Cited by 723Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer’s disease: Link to brain reductions in acetylcholine

Rivera, Enrique J., Goldin, Alison, Fulmer, Noah, Tavares, Rose, Wands, Jack R., de la Monte, Suzanne M.·2005·Journal of Alzheimer s Disease

DOI 10.3233/jad-2005-8304

Open this paper in CoChat — free account

Abstract

Reduced glucose utilization and energy metabolism occur early in the course of Alzheimer's disease (AD) and correlate with impaired cognition. Glucose utilization and energy metabolism are regulated by insulin and insulin-like growth factor I (IGF-I), and correspondingly, studies have shown that cognitive impairment may be improved by glucose or insulin administration. Recently, we demonstrated significantly reduced levels of insulin and IGF-I polypeptide genes and their corresponding receptors in advanced AD relative to aged control brains. The abnormalities in gene expression were accompanied by impaired survival signaling downstream through PI3 kinase-Akt. The present work characterizes the abnormalities in insulin and IGF gene expression and receptor binding in brains with different Braak stage severities of AD. Realtime quantitative RT-PCR analysis of frontal lobe tissue demonstrated that increasing AD Braak Stage was associated with progressively reduced levels of mRNA corresponding to insulin, IGF-I, and IGF-II polypeptides and their receptors, tau, which is regulated by insulin and IGF-I, and the Hu D neuronal RNA binding protein. In contrast, progressively increased levels of amyloid beta protein precursor (AbetaPP), glial fibrillary acidic protein, and the IBA1/AIF1 microglial mRNA transcripts were detected with increasing AD Braak Stage. Impairments in growth factor and growth factor receptor expression and function were associated with increasing AD Braak stage dependent reductions in insulin, IGF-I, and IGF-II receptor binding, ATP levels, and choline acetyltransferase (ChAT) expression. Further studies demonstrated that: 1) ChAT expression increases with insulin or IGF-I stimulation; 2) ChAT is expressed in insulin and IGF-I receptor-positive cortical neurons; and 3) ChAT co-localization in insulin or IGF-I receptor-positive neurons is reduced in AD. Together, these data provide further evidence that AD represents a neuro-endocrine disorder that resembles a unique form of diabetes mellitus (? Type 3) and progresses with severity of neurodegeneration.

Integrity signals

Registry

Crossref · 10.3233/jad-2005-8304

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L., Dull, T. J., Gray, A., Coussens, L. M., Liao, Y.-C., Tsubokawa, M., et al. (1985) · Nature · doi:10.1038/313756a0 · Cited by 2,251
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
Burgering, B. M. T., & Coffer, P. J. (1995) · Nature · doi:10.1038/376599a0 · Cited by 2,076
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?
Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J. R., & Dedhar, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11211 · Cited by 1,102
Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt
Kulik, G., Klippel, A., & Weber, M. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1595 · Cited by 1,038
A Novel Geneiba1in the Major Histocompatibility Complex Class III Region Encoding an EF Hand Protein Expressed in a Monocytic Lineage
Imai, Y., Ibata, I., Ito, D., Ohsawa, K., & Kohsaka, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1112 · Cited by 872 · cited 1×
“Signiﬁcant P-values are indicated over the bar graphs. and ionized calcium-binding adaptor molecule 1 (IBA-1) to speciﬁcally detect neurons (Hu) [31–33], astrocytes (GFAP), or microglial cells (AIF1 and IBAI) [34, 35] (Table 2).”
Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation
Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B., & Selkoe, D. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32730 · Cited by 812

Flagged first, then by citations

Show all 71 references

Sorted by citations

Items 601–700 of 721

Is resveratrol a prospective therapeutic strategy in the co-association of glucose metabolism disorders and neurodegenerative diseases?
Ribeiro, R., dos Santos, A. C. S., Calazans, M., de Oliveira, A. C. P., & Vieira, L. B. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1972514 · Cited by 4
Insulin Resistance Alzheimer's Disease: Pathophysiology and Treatment
Watson, G. S., & Craft, S. (2007) · Progress in Neurotherapeutics and Neuropsychopharmacology · doi:10.1017/s1748232107000031 · Cited by 3
Targeting the non-neuronal cholinergic machinery: A novel approach to mitigate cardiac aging
Chakraborty, S., Tiwari, V., & Banerjee, S. K. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102782 · Cited by 2
Therapeutic potential of phytocannabinoids in depression and cognitive dysfunction: Evidence from preclinical models
Fonseca, C., Gouveia, F., Silva, S., Castanheira, S., Driouech, L., Matos, A. M., Barbosa, R. M., Camins, A., Falcão, A. C., Ettcheto, M., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119298 · Cited by 2
Cognitive Dysfunction and Diabetes
Jung, C., & Mok, J. (2022) · Journal of Korean Diabetes · doi:10.4093/jkd.2022.23.3.165 · Cited by 2
“그러므로 적은 인슐린 농도와 낮은 인슐린수용체의 민 감도는 아세틸콜린의 농도를 감소시킬 수 있어 알츠하이머병 에서 인지기능 저하의 원인 중 하나로 작용할 수 있다[28].”
Treatment of Diabetes Mellitus by Acupuncture: Dynamics of Blood Glucose Level and Its Mathematical Modelling
Šimat, M., Makek, M. J., & Mičetić, M. (2023) · Sci · doi:10.3390/sci5040038 · Cited by 2
Role of Central Insulin-Like Growth Factor-1 Receptor Signalling in Ageing and Endocrine Regulation
Moll, L., Zemva, J., & Schubert, M. (2011) · InTech eBooks · doi:10.5772/22924 · Cited by 1
“Additionally, the expression of the IGF-1R was reduced in AD brains compared to controls (Moloney et al. 2010; Rivera et al. 2005).”
Background
Genomic Linkage Between Alzheimer's Disease and Type 2 Diabetes
Nedjadi, T., Haque, A., Alam, Q., Gan, S. H., Chaudhary, A., Abuzenadah, A. M., Damanhouri, G. A., & Kamal, M. A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660140 · Cited by 2
“Thus, glucose imbalances lead to the progressive impairment of the brain’s capacity to utilize glucose and respond to insulin and insulin-like growth factors (IGF), which regulate neuronal survival, energy metabolism, and plasticity and are required for learning and memory [62, 63].”
Background
The Contribution of the Amyloid Hypothesis to the Understanding of Alzheimer's Disease: A Critical Overview
Morelli, L., Perry, G. L., & Tagliavini, F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/709613 · Cited by 2
“[22] N.”
BackgroundInfluential
POTENTIAL NON-GROWTH USES OF rhIGF-I.
Kim, R. J., & Grimberg, A. (2007) · PubMed · Cited by 2
«Ageingfeatures» analysis of IGF-1 and PGC-1 genes polymorphism
Владимировна, П. С., Glotov, O. S., & Баранов, В. С. (2009) · Ecological genetics · doi:10.17816/ecogen7112-18 · Cited by 2
The Principal Inferior Olivary Nucleus in Aging and Alzheimer's Disease
Lasn, H. (2006) · Figshare · Cited by 2
Type 2 Diabetes and Alzheimer's Disease: From Common Pathologies to Potential New Therapeutics
Levy, D. E. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100418 · Cited by 2
Large-scale proteome and metabolome analysis of CSF implicates altered glucose metabolism and succinylcarnitine in Alzheimer’s diseasePreprint
Panyard, D. J., McKetney, J., Deming, Y. K., Morrow, A. R., Ennis, G. E., Jonaitis, E. M., Hulle, C. A. V., Yang, C., Sung, Y. J., Ali, M., et al. (2021) · medRxiv · doi:10.1101/2021.09.02.21262642 · Cited by 2
Type 3 diabetes (T3D) and alzheimer’s disease (AD)
Shivananjappa, M. M. (2022) · Current Trends in Pharmacy and Pharmaceutical Chemistry · doi:10.18231/j.ctppc.2022.003 · Cited by 1
ARI EKMEĞİNİN ALZHEİMER SIÇAN MODELİNDE KARACİĞER 5HT2B ARACILI GLUKOZ DÜZENLEMESİ ÜZERİNE ETKİSİ
Afşar, E., Doğan, K., Kantar, D., & Acun, A. D. (2024) · Kocatepe tıp dergisi. · doi:10.18229/kocatepetip.1433727 · Cited by 1
Role of insulin-like growth factor-2 in Alzheimer’s disease induced memory impairment and underlying mechanisms
Chen, R., Lu, X., Xiao, A., & Ma, J. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1520253 · Cited by 4
Optimizing the structure of repurposed metformin can improve anti-cholinesterase and anti-amyloidogenic effects
Markowicz-Piasecka, M., Laitinen, T., & Huttunen, K. M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177886 · Cited by 1
Mechanisms of cognitive impairment in arterial hypertension
Kotlyarov, S. N. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i7.106597 · Cited by 1
Potential application of nanotechnology in Type-3 diabetes: Bridging insulin resistance and neurodegeneration
Ghosh, A., Sarkar, S., Mandal, D., Orasugh, J. T., Ray, S. S., & Chattopadhyay, D. (2025) · Nano Trends · doi:10.1016/j.nwnano.2025.100144 · Cited by 2
The role of IGF1 signaling in remote ischemic conditioning-mediated amelioration of Alzheimer's disease pathology and cerebral insulin resistance
Li, J., Sun, W., Guo, S., Bai, J., Yuan, T., Gao, F., Zhang, X., Ma, H., Ma, Y., An, J., et al. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115685 · Cited by 1
Dysregulated glucose metabolism in the visual cortex of human subjects with mild cognitive impairment and Alzheimer’s disease
Mjaaseth, U. N., Hsu, M.-F., Arballo, J., Haj, F. G., & Patel, V. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1710075 · Cited by 2
“Multiple studies demonstrate that AD patients exhibit elevated neuronal insulin resistance and reduced expression of the insulin receptor and insulin like-growth factor receptors required for insulin signaling (Rivera et al., 2005; Talbot et al., 2012; Steen et al., 2005).”
Molecular Aspects of Obesity and Insulin Resistance in Metabolic Syndrome and Neurological Disorders
Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_5 · Cited by 1
INVESTIGATION ON THE EXPRESSION OF IGF-I PROTEIN IN INSULIN-RESISTANT RAT BRAIN
Azita, P. T., Jalal, R., Shamila, D., Sepehri, H., & Adeli, K. (2010) · Cited by 1
The Role of Insulin Resistance in Age-Related Cognitive Decline and Dementia
Watson, G. S., & Craft, S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-850-8_18 · Cited by 1
Experimental approach to Alzheimer's disease
Šalković‐Petrišić, M., Hoyer, S., & Riederer, P. F. (2013) · Cited by 1
Intranasal applications in Alzheimer's treatment
Konaklı, M. İ. (2020) · Demiroglu Science University Florence Nightingale Journal of Medicine · doi:10.5606/fng.btd.2020.25038 · Cited by 1
“Patients with AD have reduced insulin receptor sensitivity in the brain.[21,22] Insulin has important functions in the CNS.”
Background
Experimental Approach to Alzheimer Disease
Salkovic-Petrisic, M., Hoyer, S., & Riederer, P. F. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_98 · Cited by 1
Role of Reactive Astrocytes in Alzheimer’s Disease
Sarkar, S., Guha, S., & Biswas, S. C. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_9 · Cited by 1
Aegle Marmelos (L.) Correa, A Potential Source for the Treatment of Diabetes Associated Alzheimer’s Disease: A Review
(2019) · Open Access Journal of Pharmaceutical Research · doi:10.23880/oajpr-16000186 · Cited by 1
“But a single dose of insulin injection reverted the effect of high fat diet and reduced the amount of brain soluble Aβ and enhanced memory [75].”
Insulin Resistance Syndrome and Alzheimer’s Disease
Rhoads, K., & Craft, S. (2008) · CRC Press eBooks · doi:10.3109/9781420091465-7 · Cited by 1
Therapeutic Potential of Phytochemicals: Lessons Learned from Streptozotocin-Induced Sporadic Alzheimer’s Disease
Javed, H., & Ojha, S. K. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_20 · Cited by 1
Is Alzhezimer’s disease a New Type Diabetes? Crosstalk between two serious disorders: review
Dobosz, M., Rudziński, G., Chilimoniuk, Z., Więsyk, P. J., Kusak, N., & Chałupnik, A. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.13.03.017 · Cited by 2
Beneficial effects of Insulin and Rivastigmine in Type-3 Diabetes mellitus in rats
Ahlawat, A., Walia, V., & Garg, M. (2023) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2023.112670 · Cited by 1
Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats
Fokin, Y. V., Kharitonov, S. Y., Taboyakova, L. A., & Karkischenko, N. N. (2023) · Journal Biomed · doi:10.33647/2074-5982-19-3-58-65 · Cited by 1
Brain Oxidative Stress in the Pathogenesis and Progression of Alzheimer’s Disease
Rukhsana Sultana, A., Swomley, A. M., & Butterfield, D. A. (2013) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-62703-598-9_8 · Cited by 1
Growth Hormone and Insulin-like Growth Factor-I in Alzheimer's Disease
Gómez, J. M. (2006) · Elsevier eBooks · doi:10.1016/b978-012088484-1/50026-4 · Cited by 1
Diabetes and Progression of Alzheimer's: Linking the Two Epidemics
Bandyopadhyay, S., Mistry, H., & Dutta, R. P. (2014) · Cited by 1
Combination Treatment with a Novel Polyherbal Formulation and Metformin: A Single Blind Placebo-Controlled Study in Patients with T2DM and Cognitive Impairments
Dubey, G. P., Sadhu, A., Upadhyay, P., Singh, P. K., Shivakumar, S., Agrawal, A., Ilango, K., & Mishra, V. (2015) · Diabetes Research - Open Journal · doi:10.17140/droj-1-116 · Cited by 1
Medical Family Therapy in Endocrinology
Zubatsky, M., & Mendenhall, T. J. (2018) · Focused issues in family therapy · doi:10.1007/978-3-319-68834-3_11 · Cited by 1
The Relationship Between Diabetes and Alzheimer's Disease
Kazkayası, İ., BOZKURT, N. B., & Uma, S. (2018) · Journal of Literature Pharmacy Sciences · doi:10.5336/pharmsci.2017-58894 · Cited by 1
Association between cognitive impairment patient with solid cancer and insulin resistance
Gonda, K., Yaginuma, K., Rokkaku, Y., Horita, S., Maejima, Y., & Shimomura, K. (2019) · BMC Research Notes · doi:10.1186/s13104-019-4739-5 · Cited by 2
Inflammation and insulin resistance in Alzheimer’s disease
Nash, Y., & Frenkel, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00025-6 · Cited by 1
Metabolic Pathways Underlying Neuropsychiatric Disorders and Obesity
Martins, L. B., Maurício, S. F., Ferreira, A. V. M., & Teixeira, A. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_30 · Cited by 1
TYPES OF DIABETES
Rajalakshmy, P. (2017) · Pondicherry Journal of Nursing · doi:10.5005/pjn-10-3-35 · Cited by 1
Influence of Selected Diets on Neural Insulin Activity and Cognitive Function
Parrott, M. D. (2014) · TSpace (University of Toronto) · Cited by 1
Development of lipid- and polymer-based nanocarriers for intranasal application
Akel, H. (2022) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.11343 · Cited by 1
The Janus Face of Insulin in Brain
Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch5
In Vivo Evidence of the Convergence of Type 2 Diabetes and Alzheimer Disease
Park, S. A. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch24
Aβ Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes
Sato, N., & Morishita, R. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch23
Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease
Solas, M., & Ramírez, M. J. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch6
Sinalização intracelular desencadeada por concentrações subtóxicas de estreptozotocina em células neuro-2A: modelo in vitro de neurodegeneração associada à doença de Alzheimer.
Mazucanti, C. H. (2013) · doi:10.11606/d.42.2013.tde-26092013-102423
Regulation of renal brush-border glucose transport in response to metabolic dysregulation
Chichger, H. (2011) · UCL Discovery (University College London)
Brain Cholinergic and Dopaminergic Functions in Streptozotocin Induced Diabetic Rats: Effects of Curcumin and Vitamin D3 Supplementation
Kumar, T. P., & Paulose, C. S. (2010) · Dyuthi Digital Repository (Cochin University of Science and Technology)
Neural substrates of insulin-mediated memory facilitation in early Alzheimer's disease; the impact of the apolipoprotein E-epsilon-4 allele on hippocampal insulin responses
Thomas, G. (2009) · KU ScholarWorks (University of Kansas)
Molecular changes during the development of Alzheimer's disease
Wirz, K. T. S. (2013) · Data Archiving and Networked Services (DANS)
Review Article Insulin resistance and pathological brain ageing
Cholerton, B., Baker, L. D., & Craft, S. (2011)
Transferencia de un gen neuro-protector en animales durante el envejecimiento reproductivo
Rodríguez, S. S. (2015) · doi:10.35537/10915/50396
Ignoring the Evidence Will Not Stop the Alzheimer's Disease/Diabetes Pandemic
de la Monte, S. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091703
Efficacy of Anti-Diabetic Medicines in the Treatment of Alzheimer's Disease
Aajami, Z., & Nikfar, S. (2015) · DOAJ (DOAJ: Directory of Open Access Journals)
Growth Hormone and Insulin-Like Growth Factor-I in Alzheimer's Disease
Saez, J. M. G. (2012) · The Open Endocrinology Journal · doi:10.2174/1874216501206010080
Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice
Wien, S.-V. (2015)
Effects of insulin gene dosage on body weight and glucose homeostasis
Mehran, A. E. (2015) · cIRcle (University of British Columbia) · doi:10.14288/1.0167270
Identification of Shared Molecular Pathways and Networks between Alzheimer's Disease and Type 2 Diabetes
Wei, K. W. (2016) · eScholarship (California Digital Library)
Chronic prenatal ethanol exposure produces neurobehavioural and metabolic dysfunction in guinea pig offspring
Dobson, C. C. (2014) · QSpace (Queen's University Library)
Efeitos do hormônio tireoideano T3 no sistema nervoso central associados a diabetes melito induzida por aloxana.
de Almeida, F. A. (2016) · doi:10.11606/d.42.2016.tde-09082016-113741
Growth Hormone and Insulin-Like Growth Factor-I: Effects on the Brain
Laron, Z. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00081-x
The Role of Insulin Resistance and Signaling in Dementia
Koenig, A. M., Arvanitakis, Z., & Arnold, S. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809454-9.00008-1
Interactions Between Age, Diet, and Insulin and Their Effect on Cognition
Félix‐Soriano, E., Moreno-Aliaga, M. J., Ramírez, M. J., & Solas, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00014-6
Efeito do agonista seletivo do receptor canabinoide 1 (CB1) em modelos de neurodegeneração induzida pela estreptozotocina.
Crunfli, F. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-14032018-110624
Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
Wang, Y. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3bg2hr4j
The Association of Diabetes in the Onset of Dementia in the Elderly Population
Kumar, A., & Sıngh, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812019-4.00008-8
Terapia celular y génica con timulina E IGF-1 en modelos animales de neuroinflamación
Villar, M. F. Z. (2018) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/71572
Hormones of energy homeostasis : linking weight loss and cognition in Parkinson's disease?
Johnston, F. (2018)
Preventing cognitive decline through resistance training
Marston, K. J. (2019) · Murdoch University Research Portal
Il clustering diseases in medicina interna come strumento di approccio alla complessità dei pazienti?
Tangianu, G. E. F., & Nardi, R. (2019) · Italian Journal of Medicine · doi:10.4081/itjm.q.2019.8
Mammalian target of rapamycin complexes
Querfurth, H. W., & Lee, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00021-9
p22phox y NADPH oxidasas en la hematopoyesis in vivo
Bermejo, R. (2020) · Gredos (University of Salamanca) · doi:10.14201/gredos.144241
Effects of Distinct n-6 to n-3 Polyunsaturated Fatty Acid Rations on Insulin Resistant and AD-like Phenotypes in High-Fat Diets-Fed APP/PS1 Transgenic MicePreprint
Ma, X., Guo, Y., Li, P., Xu, J., Dong, S., Gao, Y., Halm‐Lutterodt, N. V., & Yuan, L. (2021) · Research Square · doi:10.21203/rs.3.rs-582409/v1
The cerebral hypometabolism model of Alzheimer's disease explored: can a ketogenic diet improve cognition in Alzheimer's disease? A review of the literature
Brackley, K. (2021) · British Journal of Neuroscience Nursing · doi:10.12968/bjnn.2021.17.3.95
Neuroinflammation and insulin resistance underly cognitive impairment. Sex differences and potential treatments
Sánchez‐Sarasúa, S. (2021) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) · doi:10.6035/14112.2021.368012
A Non-Invasive Determination of Ketosis-Induced Elimination of Chronic Daytime Somnolence in a Patient with Late-Stage Dementia (Assessed with Type 3 Diabetes): A Potential Role of Neurogenesis
Lewis, L. A., Urban, C. M., & Hashim, S. A. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210315
“Defects in mitochondrial energy production have also been shown to contribute to the pathophysiology of AD, Parkinson’s disease, and Huntington’s disease [13,18)] and defective signaling is known to be a causative factor for AD [9,20].”
Background
Insulin gene expression and functional activity of insulin signaling pathway in Alzheimer's disease
Gorina, Y. V., Хилажева, Е. Д., Komleva, Y. K., Lopatina, O. L., & Salmina, A. B. (2021) · Fundamental and Clinical Medicine · doi:10.23946/2500-0764-2021-6-4-8-21
TOR-dependent cerebrovascular aging in Alzheimer's disease.
Jahrling, J. B., & Galván, V. (2014) · PubMed
Cardiac aging
Chiao, Y. A., Dai, D., Wessells, R. J., & Rabinovitch, P. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00015-9
Diabetic Encephalopathy Affects Mitochondria and Axonal Transport Proteins
Eslami, M., Nahavandi, A., Nejad, T. B., & Roghani, M. (2019) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.10.460
Faculty Opinions recommendation of Insulin resistance and neurodegeneration: progress towards the development of new therapeutics for alzheimer's disease.
Rosenzweig, S. A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727123638.793572332
SÍNTESE E CARACTERIZAÇÃO DE POTENCIAIS METAL-PROTEIN ATTENUATING COMPOUNDS HIDRAZÔNICOS E AVALIAÇÃO DA COMPLEXAÇÃO AO ÍON VANADILA COMO POSSÍVEL FORMA DE ADMINISTRAÇÃO NO CONTEXTO DA DOENÇA DE ALZHEIMER
MALHEIROS, G. D. S. (2018) · doi:10.17771/pucrio.acad.35906
Faculty Opinions recommendation of Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums.
Rosenzweig, S. A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732579862.793572336
Gene dosage determines the behavioural phenotype in the 5xFAD mouse model of Alzheimer’s disease: analysis of the contribution of brain insulin signalling and gut microbiotaPreprint
Vera, D. M., Zambrana-Infantes, E. N., López-Gambero, A. J., Gonzalez-Jimenez, A., Navarro, J. A., Pavón, F. J., Baixerás, E., Santín, L. J., Suárez, J., Rosell‐Valle, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2087511/v1
Brain Insulin Resistance, Nitric Oxide and Alzheimer’s Disease Pathology
Pei, Z., Lee, K.-C., Khan, A., & Wang, H.-Y. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815079814122010014
Impacts of Dietary Chrysophyllum albidum Fruit Pulp on Brain Cholinesterase Function in High-Fat Diet/Streptozotocin-Induced Diabetic Rats
Akomolafe, S. F., Oyeleye, S. I., Odeniyi, I. A., Oladapo, I. F., Akinyemi, A. J., Oyetayo, F. L., & Ajayi, O. B. (2022) · Tanzania Journal of Science · doi:10.4314/tjs.v48i4.12
The effect of intra-nasal insulin & growth factor-rich serum administration on memory and behavior defects induced by icv-STZ rat model and correlation analysis of hippocampus oxidative-nitrosative state with spatial memory and anxiogenic behaviorPreprint
Ghaffari, M. K., Rafati, A., Karbalaei, N., Haghani, M., Nemati, M., Sefati, N., & Namavar, M. R. (2023) · Research Square · doi:10.21203/rs.3.rs-2875665/v1
The effect of intra-nasal co-treatment with insulin and growth factor-rich serum on behavioral defects, hippocampus histological, and oxidative-nitrosative stress changes induced by icv-STZ in a rat modelPreprint
Ghaffari, M. K., Rafati, A., Karbalaei, N., Haghani, M., Nemati, M., Sefati, N., & Namavar, M. R. (2023) · Research Square · doi:10.21203/rs.3.rs-3238680/v1
Metabolic association between diabetes mellitus and alzheimer’s disease: neuropathological interaction?
Yngrid Carneiro de Aguiar, I. S. D. O. A. A. O. B. (2023) · International Journal of Development Research · doi:10.37118/ijdr.27098.08.2023
“…generates neurodegeneration and reduced expression of TAU, a protein that controls the dynamics of microtubules during the maturation and growth of neurites (13), which is regulated by IGF-1 (Insulin-like growth factor) associating it also, in this way, to the development of AD (14), (15), (16).”
Influential
Sobrecarga de cobre y enfermedad de Alzheimer, búsqueda de posibles blancos terapéuticos
Zubillaga, M. (2023) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/165188
Comprehending the Rationale for Repurposing Type 2 Diabetes Mellitus Medicines for Alzheimer's Disease Patients Via Gene Networks Studies and its Associated Molecular Pathways
Yadav, R., Mani, R. J., Kumar, A. H. S., Ahmad, S., & Katare, D. P. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2990 · Cited by 1
IGF-II conjugated nanocarrier for brain targeting
Akotkar, L., Aswar, U. M., Shruti, S. D., Tushar, S., & Dhanshree, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00004-2
Culprits of Neurodegeneration in Alzheimer’s Diseases: Bench to Bedside Impression
Kumar, A., & Roy, A. (2025) · Central India Journal of Medical Research · doi:10.58999/cijmr.v4i01.224
Growth Hormone Deficiency and Therapy During Aging
Herodes, M., Leonardi, C., & Garcia, J. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-89650-7_25

Authors: Rivera, E. J., Goldin, A., Fulmer, N., Tavares, R., Wands, J. R., & de la Monte, S. M.
Affiliations: Brown University (US)
Departments of Pathology and Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI, USA
ORCID: Wands, Jack R.
Venue: Journal of Alzheimer s Disease
Publisher: SAGE Publications
Published: 2005-12-05
Volume: 8
Issue: 3
Pages: 247-268
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2005-8304
OpenAlex: W1718410121
Cited by: 723
References: 71
Citations by year: 2026: 16 · 2025: 24 · 2024: 32 · 2023: 35 · 2022: 56 · 2021: 45 · 2020: 43 · 2019: 52 · 2018: 46 · 2017: 29 · 2016: 43 · 2015: 44 · 2014: 51 · 2013: 42 · 2012: 43
FWCI: 8.79
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (AA12458, AA-02666, AA11931)
National Institute on Aging (P50 AG05128, P50AG005128)
National Center for Research Resources (P20RR 15578, P20RR015578)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, insulin
MeSH terms: Acetylcholine, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Apolipoproteins E, Brain, Choline O-Acetyltransferase, Cognition Disorders, Female, Genotype, Glucose, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, RNA, Messenger, Gene Expression, Amyloid beta-Protein Precursor, tau Proteins, DNA Primers, Disease Progression, Reverse Transcriptase Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer’s disease: Link to brain reductions in acetylcholine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks