Lott, Ira T.

Retinoic acid embryopathy

Lammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine

Pregnancy and Medication ImpactPharmacological Effects and Toxicity Studies

Cited by 1,942

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

Lott, I. T., & Dierssen, M. (2010) · The Lancet Neurology

Down syndrome and intellectual disability researchDementia and Cognitive Impairment Research

Cited by 484

The genetic architecture of down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

Korbel, J. O., Tirosh-Wagner, T., Urban, A. E., Chen, X.-N., Kasowski, M., Dai, L., Grubert, F., Erdman, C., Gao, M. C., Lange, K., et al. (2009) · Proceedings of the National Academy of Sciences

Down syndrome and intellectual disability researchGenomic variations and chromosomal abnormalities

Cited by 399

Dementia in Down syndrome: unique insights for Alzheimer disease research

Lott, I. T., & Head, E. (2019) · Nature Reviews Neurology

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 383

Down syndrome and Alzheimer's disease: common pathways, common goals

Hartley, D., Blumenthal, T., Carrillo, M., DiPaolo, G., Esralew, L., Gardiner, K., Granholm, A.-C., Iqbal, K., Krams, M., Lemere, C., et al. (2015) · Alzheimer's & Dementia

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 290

Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP

Doran, E., Keator, D., Head, E., Phelan, M. J., Kim, R., Totoiu, M., Barrio, J. R., Small, G. W., Potkin, S. G., & Lott, I. T. (2017) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 244

Neurological phenotypes for Down syndrome across the life span

Lott, I. T. (2012) · Progress in Brain Research

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 225

Alzheimer disease and Down syndrome: factors in pathogenesis

Lott, I. T., & Head, E. (2005) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 212

Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down’s syndrome

Kesslak, J. P., Nagata, S. F., Lott, I., & Nalcioglu, O. (1994) · Neurology

Down syndrome and intellectual disability researchDementia and Cognitive Impairment Research

Cited by 145

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

Sanchez-Mut, J. V., Aso, E., Panayotis, N., Lott, I., Dierssen, M., Rabano, A., Urdinguio, R. G., Fernandez, A. F., Astudillo, A., Martin-Subero, J. I., et al. (2013) · Brain

Epigenetics and DNA MethylationAlzheimer's disease research and treatments

Cited by 144

Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

Lott, I. T., Doran, E., Nguyen, V. Q., Tournay, A., Head, E., & Gillen, D. L. (2011) · American Journal of Medical Genetics Part A

Down syndrome and intellectual disability researchDementia and Cognitive Impairment Research

Cited by 136

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

Hamlett, E. D., Goetzl, E. J., Ledreux, A., Vasilevko, V., Boger, H. A., LaRosa, A., Clark, D., Carroll, S. L., Carmona‐Iragui, M., Fortea, J., et al. (2017) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 129

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease

Miyoshi, E., Morabito, S., Henningfield, C. M., Das, S., Rahimzadeh, N., Shabestari, S. K., Michael, N., Emerson, N., Reese, F., Shi, Z., et al. (2024) · Nature Genetics

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 115

Cerebrovascular pathology in Down syndrome and Alzheimer disease

Head, E., Phelan, M. J., Doran, E., Kim, R. C., Poon, W. W., Schmitt, F. A., & Lott, I. T. (2017) · Acta Neuropathologica Communications

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 105

Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome

Head, E., Garzon-Rodriguez, W., Johnson, J. K., Lott, I. T., Cotman, C. W., & Glabe, C. (2001) · Neurobiology of Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 75

Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome

Martini, A. C., Helman, A. M., McCarty, K. L., Lott, I. T., Doran, E., Schmitt, F. A., & Head, E. (2020) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 66

Synaptophysin and Synaptojanin-1 in Down Syndrome are Differentially Affected by Alzheimer's Disease

Martin, S. B., Dowling, A. L. S., Lianekhammy, J., Lott, I. T., Doran, E., Murphy, M. P., Beckett, T. L., Schmitt, F. A., & Head, E. (2014) · Journal of Alzheimer's Disease

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 64

Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers

Janelidze, S., Christian, B. T., Price, J., Laymon, C., Schupf, N., Klunk, W. E., Lott, I., Silverman, W., Rosas, H. D., Zaman, S., et al. (2022) · JAMA Neurology

Dementia and Cognitive Impairment ResearchDown syndrome and intellectual disability research

Cited by 60

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Boerwinkle, A. H., Gordon, B. A., Wisch, J., Flores, S., Henson, R. L., Butt, O. H., McKay, N., Chen, C. D., Benzinger, T. L. S., Fagan, A. M., et al. (2023) · The Lancet Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 55

The Alzheimer's Biomarker Consortium–Down Syndrome (ABC‐DS): A 10‐year report

Handen, B. L., Mapstone, M., Hartley, S., Andrews, H., Christian, B., Lee, J. H., Tudorascu, D., Hom, C., Ances, B. M., Zaman, S., et al. (2025) · Alzheimer's & Dementia

Down syndrome and intellectual disability researchDementia and Cognitive Impairment Research

Cited by 29

The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome

Boerwinkle, A. H., Wisch, J. K., Handen, B. L., Head, E., Mapstone, M., Rafii, M. S., O'Bryant, S. E., Krinsky‐McHale, S. J., Lai, F., Rosas, H. D., et al. (2025) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 14