Cited by 216Obstructive Sleep Apnea ResearchDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease

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Andrade, Andreia G., Bubu, Omonigho M., Varga, Andrew W., Osorio, Ricardo S.·2018·Journal of Alzheimer's Disease

DOI 10.3233/jad-179936PMC PMC6542637

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Abstract

Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent conditions with growing impact on our aging society. While the causes of OSA are now better characterized, the mechanisms underlying AD are still largely unknown, challenging the development of effective treatments. Cognitive impairment, especially affecting attention and executive functions, is a recognized clinical consequence of OSA. A deeper contribution of OSA to AD pathogenesis is now gaining support from several lines of research. OSA is intrinsically associated with disruptions of sleep architecture, intermittent hypoxia and oxidative stress, intrathoracic and hemodynamic changes as well as cardiovascular comorbidities. All of these could increase the risk for AD, rendering OSA as a potential modifiable target for AD prevention. Evidence supporting the relevance of each of these mechanisms for AD risk, as well as a possible effect of AD in OSA expression, will be explored in this review.

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Authors: Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S.
Affiliations: NYU Langone Health (US)
University of South Florida (US)
Icahn School of Medicine at Mount Sinai (US)
Nathan Kline Institute for Psychiatric Research (US)
Corresponding author: Andrade, Andreia G.
Osorio, Ricardo S.
ORCID: Bubu, Omonigho M.
Varga, Andrew W.
Osorio, Ricardo S.
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2018-06-12
Volume: 64
Issue: s1
Pages: S255-S270
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-179936
PMC: PMC6542637
OpenAlex: W2804158148
Cited by: 216
References: 191
Citations by year: 2026: 18 · 2025: 29 · 2024: 38 · 2023: 43 · 2022: 32 · 2021: 29 · 2020: 19 · 2019: 5 · 2018: 1
FWCI: 1.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
Funders: National Institute on Aging (R01AG056682, R01AG022374, R21AG055002, R21AG049348, P30AG008051, R01AG056031, R21AG059179)
National Heart, Lung, and Blood Institute (R01HL118624)
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: obstructive sleep apnea, Alzheimer's disease
MeSH terms: Alzheimer Disease, Animals, Humans, Sleep Apnea, Obstructive

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