Regulation of neuronal survival by the serine-threonine protein kinase Akt
Abstract
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70(S6K)). Experiments with pharmacological inhibitors, as well as expression of wild-type and dominant-inhibitory forms of Akt, demonstrated that Akt but not p70(S6K) mediates PI3-K-dependent survival. These findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AKT is a critical mediator of neuronal survival.
“which is a critical mediator of neuronal survival (Datta et al., 1997; Dudek et al., 1997).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Dudek et al., 1997
Cites
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444 · see citing works
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works
Self-citationInhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
Burgering, B. M. T., & Coffer, P. J. (1995) · Nature · doi:10.1038/376599a0 · Cited by 2,113 · see citing works
Franke, T. F., Yang, S., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., & Tsichlis, P. N. (1995) · Cell · doi:10.1016/0092-8674(95)90534-0 · Cited by 2,006 · see citing works
Self-citationWhite, M. F., & Kahn, C. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42297-6 · Cited by 1,723 · see citing works
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate
Franke, T. F., Kaplan, D., Cantley, L., & Toker, A. (1997) · Science · doi:10.1126/science.275.5300.665 · Cited by 1,609 · see citing works
Self-citationChung, J., Kuo, C. J., Crabtree, G. R., & Blenis, J. (1992) · Cell · doi:10.1016/0092-8674(92)90643-q · Cited by 1,151 · see citing works
A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region
Bellacosa, A., Testa, J. R., Staal, S. P., & Tsichlis, P. N. (1991) · Science · doi:10.1126/science.1833819 · Cited by 939 · see citing works
Wood, K. W., Sarnecki, C., Roberts, T. M., & Blenis, J. (1992) · Cell · doi:10.1016/0092-8674(92)90076-o · Cited by 903 · see citing works
D'Mello, S. R., Galli, C., Ciotti, T., & Calissano, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10989 · Cited by 892 · see citing works
Xia, Z., Dudek, H., Miranti, C. K., & Greenberg, M. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05425.1996 · Cited by 794 · see citing works
Self-citationPDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
Chung, J., Grammar, T. C., Lemon, K. P., Kazlauskas, A., & Blenis, J. (1994) · Nature · doi:10.1038/370071a0 · Cited by 719 · see citing works
Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras
Rosen, L. B. (1994) · Neuron · doi:10.1016/0896-6273(94)90438-3 · Cited by 716 · see citing works
Carpenter, C. L., & Cantley, L. C. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80060-3 · Cited by 547 · see citing works
Jones, P. F., Jakubowicz, T., Pitossi, F. J., Maurer, F., & Hemmings, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4171 · Cited by 532 · see citing works
Andjelkovic, M., Jakubowicz, T., Cron, P., Ming, X., Han, J. W., & Hemmings, B. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.12.5699 · Cited by 525 · see citing works
Coffer, P. J., & Woodgett, J. R. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16305.x · Cited by 493 · see citing works
Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation
Kohn, A. D., Takeuchi, F., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21920 · Cited by 476 · see citing works
Carson, M. J., Behringer, R. R., Brinster, R. L., & McMorris, F. A. (1993) · Neuron · doi:10.1016/0896-6273(93)90173-o · Cited by 474 · see citing works
PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface
Lemmon, M. A., Ferguson, K. M., & Schlessinger, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81022-3 · Cited by 467 · see citing works
Galli, C., Meucci, O., Scorziello, A., Werge, T., Calissano, P., & Schettini, G. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01172.1995 · Cited by 400 · see citing works
A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury
Gluckman, P. D., Klempt, N. D., Guan, J., Mallard, C. E., Sirimanne, E. S., Dragunow, M., Klempt, M., Singh, K., Williams, C., & Nikolics, K. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91774-k · Cited by 384 · see citing works
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
Bellacosa, A., Testa, Staal, S., et al. (1991) · Science · doi:10.1126/science.254.5029.274 · Cited by 365 · see citing works
Kohn, A. D., Kovacina, K. S., & Roth, R. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00103.x · Cited by 355 · see citing works
The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors
de Pablo, F., & de la Rosa, E. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93892-2 · Cited by 238 · see citing works
Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras
Ming, X., Burgering, B. M. T., Wennström, S., Claesson, L., Heldin, C. H., Bos, J. L., Kozma, S. C., & Thomas, G. (1994) · Nature · doi:10.1038/371426a0 · Cited by 206 · see citing works
Konishi, H., Matsuzaki, H., Tanaka, M., Ono, Y., Tokunaga, C., Kuroda, S., & Kikkawa, U. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7639 · Cited by 192 · see citing works
ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons
Borasio, G. D., John, J., Wittinghofer, A., Barde, Y., Sendtner, M., & Heumann, R. (1989) · Neuron · doi:10.1016/0896-6273(89)90233-x · Cited by 189 · see citing works
AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation
Datta, K., Franke, T. F., Chan, T. O., Makris, A. M., Yang, S.-I., Kaplan, D. R., Morrison, D. K., Golemis, E. A., & Tsichlis, P. N. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2304 · Cited by 164 · see citing works
Self-citationAhmed, N. N., Franke, T. F., Bellacosa, A., Datta, K., Gonzalez-Portal, M. E., Taguchi, T., Testa, J. R., & Tsichlis, P. N. (1993) · PubMed · Cited by 160 · see citing works
Self-citationYao, R., & Gm, C. (1996) · PubMed · Cited by 120 · see citing works
Schumacher, R., Soos, M. A., Schlessinger, J., Brandenburg, D., Siddle, K., & Ullrich, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54045-x · Cited by 118 · see citing works
Torres‐Alemán, I., Pons, S., & Arévalo, M. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490390202 · Cited by 113 · see citing works
Inhibition of p38 Mitogen-activated Protein Kinase by Insulin in Cultured Fetal Neurons
Heidenreich, K. A., & Kummer, J. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9891 · Cited by 109 · see citing works
Blenis, J., Kuo, C. J., & Erikson, R. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47802-7 · Cited by 100 · see citing works
Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons
Nobes, C. D., Reppas, J. B., Markus, A., & Tolkovsky, A. M. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00420-3 · Cited by 47 · see citing works
Monoclonal antibodies reveal the global organization of the cerebellar cortex
Gravel, C., Leclerc, N. M., Rafrafi, J., et al. (1987) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(87)90112-9 · Cited by 37 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works
Self-citationCellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works
Self-citationNegative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551 · see citing works
Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
Diehl, J. A., Cheng, M., Roussel, M. F., & Sherr, C. J. (1998) · Genes & Development · doi:10.1101/gad.12.22.3499 · Cited by 2,130 · see citing works
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944 · see citing works
Self-citationSteen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703 · see citing works
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583 · see citing works
Akt Stimulates Aerobic Glycolysis in Cancer Cells
Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2904 · Cited by 1,454 · see citing works
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284 · see citing works
Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181181198 · Cited by 1,230 · see citing works
Ten years of protein kinase B signalling: a hard Akt to follow
Brazil, D. P., & Hemmings, B. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01958-2 · Cited by 1,177 · see citing works
Alzheimer’s disease is type 3 diabetes—Evidence reviewed
de la Monte, S. M., & Wands, J. R. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200619 · Cited by 1,158 · see citing works
Cheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F., Roberts, J. M., & Sherr, C. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1571 · Cited by 1,142 · see citing works
Heras-Sandoval, D., Pérez-Rojas, J. M., Hernández-Damián, J., & Pedraza-Chaverri, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.08.019 · Cited by 1,091 · see citing works
Role of Translocation in the Activation and Function of Protein Kinase B
Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J. C., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31515 · Cited by 1,051 · see citing works
Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., & Hay, N. (2001) · Genes & Development · doi:10.1101/gad.889901 · Cited by 961 · see citing works
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953 · see citing works
The many faces of insulin-like peptide signalling in the brain
Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
“This protein antagonizes the activity of the serine-threonine kinase AKT (Stambolic et al., 1998), which is a critical mediator of neuronal survival (Datta et al., 1997; Dudek et al., 1997).”
Liu, Y., Wong, T. P., Aarts, M., Rooyakkers, A., Liu, L., Lai, T. W., Wu, D. C., Lu, J., Tymianski, M., Craig, A. M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0116-07.2007 · Cited by 773 · see citing works
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F., Rovira, I. I., Nguyen, A. T., Malide, D., Combs, C. A., Hall, G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051921 · Cited by 747 · see citing works
Zeng, G., Nystrom, F. H., Ravichandran, L. V., Cong, L.-N., Kirby, M., Mostowski, H., & Quon, M. J. (2000) · Circulation · doi:10.1161/01.cir.101.13.1539 · Cited by 745 · see citing works
Rivera, E. J., Goldin, A., Fulmer, N., Tavares, R., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8304 · Cited by 723 · see citing works
Vascular endothelial growth factor: Direct neuroprotective effect in <i>in vitro</i> ischemia
Jin, K. L., Mao, X. O., & Greenberg, D. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.10242 · Cited by 684 · see citing works
Kempf, T., Eden, M., Strelau, J., Naguib, M., Willenbockel, C., Tongers, J., Heineke, J., Kotlarz, D., Xu, J., Molkentin, J. D., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000202805.73038.48 · Cited by 651 · see citing works
The role of insulin receptor signaling in the brain
Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604 · see citing works
Skorski, T., Bellacosa, A., Nieborowska‐Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6151 · Cited by 567 · see citing works
Depolarization and cAMP Elevation Rapidly Recruit TrkB to the Plasma Membrane of CNS Neurons
Meyer-Franke, A., Wilkinson, G. A., Kruttgen, A., Hu, M., Munro, E., Hanson, M. G., Reichardt, L. F., & Barres, B. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80586-3 · Cited by 516 · see citing works
Kinase mutations in human disease: interpreting genotype–phenotype relationships
Lahiry, P., Torkamani, A., Schork, N. J., & Hegele, R. A. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2707 · Cited by 420 · see citing works
The molecular bases of Alzheimer’s disease and other neurodegenerative disorders
Maccioni, R. B., Muñoz, J. P., & Barbeito, L. (2001) · Archives of Medical Research · doi:10.1016/s0188-4409(01)00316-2 · Cited by 474 · see citing works
Insulin resistance and Alzheimer's disease
De La Monte, S. M. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.8.475 · Cited by 392 · see citing works
Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms
Cassilhas, R. C., Lee, K. S., Fernandes, J., Oliveira, M. G. M., Tufik, S., Meeusen, R., & de Mello, M. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.029 · Cited by 394 · see citing works
Expression of CX <sub>3</sub> CR1 chemokine receptors on neurons and their role in neuronal survival
Meucci, O., Fatatis, A., Simen, A. A., & Miller, R. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090017497 · Cited by 385 · see citing works
Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ
Meier, R., Alessi, D. R., Cron, P., Andjelković, M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30491 · Cited by 378 · see citing works
Wang, J.-M., Chao, J.-R., Chen, W., Kuo, M.-L., Yen, J. J.-Y., & Yang-Yen, H.-F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6195 · Cited by 357 · see citing works
PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy
Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K., & Donner, D. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108302200 · Cited by 351 · see citing works
Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease
Rojo, L. E., Fernández, J. A., Maccioni, A. A., Jimenez, J. M., & Maccioni, R. B. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.10.001 · Cited by 351 · see citing works
Wilkins, A., Majed, H., Layfield, R., Compston, A., & Chandran, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04967.2003 · Cited by 337 · see citing works
Pyramidal cell regulation of interneuron survival sculpts cortical networks
Wong, F. K., Bercsenyi, K., Sreenivasan, V., Portalés, A., Fernández-Otero, M., & Marín, O. (2018) · Nature · doi:10.1038/s41586-018-0139-6 · Cited by 286 · see citing works
Butovsky, O. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26836 · Cited by 261 · see citing works
Kadekaro, A. L., Kavanagh, R., Kanto, H., Terzieva, S., Hauser, J., Kobayashi, N., Schwemberger, S., Cornelius, J., Babcock, G., Shertzer, H. G., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4535 · Cited by 259 · see citing works
Yamaguchi, A., Tamatani, M., Matsuzaki, H., Namikawa, K., Kiyama, H., Vitek, M. P., Mitsuda, N., & Tohyama, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008552200 · Cited by 242 · see citing works
Liu, D., Pitta, M., Jiang, H., Lee, J.-H., Zhang, G., Chen, X., Kawamoto, E. M., & Mattson, M. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.020 · Cited by 238 · see citing works
Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications
Neumann, K., Rojo, L., Navarrete, L., Farias, G., Reyes, P., & Maccioni, R. (2008) · Current Alzheimer Research · doi:10.2174/156720508785908919 · Cited by 236 · see citing works
Insulin/IGF-like signalling, the central nervous system and aging
Broughton, S., & Partridge, L. (2009) · Biochemical Journal · doi:10.1042/bj20082102 · Cited by 228 · see citing works
Malagelada, C., Jin, Z. H., & Greene, L. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3928-08.2008 · Cited by 228 · see citing works
Zheng, W., & Quirion, R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02350.x · Cited by 225 · see citing works
Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?
Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., & Smith, M. A. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.01.001 · Cited by 212 · see citing works
Transcriptional effects of chronic Akt activation in the heart
Cook, S. A., Matsui, T., Li, L., & Rosenzweig, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201462200 · Cited by 199 · see citing works
Improving peripheral nerve regeneration: From molecular mechanisms to potential therapeutic targets
Chan, K. M., Gordon, T., Zochodne, D. W., & Power, H. A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.09.006 · Cited by 189 · see citing works
MC1R and the response of melanocytes to ultraviolet radiation
Rouzaud, F., Kadekaro, A. L., Abdel-Malek, Z. A., & Hearing, V. J. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.014 · Cited by 173 · see citing works
Mammary gland involution is delayed by activated Akt in transgenic mice
Schwertfeger, K. L., Richert, M. M., & Anderson, S. M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.6.0663 · Cited by 169 · see citing works
Reglodi, D., Renaud, J., Tamas, A., Tizabi, Y., Socías, S. B., Del-Bel, E., & Raisman-Vozari, R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.004 · Cited by 162 · see citing works
Effect of Intranasal Insulin on Cognitive Function: A Systematic Review
Shemesh, E., Rudich, A., Harman-Boehm, I., & Cukierman-Yaffe, T. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1802 · Cited by 162 · see citing works
Hartigan, J. A., & Johnson, G. V. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21395 · Cited by 141 · see citing works
The pro‐apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
Cinar, B., Fang, P., Lutchman, M., Di Vizio, D., Adam, R. M., Pavlova, N., Rubin, M. A., Yelick, P. C., & Freeman, M. R. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601872 · Cited by 136 · see citing works
Neuregulin Rescues PC12-ErbB4 Cells from Cell Death Induced by H2O2
Goldshmit, Y., Erlich, S., & Pinkas-Kramarski, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105637200 · Cited by 127 · see citing works
Glycogen synthase kinase 3β is tyrosine phosphorylated by PYK2
Hartigan, J. A., Xiong, W.-C., & Johnson, G. V. W. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4986 · Cited by 117 · see citing works
Neuroprotective Effects of Exercise Treatments after Injury: The Dual Role of Neurotrophic Factors
Cobianchi, S., Arbat-Plana, A., Lopez-Alvarez, V. M., & Navarro, X. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160330105132 · Cited by 94 · see citing works
Crossing paths: interactions between the cell death machinery and growth factor survival signals
Brumatti, G., Salmanidis, M., & Ekert, P. G. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0288-8 · Cited by 85 · see citing works
Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity
Kang, S. J., Ryoo, I.-G., Lee, Y. J., & Kwak, M.-K. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.10.011 · Cited by 76 · see citing works
Pistono, C., Bister, N., Stanová, I., & Malm, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.623771 · Cited by 75 · see citing works
Cui, D., Thorp, E., Li, Y., Wang, N., Yvan-Charvet, L., Tall, A. R., & Tabas, I. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307192 · Cited by 73 · see citing works
DeGregorio-Rocasolano, N., Gasull, T., & Trullas, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007967200 · Cited by 56 · see citing works
R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells
Kimmelman, A. C., Osada, M., & Chan, A. M.-L. (2000) · Oncogene · doi:10.1038/sj.onc.1203530 · Cited by 50 · see citing works
Zhang, J., Feng, X., Wu, J., Xu, H., Li, G., Zhu, D., Yue, Q., Liu, H., Zhang, Y., Sun, D., et al. (2014) · BioFactors · doi:10.1002/biof.1149 · Cited by 50 · see citing works
Therapies modulating insulin resistance in Parkinson’s disease: A cross talk
Sharma, T., Kaur, D., Grewal, A. K., & Singh, T. G. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135754 · Cited by 44 · see citing works
Zhong, J., Deng, J., Phan, J., Dlouhy, S., Wu, H., Yao, W., Ye, P., D'Ercole, A. J., & Lee, W. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20490 · Cited by 41 · see citing works
Soeda, Y., Tsuneki, H., Muranaka, H., Mori, N., Hosoh, S., Ichihara, Y., Kagawa, S., Wang, X., Toyooka, N., Takamura, Y., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0163 · Cited by 38 · see citing works
Kim, G. S., Cho, S., Nelson, J. W., Zipfel, G. J., & Han, B. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088962 · Cited by 27 · see citing works
Yan, P., Tang, S., Zhang, H., Guo, Y., Zeng, Z., & Wen, Q. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9935-6 · Cited by 17 · see citing works
Querfurth, H., Marshall, J., Parang, K., Rioult-Pedotti, M. S., Tiwari, R., Kwon, B., Reisinger, S., & Lee, H.-K. (2022) · PLOS ONE · doi:10.1371/journal.pone.0261696 · Cited by 9 · see citing works
- Authors
- Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E.
- Affiliations
- Harvard University (US)
- Montreal Neurological Institute and Hospital (CA)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Datta, Sandeep Robert
- Franke, Thomas F.
- Greenberg, Michael E.
- ORCID
- Venue
- Science
- Published
- 1997-01-31
- Volume
- 275
- Issue
- 5300
- Pages
- 661-665
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048121649
- Cited by
- 2,436
- References
- 38
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 15 · 2023: 27 · 2022: 27 · 2021: 23 · 2020: 29 · 2019: 47 · 2018: 42 · 2017: 50 · 2016: 51 · 2015: 62 · 2014: 76 · 2013: 87 · 2012: 61
- FWCI
- 66.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca043855-12, 7r01dk039519-08)
- National Cancer Institute (R01CA018689, R01 CA 43855, R01 CA 18689)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK39519)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Keywords
- Akt, neuronal survival, insulin-like growth factor I, phosphatidylinositol 3-kinase, cerebellar neurons, growth factor signaling, dominant-negative Akt, neuroprotection
- MeSH terms
- Wortmannin, Androstadienes, Animals, Cell Survival, Cells, Cultured, Cerebellum, Chromones, Enzyme Activation, Enzyme Inhibitors, Insulin, Insulin-Like Growth Factor I, Morpholines, Neurons, Proto-Oncogene Proteins, Transfection, Signal Transduction, Apoptosis, Protein Serine-Threonine Kinases, Phosphotransferases (Alcohol Group Acceptor), Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Ribosomal Protein S6 Kinases, Proto-Oncogene Proteins c-akt, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review