Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP

Cited by (244)

Items 201–244 of 244

1. Genetic mapping of APP and amyloid-β biology modulation by trisomy 21
   Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou, Gloria Lau, Suzanna Noy, Karen Cleverley, Takashi Saito, Takaomi C. Saido, Eugene Y. Yu et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
2. Partial trisomy 21 with or without highly restricted-Down syndrome critical region (HR- DSCR). Report of two new cases and reanalysis of the genotype-phenotype association
   Maria Chiara Pelleri, Chiara Locatelli, Teresa Mattina, María Clara Bonaglia, Francesca Piazza, Pamela Magini, Francesca Antonaros, Giuseppe Ramacieri, Beatrice Vione, Lorenza Vitale et al. · 2022 · Research Square
3. Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease – Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
   Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris J. van Dalen, Martijn Verdoes, Elizabeth Fisher, Frances K. Wiseman · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
4. Amyloid beta: from pre-analytical factors to disease mechanisms
   Jamie Toombs · 2019 · UCL Discovery (University College London)
5. Detection of Plasma Level of Amyloid Protein Precursor in Children and Adolescent with Down Syndrome
   M.Sc. MOHAMMED A. ROWISHA FATMA AL ZAHRAA N.M. SHERAI, Maaly M. Mabrouk · 2019 · The Medical Journal of Cairo University/The Medical Journal of Cairo University
6. Lysosomal Dysfunction in Down Syndrome and Alzheimer Mouse Models is Caused by Selective V-Atpase Inhibition by Tyr 682 Phosphorylated APP βCTF
   Eunju Im, Ying Jiang, Philip H. Stavrides, Sandipkumar Darji, Hediye Erdjument‐Bromage, Neubert A. Thomas, Matteo Bordi, Jun Yong Choi, Ju‐Hyun Lee, Ralph A. Nixon · 2022 · SSRN Electronic Journal
7. Alzheimer disease and neuroinflammation in Down syndrome
   Bani Bandana Ganguly · 2022 · Elsevier eBooks
8. Outcomes of use of the quality outcome measure for individuals with dementia (QOMID) with people with Down’s syndrome and dementia
   Aoife Ryan, Karen Dodd · 2023 · Advances in Mental Health and Intellectual Disabilities
9. Clinical efficacy and controversies of aducanumab
   Qingyue Gao · 2023 · International Conference on Modern Medicine and Global Health (ICMMGH)
10. Cognitive and molecular characterization of the Ts66Yah murine model of Down syndrome: deepening on hippocampal changes associated with genotype and aging
    Chiara Lanzillotta, Monika Rataj-Baniowska, Francesca Prestia, Chiara Sette, Valérie Nalesso, Marzia Perluigi A, Eugenio Barone, Arnaud Duchon, Antonella Tramutola, Yann Hérault et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
11. Avaliação de microinfartos corticais em pacientes com síndrome de Down
    Mateus Rozalem Aranha · 2023
12. Exploring the complex nexus of Alzheimer’s disease in down syndrome
    Yuxin Li · 2024 · Theoretical and Natural Science
13. Aging and dementia in Down syndrome
    Sheliza Ali, Kathryn L. Van Pelt, Elizabeth Head, Jordan P. Harp, Amanda C. Glueck, Frederick A. Schmitt · 2024 · Elsevier eBooks
14. A novel generation of potent gamma-secretase modulators: Combat Alzheimer’s disease and Down syndrome–associated Alzheimer’s disease
    Xu‐Qiao Chen · 2024 · Neural Regeneration Research
15. Copy number variations of proteins associated with neurodegenerative diseases and rare neurological disorders
    Zhangzhong Yang, Peng Lei · 2024 · Scientia Sinica Vitae
16. Human Models of Down Syndrome
    Megan Jandy, Hao Hu, Yan Liu, Anita Bhattacharyya · 2025 · Springer eBooks
17. Using Drosophila to Study the Mechanisms That Underlie Down Syndrome
    Bing Ye · 2025 · Springer eBooks
18. Familial Alzheimer’s disease and Down syndrome
    Rudy J. Castellani · 2025 · Elsevier eBooks
19. The amyloid cascade hypothesis
    Rudy J. Castellani · 2025 · Elsevier eBooks
20. DSCAM preserves neuronal order during radial migration by antagonizing N-Cadherin adhesion and UNC5c repulsion
    Tao Yang, Ty Hergenreder, Macy W. Veling, Wei-Chih Chang, Elaine J. Cui, Yu Wang, Peter G. Fuerst, Roman J. Giger, Xiaofeng Zhao · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
21. Down Syndrome: Progress in Defining Pathogenesis and Treatments for Neurodevelopmental Deficits and Alzheimer’s Disease
    Renata Bartesaghi, Xu‐Qiao Chen, Aaron D. Johnstone, Utpal Das, William Cary Mobley · 2025 · Springer eBooks
22. Investigating the eye in Down syndrome as a window to Alzheimer’s disease: the REVEAL protocol – a clinical cross-sectional study
    Aoife Mary Louise Hunter, Sarah D. Atkinson, Elaine K. Murray, Kathryn J. Saunders, Tünde Pető, Lajos Csincsik, Jamie Mitchell, Henrik Zetterberg, André Strydom, Julie‐Anne Little et al. · 2025 · BMJ Open
23. Neuropsychological profile of an adult with Down syndrome-Klinefelter syndrome
    Alyssa W Sullivan, Margaret B. Pulsifer · 2025 · Applied Neuropsychology Adult
24. Additional file 2 of Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase
    Mengel, David, Liu, Wen, Glynn, Robert J., Selkoe, Dennis J., André Strydom, Lai, Florence, Herminia Diana Rosas, Amy Torres, Vasiliki Patsiogiannis, Brian G. Skotko et al. · 2020 · Figshare
25. Additional file 2 of Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
    Alison M. Maxwell, Peng Yuan, Brianna M. Rivera, Schaaf, Wilder, Mihovil Mladinov, Prasher, Vee P., Andrew Robinson, William F. DeGrado, Carlo Condello · 2021 · Figshare
26. Additional file 1 of Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
    Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Luo, Dinghao, van Dalen, Floris, Martijn Verdoes, Elizabeth Fisher, Frances K. Wiseman · 2023 · Figshare
27. Additional file 1 of Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase
    Mengel, David, Liu, Wen, Glynn, Robert J., Selkoe, Dennis J., André Strydom, Lai, Florence, Herminia Diana Rosas, Amy Torres, Vasiliki Patsiogiannis, Brian G. Skotko et al. · 2020 · Figshare
28. Additional file 1 of Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
    Alison M. Maxwell, Peng Yuan, Brianna M. Rivera, Schaaf, Wilder, Mihovil Mladinov, Prasher, Vee P., Andrew Robinson, William F. DeGrado, Carlo Condello · 2021 · Figshare
29. Additional file 1 of Partial trisomy 21 with or without highly restricted Down syndrome critical region (HR-DSCR): report of two new cases and reanalysis of the genotype–phenotype association
    Maria Chiara Pelleri, Locatelli, Chiara, Teresa Mattina, Bonaglia, Maria Clara, Francesca Piazza, Pamela Magini, Francesca Antonaros, Giuseppe Ramacieri, Beatrice Vione, Lorenza Vitale et al. · 2024 · Figshare
30. Additional file 1 of Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport
    Chen, Xu-Qiao, Utpal Das, Gooho Park, William Cary Mobley · 2021 · Figshare
31. Additional file 2 of Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
    Ujjayini Ghosh, Tse, Eric, Hyunjun Yang, Marie Shi, Caro, Christoffer D., Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello · 2024 · Figshare
32. Additional file 1 of Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
    Ujjayini Ghosh, Tse, Eric, Hyunjun Yang, Marie Shi, Caro, Christoffer D., Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello · 2024 · Figshare
33. Probable cerebral amyloid angiopathy - related inflammation in a 32-year-old woman with down syndrome
    Thales Pardini Fagundes, Gustavo Maximiano Alves, Mateus Gustavo Favaro, Joyce Yuri Silvestre Yamamoto, Lucas Ravagnani Silva, Lucas Giansante Abud, Jorge Alberto Martins Pentiado · 2026 · Neurogenetics
34. Decoding Alzheimer's disease through down syndrome: insights from a genetically defined population
    Jason K Russell, Zinayida Schlachetzki, Michael S. Rafii · 2026 · Current Opinion in Neurology
35. Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan
    Jesse R. Pascual, Isabel Rivera, Halyma Nguyen, Phong T. Ngo, Alan Hoang, Elizabeth J. Andrews, Jeremy P. Rouanet, Sierra T. Wright, Lorena Sordo, Julia K. Kofler et al. · 2026 · Acta Neuropathologica
36. Inhaled General Anesthetics in Alzheimer’s Disease Progression: Divergent Effects, Underlying Mechanisms, and Future Perspectives
    Luoman Yang, Ge Song, Emily Parker, Luodan Yang · 2026 · Molecular Neurobiology
37. Huntingtin functions in the regulation of axonal transport : consequences on neuronal network homeostasis and behavior, in health and disease
    Hélène Vitet · 2020 · theses.fr (ABES)
38. Unraveling the physiopathological actions of the newly discovered Aη peptides in the brain
    Maria Mensch · 2020 · theses.fr (ABES)
39. Recherches de biomarqueurs impliqués dans la maladie d’Alzheimer et associés à la protéine DYRK1A dans le syndrome de Down pour valider des traitements potentiels
    Yuchen Gu · 2020 · theses.fr (ABES)
40. Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome
    Victoria Fleming, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Mark E. Mapstone, Melissa E. Petersen, Sharon J. Krinsky‐McHale, Christy L. Hom, Davneet Singh Minhas, Weiquan Luo et al. · 2026 · Obesity
41. Multiomics and proteomic insights into Alzheimer’s disease biology in Down syndrome
    Mitchell Martá-Ariza, T R Wisniewski · 2026 · Expert Review of Neurotherapeutics
42. DNA- and aptamer-based biosensors for Alzheimer's disease biomarkers toward clinical translation
    Yasamin Pahlavan, Mehran Nozari-Asbemarz, Mojtaba Amani, Elnaz Hasani, Mehrshad Aliakbari, Seyed Hossein Khaleghinejad, Fereshteh Pahlavan, Anita Emami, Hamideh Imanzadeh · 2026 · Talanta
43. Periodontitis and Alzheimer's disease, common pathways in down syndrome
    Fabio Arriola‐Pacheco, Alicia Leonor Pinzón-Te, Rodrigo Serrano-Piña, Bertha Arelly Carrillo-Ávila, Jaime Díaz‐Zúñiga, Samanta Melgar‐Rodríguez, Víctor Manuel Martínez-Aguilar · 2026 · Frontiers in Dental Medicine
44. Chromosome 21 gene dosage and Alzheimer's disease in Down syndrome: DYRK1A mechanism and its translation to blood-based biomarkers
    Ainaz Shateri · 2026 · Journal of Alzheimer s Disease