, F., & Starkstein, S. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-148004 · Cited by 85 · see citing works
Schütt, T., Toft, N., & Berendt, M. (2015) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13633 · Cited by 86 · see citing works
Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease
Berlow, Y. A., Wells, W. M., Ellison, J. M., Sung, Y. H., Renshaw, P. F., & Harper, D. G. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2418 · Cited by 82 · see citing works
Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology
Koss, D. J., Robinson, L., Drever, B. D., Plucińska, K., Stoppelkamp, S., Veselcic, P., Riedel, G., & Platt, B. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.002 · Cited by 76 · see citing works
Esmaeili, M. H., Bahari, B., & Salari, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.01.001 · Cited by 81 · see citing works
Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice
Siegel, J. A., Haley, G. E., & Raber, J. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.002 · Cited by 79 · see citing works
Cognitive-Behavioral Treatment for Anxiety in Patients With Dementia: Two Case Studies
Kraus, C. A., Seignourel, P. J., Balasubramanyam, V., Snow, A. L., WILSON, N. L., Kunik, M. E., Schulz, P. E., & Stanley, M. A. (2008) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000320120.68928.e5 · Cited by 68 · see citing works
The effect of anxiety and depression on decline of memory function in Alzheimer's disease
Bierman, E. J. M., Comijs, H. C., Jonker, C., Scheltens, P., & Beekman, A. T. F. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209990512 · Cited by 67 · see citing works
Liang, J., Lindemeyer, A. K., Shen, Y., López-Valdés, H. E., Martínez‐Coria, H., Shao, X. M., & Olsen, R. W. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1304-4 · Cited by 66 · see citing works
Panza, F., Frisardi, V., Seripa, D., D'Onofrio, G., Santamato, A., Masullo, C., Logroscino, G., Solfrizzi, V., & Pilotto, A. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.06.005 · Cited by 70 · see citing works
Differences in Anxiety Among Patients With Early- Versus Late-Onset Alzheimer’s Disease
Kaiser, N. C., Liang, L.-J. F., Melrose, R. J., Wilkins, S. S., Sultzer, D. L., & Mendez, M. F. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12100240 · Cited by 66 · see citing works
Kwak, Y. T., Yang, Y., & Koo, M. (2017) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2017.16.2.33 · Cited by 64 · see citing works
Shin, J., Gangadharan, G., Kim, S.-W., Kim, D., Lee, S. K., Kim, Y. S., Watanabe, M., & Shin, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3126-09.2009 · Cited by 64 · see citing works
Palmer, K., Lupo, F., Perri, R., Salamone, G., Fadda, L., Caltagirone, C., Musicco, M., & Cravello, L. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101836 · Cited by 61 · see citing works
Ross, J. A., Gliebus, G. P., & Bockstaele, E. J. V. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.004 · Cited by 62 · see citing works
Amani, M., Zolghadrnasab, M., & Salari, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.01.005 · Cited by 60 · see citing works
Collins, J., Henley, S. M. D., & Suárez-González, A. (2020) · International Psychogeriatrics · doi:10.1017/s1041610220001118 · Cited by 44 · see citing works
Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease.
Hashimoto, H., Monserratt, L., Nguyen, P., Feil, D., Harwood, D., Mandelkern, M., & Sultzer, D. (2006) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.2006.18.4.521 · Cited by 47 · see citing works
Bashiri, H., Enayati, M., Bashiri, A., & Salari, A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113003 · Cited by 57 · see citing works
Role of Apolipoprotein E in Anxiety
Raber, J. (2007) · Neural Plasticity · doi:10.1155/2007/91236 · Cited by 57 · see citing works
The Evaluation of a Compassion-Focused Therapy Group for Couples Experiencing a Dementia Diagnosis
Collins, R., Gilligan, L., & Poz, R. (2017) · Clinical Gerontologist · doi:10.1080/07317115.2017.1397830 · Cited by 56 · see citing works
APC/C Cdh1 -Rock2 pathway controls dendritic integrity and memory
Bobo-Jiménez, V., Delgado‐Esteban, M., Angibaud, J., Sánchez‐Morán, I., de la Fuente, A., Yajeya, J., Nägerl, U. V., Castillo, J., Bolaños, J. P., & Almeida, Á. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616024114 · Cited by 54 · see citing works
Breitve, M. H., Hynninen, M. J., Brønnick, K., Chwiszczuk, L. J., Auestad, B., Aarsland, D., & Rongve, A. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0171-4 · Cited by 51 · see citing works
Petrásek, T., Vojtěchová, I., Lobellová, V., Popelíková, A., Janikova, M., Brožka, H., Houdek, P., Sládek, M., Sumová, A., Krištofiková, Z., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00250 · Cited by 51 · see citing works
Alhusaini, M., Eissa, N., Saad, A. K., Beiram, R., & Sadek, B. S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.861094 · Cited by 49 · see citing works
Wojtunik‐Kulesza, K. A., Rudkowska, M., Kasprzak‐Drozd, K., Oniszczuk, A., & Borowicz, K. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147366 · Cited by 50 · see citing works
The frequency and correlates of anxiety in patients with first-time diagnosed mild dementia
Hynninen, M., Breitve, M., Rongve, A., Aarsland, D., & Nordhus, I. (2012) · International Psychogeriatrics · doi:10.1017/s1041610212001020 · Cited by 45 · see citing works
Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease
Gumus, M., Multani, N., Mack, M. L., Tartaglia, M. C., & Initiative, A. D. N. (2021) · GeroScience · doi:10.1007/s11357-020-00304-y · Cited by 45 · see citing works
User, carer and staff perspectives on anxiety in dementia: A qualitative study
Qazi, A., Spector, A. E., & Orrell, M. W. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.015 · Cited by 43 · see citing works
Specificity of Symptoms of Depression in Alzheimer Disease: A Longitudinal Analysis
Hasche, L. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000209395.08092.d9 · Cited by 43 · see citing works
Chwiszczuk, L. J., Breitve, M. H., Hynninen, M. J., Gjerstad, M. D., Aarsland, D., & Rongve, A. (2015) · Neurodegenerative Diseases · doi:10.1159/000439252 · Cited by 41 · see citing works
Gibbons, L. E., Teri, L. L., Logsdon, R. G., & McCurry, S. M. (2006) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988706292758 · Cited by 41 · see citing works
DMSO modulates CNS function in a preclinical Alzheimer's disease model
Penazzi, L., Lorengel, J., Sündermann, F., Golovyashkina, N., Marre, S., Mathis, C., Lewejohann, L., Brandt, R., & Bakota, L. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.020 · Cited by 38 · see citing works
Diagnosis and Management of Patients Presenting with Behavior Problems
Seibert, L. M., & Landsberg, G. M. (2008) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2008.04.001 · Cited by 37 · see citing works
Li, H., Zhao, J., Lai, L., Xia, Y., Wan, C., Wei, S., Liang, J., Chen, Y., & Xu, N. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.05.013 · Cited by 34 · see citing works
The neural basis of neuropsychiatric symptoms in Alzheimer’s disease
Zhang, N. K., Zhang, S. K., Zhang, L. I., Tao, H. W., & Zhang, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1487875 · Cited by 35 · see citing works
Specificity of Symptoms of Depression in Alzheimer Disease: A Longitudinal Analysis
STARKSTEIN, S. E., Mizrahi, R., & Garau, L. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200509000-00009 · Cited by 33 · see citing works
Starr, J. M., & Lonie, J. A. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000108632 · Cited by 32 · see citing works
Correlation between both Morphologic and Functional Changes and Anxiety in Alzheimer's Disease
Tagai, K., Nagata, T., Shinagawa, S., Nemoto, K., Inamura, K., Tsuno, N., & Nakayama, K. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000358822 · Cited by 31 · see citing works
Do Benzodiazepines Cause Alzheimer’s Disease?
Salzman, C. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20040375 · Cited by 31 · see citing works
Neural basis of motivational approach and withdrawal behaviors in neurodegenerative disease
Shinagawa, S., Adhimoolam, B., Sturm, V. E., Shany‐Ur, T., Ross, P. T., Zackey, D. D., Poorzand, P., Grossman, S. N., Miller, B. L., & Rankin, K. P. (2015) · Brain and Behavior · doi:10.1002/brb3.350 · Cited by 30 · see citing works
Tascone, L. D. S., & Bottino, C. M. D. C. (2013) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642013dn70300002 · Cited by 30 · see citing works
Benefits of Chair Yoga for Persons With Mild to Severe Alzheimer's Disease
Litchke, L. G., Hodges, J. S., & Reardon, R. F. (2012) · Activities Adaptation & Aging · doi:10.1080/01924788.2012.729185 · Cited by 30 · see citing works
Spector, A. E., Orrell, M. W., Lattimer, M., Hoe, J., King, M., Harwood, K. E., Qazi, A., & Charlesworth, G. M. (2012) · Trials · doi:10.1186/1745-6215-13-197 · Cited by 30 · see citing works
Psychometric properties of a structured interview guide for the rating for anxiety in dementia
Snow, A. L., Huddleston, C., Robinson, C. M., Kunik, M. E., Amspoker, A. B., WILSON, N. L., Calleo, J., Paukert, A. L., Kraus-Schuman, C. A., Petersen, N. J., et al. (2012) · Aging & Mental Health · doi:10.1080/13607863.2011.644518 · Cited by 29 · see citing works
Sharma, S., Sharma, N., Saini, A., & Nehru, B. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9975-2 · Cited by 29 · see citing works
Depression in Frontotemporal Dementia
Blass, D. M., & Rabins, P. V. (2009) · Psychosomatics · doi:10.1176/appi.psy.50.3.239 · Cited by 28 · see citing works
Benzodiazepine Use and Risk for Alzheimer Disease
Salzman, C., & Shader, R. I. (2014) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000247 · Cited by 28 · see citing works
Fostering the Resilience of People With Dementia: A Narrative Literature Review
Whelan, S., Teahan, Á., & Casey, D. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00045 · Cited by 28 · see citing works
Opdebeeck, C., Nelis, S. M., Quinn, C., & Clare, L. (2014) · Aging & Mental Health · doi:10.1080/13607863.2014.962005 · Cited by 28 · see citing works
Clinicians’ experiences of anxiety in patients with dementia
Goyal, A. R., Engedal, K., & Eriksen, S. (2016) · Dementia · doi:10.1177/1471301216659770 · Cited by 26 · see citing works
Geriatric Anxiety Inventory: Factor Structure and Associations with Cognitive Status
Diefenbach, G. J., Bragdon, L. B., & Blank, K. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.04.014 · Cited by 25 · see citing works
Kamel, A. S. E. D., Wahid, A. M., Abdelkader, N. F., & Ibrahim, W. W. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121002 · Cited by 23 · see citing works
Wang, Y., Chi, I., Zhan, Y., Chen, W., & Li, T. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.709860 · Cited by 22 · see citing works
Watanabe, S., Omran, A. J. A., Shao, A. S., Chen, X., Zhang, Z., Zhang, J., Davies, D. L., Shao, X. M., Watanabe, J., & Liang, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-09814-5 · Cited by 21 · see citing works
Panza, F., Seripa, D., D'Onofrio, G., Frisardi, V., Solfrizzi, V., Mecocci, P., & Pilotto, A. (2011) · International Journal of Alzheimer's Disease · doi:10.4061/2011/721457 · Cited by 20 · see citing works
Degenerative dementias: Alterations of emotions and mood disorders
Mendez, M. F. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-822290-4.00012-8 · Cited by 19 · see citing works
Mushtaq, R., Pinto, C., Tarfarosh, S. F. A., Hussain, A., Shoib, S., Shah, T., Shah, S., Manzoor, M., Bhat, M., & Arif, T. (2016) · Cureus · doi:10.7759/cureus.625 · Cited by 20 · see citing works
A Case of Late-Onset Obsessive Compulsive Disorder Developing Frontotemporal Lobar Degeneration
Nakaaki, S., Murata, Y., Shinagawa, Y., Hongo, J., Furukawa, T. A., Sato, J., & Tatsumi, H. (2007) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.19.4.487 · Cited by 19 · see citing works
Cognitive-behavioral treatment for depressed patients with Alzheimer’s disease. An open trial
García‐Alberca, J. M. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.02.008 · Cited by 19 · see citing works
Liu, Y., Cao, L., Zhang, X., Liang, Y., Xu, Y., & Zhu, C. (2019) · Neural Plasticity · doi:10.1155/2019/4168472 · Cited by 18 · see citing works
Fan, C.-H., Lin, C.-W., Huang, H.-J., Lee‐Chen, G., Sun, Y., Lin, W., Chen, C., Chang, K., Su, M., & Hsieh‐Li, H. M. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05602-z · Cited by 17 · see citing works
Managing anxiety associated with neurodegenerative disorders
Gomoll, B. P., & Kumar, A. A. (2014) · F1000Prime Reports · doi:10.12703/p7-05 · Cited by 17 · see citing works
Paukert, A. L., Kraus-Schuman, C. A., WILSON, N. L., Snow, A. L., Calleo, J., Kunik, M. E., & Stanley, M. A. (2013) · Behavior Modification · doi:10.1177/0145445513477420 · Cited by 17 · see citing works
Anxiety and the aging brain: Stressed out over p53?
Scrable, H. J., Burns‐Cusato, M., & Medrano, S. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.09.007 · Cited by 17 · see citing works
Developing dual functional allosteric modulators of GABAA receptors
Liu, X. F., Chang, H., Schmiesing, R. J., Wesolowski, S. S., Knappenberger, K. S., Arriza, J. L., & Chapdelaine, M. J. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.09.058 · Cited by 16 · see citing works
Sex and gender differences in dementia
Salwierz, P., Davenport, C., Sumra, V., Iulita, M. F., Ferretti, M. T., & Tartaglia, M. C. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.07.002 · Cited by 15 · see citing works
Meng, F., Zhao, J., Fang, H., & Liu, Y.-J. (2015) · Stress · doi:10.3109/10253890.2015.1040986 · Cited by 15 · see citing works
Taipa, R. J. F., Sousa, A. L., Pires, M. M., & Sousa, N. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160121 · Cited by 14 · see citing works
Cai, W., Initiative, A. D. N., Tian, Y., Ma, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210020 · Cited by 14 · see citing works
Chou, W.-Y., Waszynski, C. M., Kessler, J., Chiang, Y.-C., & Clarkson, P. J. (2016) · Geriatric Nursing · doi:10.1016/j.gerinurse.2016.02.013 · Cited by 14 · see citing works
- Authors
- Porter, V. R., Buxton, W. G., Fairbanks, L. A., Strickland, T., O'Connor, S. M., Rosenberg-Thompson, S., & Cummings, J. L.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2003-05
- Volume
- 15
- Issue
- 2
- Pages
- 180-186
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W1972048937
- Cited by
- 182
- References
- 28
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 15 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 7 · 2014: 12 · 2013: 11 · 2012: 9
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG016570, AG 16570)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- anxiety, Alzheimer's disease, frontotemporal dementia, vascular dementia, dementia, neuropsychiatric symptoms, Neuropsychiatric Inventory, cognitive impairment severity, age of onset, functional disability, prevalence
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Analysis of Variance, Anxiety, Cross-Sectional Studies, Dementia, Educational Status, Female, Frontal Lobe, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Sex Factors, Temporal Lobe, Test Anxiety Scale, Dementia, Vascular, Reproducibility of Results, Age of Onset
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