Cited by 230Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative Stress

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Lipid Peroxidation and Oxidative imbalance: Early functional events in Alzheimer's disease

Praticò, Domenico, Sung, Syun·2004·Journal of Alzheimer s Disease

DOI 10.3233/jad-2004-6209

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Abstract

Alzheimer's disease (AD) is a growing public health problem worldwide. Clinically, AD is a progressive neurodegenerative disorder characterized by a global cognitive decline. Accumulating evidence indicates that reactive oxygen species-mediated reactions, particularly of neuronal lipids, are extensive in those AD brain areas directly involved in the disease processes. Traditional views claim that oxidative-mediated tissue injury in the AD brain is the result of neurodegeneration. In recent years, numerous investigations have pointed to the functional importance of oxidative imbalance as a crucial event in mediating AD pathogenesis. The availability of specific and sensitive markers to monitor in vivo oxidative stress, in combination with studies performed in living patients with clinical diagnosis of AD are helping us to elucidate these issues. The evidence we have accumulated so far clearly indicates that oxidative imbalance and subsequent oxidative stress are early events during the evolution of the disease, and secondary to specific mechanism(s) present in AD but not in other neurodegenerative diseases. These new concepts implicate that this phenomenon may play a more important role in AD pathogenesis than previously anticipated, and that any therapeutic intervention targeting oxidative stress should be initiated at the earliest possible stage of the disease.

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Authors: Praticò, D., & Sung, S.
Affiliations: University of Pennsylvania (US)
Corresponding author: Praticò, Domenico
ORCID: Praticò, Domenico
Venue: Journal of Alzheimer s Disease
Publisher: SAGE Publications
Published: 2004-04-13
Volume: 6
Issue: 2
Pages: 171-175
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2004-6209
OpenAlex: W1889306845
Cited by: 229
References: 0
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 11 · 2012: 15
FWCI: 8.22
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (P01AG011542, AG 11542)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: Alzheimer's disease, lipid peroxidation
MeSH terms: Alzheimer Disease, Cognition Disorders, Frontal Lobe, Humans, Temporal Lobe, Time Factors, Lipid Peroxidation, Oxidative Stress, Isoprostanes

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Lipid Peroxidation and Oxidative imbalance: Early functional events in Alzheimer's disease

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