The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease
Abstract
Excitatory neurotransmitter dysfunction has been discussed to be involved in the pathophysiology of Alzheimer's disease (AD). In the current study we investigated gene and protein expression patterns of glutamatergic receptors and transporters in brains of AD patients in various stages of disease using gene chip arrays, real time PCR and immunohistochemistry. We found marked impairment in the expression of excitatory amino acid transporters (EAAT1 and EAAT 2) at both gene and protein levels in hippocampus and gyrus frontalis medialis of AD patients, already in early clinical stages of disease. The loss of EAAT immunoreactivity was particularly obvious in the vicinity of amyloid plaques. In contrast, EAAT expression was up-regulated in the cerebellum of these patients. Furthermore, a significant up-regulation of the glutamatergic kainate (GRIK4) receptor observed by gene arrays was confirmed by quantitative RT-PCR in late stages in the hippocampus of AD patients. Moreover, there were down-regulations of other glutamatergic receptors such as NMDA (GRINL1A) and AMPA (GRIA4) receptors. Our data show marked changes in the functional elements of the glutamatergic synapses such as glutamatergic receptors and transporters and indicate impaired glutamate clearing rendering neurons susceptible to excess extracellular glutamate and support further the involvement of excitotoxic mechanisms in the pathogenesis of AD.
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“Loss or dysfunction of SLC1A2 has been implicated in multiple neurodegenerative and neuropsychiatric disorders, including AD where it is closely associated with cognitive decline [126–131].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [128]
In the citing paper
“Downregulation of the GluN1 subunit is observed in AD patient brain at different stages of neurodegenerative onset [60].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [60]
Citations
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Inflammaging, Neuroinflammation, and Synaptic Damage in Alzheimer's Disease
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Edible Bird’s Nest Enhances Memory and Learning in a Rat Model of Sporadic Alzheimer’s DiseasePreprint
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Bone Marrow-Derived Cells with GLT1 Gene Delivery for Amyotrophic Lateral Sclerosis
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Metadata
- Authors
- Jacob, C. P., Koutsilieri, E., Bartl, J., Neuen-Jacob, E., Arzberger, T., Zander, N., Ravid, R., Roggendorf, W., Riederer, P., & Grünblatt, E.
- Affiliations
- University of Würzburg (DE)
- Heinrich Heine University Düsseldorf (DE)
- Netherlands Brain Bank (NL)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2007-03-01
- Volume
- 11
- Issue
- 1
- Pages
- 97-116
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W118386170
- Cited by
- 317
- References
- 40
- Citations by year
- 2026: 11 · 2025: 31 · 2024: 14 · 2023: 19 · 2022: 29 · 2021: 23 · 2020: 26 · 2019: 18 · 2018: 19 · 2017: 14 · 2016: 14 · 2015: 17 · 2014: 11 · 2013: 11 · 2012: 8
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Reference Values, Receptors, Glutamate, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Glutamate Plasma Membrane Transport Proteins, Plaque, Amyloid
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