The DOI matches its Crossref record.
Lipid Peroxidation and Oxidative imbalance: Early functional events in Alzheimer's disease
Abstract
Alzheimer's disease (AD) is a growing public health problem worldwide. Clinically, AD is a progressive neurodegenerative disorder characterized by a global cognitive decline. Accumulating evidence indicates that reactive oxygen species-mediated reactions, particularly of neuronal lipids, are extensive in those AD brain areas directly involved in the disease processes. Traditional views claim that oxidative-mediated tissue injury in the AD brain is the result of neurodegeneration. In recent years, numerous investigations have pointed to the functional importance of oxidative imbalance as a crucial event in mediating AD pathogenesis. The availability of specific and sensitive markers to monitor in vivo oxidative stress, in combination with studies performed in living patients with clinical diagnosis of AD are helping us to elucidate these issues. The evidence we have accumulated so far clearly indicates that oxidative imbalance and subsequent oxidative stress are early events during the evolution of the disease, and secondary to specific mechanism(s) present in AD but not in other neurodegenerative diseases. These new concepts implicate that this phenomenon may play a more important role in AD pathogenesis than previously anticipated, and that any therapeutic intervention targeting oxidative stress should be initiated at the earliest possible stage of the disease.
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In the citing paper
“the brain contains the high levels of polyunsaturated fatty acids (PUFAs) in its membrane rich architecture”
In the citing paper
“lipid peroxidation could be a major feature of ferroptosis in AD”
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Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044
Hambright, W. S., Fonseca, R. S., Chen, L., Na, R., & Ran, Q. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.021 · Cited by 851
“Indeed, lipid peroxidation is believed to be an early event in AD pathogenesis [9].”
BackgroundOxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855
“[13] D.”
Park, M. W., Cha, H. W., Kim, J., Kim, J. H., Yang, H., Yoon, S., Boonpraman, N., Yi, S. S., Yoo, I. D., & Moon, J.-S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101947 · Cited by 683
“Since the brain contains the high levels of polyunsaturated fatty acids (PUFAs) in its membrane rich architecture, lipid peroxidation could be a major feature of ferroptosis in AD [53,54].”
BackgroundApoptosis and Oxidative Stress in Neurodegenerative Diseases
Radi, E., Formichi, P., Battisti, C., & Federico, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132738 · Cited by 641
Metadata
- Authors
- Praticò, D., & Sung, S.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Praticò, Domenico
- ORCID
- Praticò, Domenico
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2004-04-13
- Volume
- 6
- Issue
- 2
- Pages
- 171-175
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1889306845
- Cited by
- 229
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 11 · 2012: 15
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P01AG011542, AG 11542)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- Alzheimer's disease, lipid peroxidation
- MeSH terms
- Alzheimer Disease, Cognition Disorders, Frontal Lobe, Humans, Temporal Lobe, Time Factors, Lipid Peroxidation, Oxidative Stress, Isoprostanes
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