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Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease
Abstract
Excitatory neurotransmitter dysfunction has been discussed to be involved in the pathophysiology of Alzheimer's disease (AD). In the current study we investigated gene and protein expression patterns of glutamatergic receptors and transporters in brains of AD patients in various stages of disease using gene chip arrays, real time PCR and immunohistochemistry. We found marked impairment in the expression of excitatory amino acid transporters (EAAT1 and EAAT 2) at both gene and protein levels in hippocampus and gyrus frontalis medialis of AD patients, already in early clinical stages of disease. The loss of EAAT immunoreactivity was particularly obvious in the vicinity of amyloid plaques. In contrast, EAAT expression was up-regulated in the cerebellum of these patients. Furthermore, a significant up-regulation of the glutamatergic kainate (GRIK4) receptor observed by gene arrays was confirmed by quantitative RT-PCR in late stages in the hippocampus of AD patients. Moreover, there were down-regulations of other glutamatergic receptors such as NMDA (GRINL1A) and AMPA (GRIA4) receptors. Our data show marked changes in the functional elements of the glutamatergic synapses such as glutamatergic receptors and transporters and indicate impaired glutamate clearing rendering neurons susceptible to excess extracellular glutamate and support further the involvement of excitotoxic mechanisms in the pathogenesis of AD.
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“Loss or dysfunction of SLC1A2 has been implicated in multiple neurodegenerative and neuropsychiatric disorders, including AD where it is closely associated with cognitive decline [126–131].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [128]
In the citing paper
“Downregulation of the GluN1 subunit is observed in AD patient brain at different stages of neurodegenerative onset [60].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [60]
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Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
High density synthetic oligonucleotide arrays
Lipshutz, R. J., Fodor, S. P. A., Gingeras, T., & Lockhart, D. J. (1999) · Nature Genetics · doi:10.1038/4447 · Cited by 2,204
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656
Gene-expression profile of the ageing brain in mice
Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond
Lipton, S. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1958 · Cited by 909
Lee, M. T., Kuo, F. C., Whitmore, G. A., & Sklar, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.9834 · Cited by 861
Kainic Acid-Mediated Excitotoxicity as a Model for Neurodegeneration
Wang, Q., Yu, S. O., Simonyi, Á., Sun, G. Y., & Sun, A. Y. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:003 · Cited by 365
Grünblatt, E., Mandel, S. A., Jacob‐Hirsch, J., Zeligson, S., Amariglo, N., Rechavi, G., Li, J., Ravid, R., Roggendorf, W., Riederer, P. F., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0212-1 · Cited by 355
Self-citationPattern of brain destruction in Parkinson's and Alzheimer's diseases
Braak, H., Braak, E., Yilmazer‐Hanke, D., de Vos, R. A. I., Jansen, E. N. H., & Böhl, J. (1996) · Journal of Neural Transmission · doi:10.1007/bf01276421 · Cited by 326
Computational methods for theidentification of differential and coordinated gene expression
Claverie, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.10.1821 · Cited by 287
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Items 101–200 of 317
Role of Thiamine in Alzheimer's Disease
Lương, K. V. Q., & Nguyễn, L. (2011) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317511432736 · Cited by 65
The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review
Hulshof, L. A., van Nuijs, D., Hol, E. M., & Middeldorp, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.899251 · Cited by 66
Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease
Dejakaisaya, H., Kwan, P., & Jones, N. C. (2021) · Epilepsia · doi:10.1111/epi.16918 · Cited by 64
Reactive Astrocytes as Drug Target in Alzheimer’s Disease
Assefa, B. T., Gebre, A. K., & Altaye, B. M. (2018) · BioMed Research International · doi:10.1155/2018/4160247 · Cited by 66
G‐protein‐coupled receptors and melanoma
Lee, H. J., Wall, B., & Chen, S. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2008.00478.x · Cited by 63
Duerson, K. C., Woltjer, R. L., Mookherjee, P., Leverenz, J. B., Montine, T. J., Bird, T. D., Pow, D. V., Rauen, T., & Cook, D. G. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00186.x · Cited by 60
Transcriptome profiling in neurodegenerative disease
Courtney, E., Kornfeld, S., Janitz, K., & Janitz, M. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.08.018 · Cited by 64
The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms
Yu, Y., Chen, R., Mao, K., Deng, M., & Li, Z. (2023) · Aging and Disease · doi:10.14336/ad.2023.0718 · Cited by 62
Comparison Analysis of Gene Expression Patterns between Sporadic Alzheimer's and Parkinson's Disease
Grünblatt, E., Zander, N., Bartl, J., Li, J., Monoranu, C., Arzberger, T., Ravid, R., Roggendorf, W., Gerlach, M., & Riederer, P. F. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12402 · Cited by 59
Self-citationSasaoka, M., Nakamura, K., Shimazawa, M., Ito, Y., Araie, M., & Hara, H. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.02.004 · Cited by 59
Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus
Mayordomo‐Cava, J., Yajeya, J., Navarro‐López, J. D., & Jiménez‐Díaz, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134385 · Cited by 55
Crescenzi, R. L., DeBrosse, C., Nanga, R. P. R., Byrne, M. D., Krishnamoorthy, G., D’Aquilla, K., Nath, H., Morales, K. H., Iba, M., Hariharan, H., et al. (2016) · Hippocampus · doi:10.1002/hipo.22693 · Cited by 60
From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain
Riederer, P. F., & Hoyer, S. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0591-6 · Cited by 56
Self-citationNirzhor, S. S. R., Khan, R. I., & Neelotpol, S. (2018) · Biomolecules · doi:10.3390/biom8030093 · Cited by 57
Effects of memantine on the excitation-inhibition balance in prefrontal cortex
Povysheva, N. V., & Johnson, J. W. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.08.006 · Cited by 59
Liu, Y., Wang, S., Kan, J., Zhang, J., Zhou, L., Huang, Y., & Zhang, Y. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191101125530 · Cited by 56
Khundakar, A. A., & Thomas, A. J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-148003 · Cited by 53
Dahlmanns, M., Dahlmanns, J. K., Savaskan, N. E., Steiner, H. H., & Yakubov, E. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2803057 · Cited by 53
Astrocytic glutamatergic transporters are involved in Aβ-induced synaptic dysfunction
Huang, S., Tong, H., Lei, M., Zhou, M., Guo, W., Li, G., Tang, X., Li, Z., Mo, M., Zhang, X., et al. (2017) · Brain Research · doi:10.1016/j.brainres.2017.10.011 · Cited by 52
Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?
Mather, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.013 · Cited by 57
Pajarillo, E. A. B., Johnson, J., Rizor, A., Nyarko‐Danquah, I., Adinew, G. M., Bornhorst, J., Stiboller, M., Schwerdtle, T., Son, D., Aschner, M., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015552 · Cited by 50
Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse
Varga, E., Juhász, G., Bozsó, Z., Penke, B., Fülöp, L., & Szegedi, V. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142367 · Cited by 51
Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression
Ryan, R. M., Ingram, S., & Scimemi, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.670346 · Cited by 54
Pharmacotherapy of Alzheimer’s disease: an overview of systematic reviews
Majidazar, R., Rezazadeh‐Gavgani, E., Sadigh‐Eteghad, S., & Naseri, A. (2022) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-022-03363-6 · Cited by 54
Riluzole: a therapeutic strategy in Alzheimer’s disease by targeting the WNT/β-catenin pathway
Vallée, A., Vallée, J.-N., Guillevin, R., & Lecarpentier, Y. (2020) · Aging · doi:10.18632/aging.102830 · Cited by 50
Peng, J.-J., Lin, S.-H., Liu, Y., Lin, H.-C., Li, T.-N., & Yao, C. (2019) · eLife · doi:10.7554/elife.47372 · Cited by 42
Bioactive human Alzheimer brain soluble Aβ: pathophysiology and therapeutic opportunities
Li, S., & Stern, A. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01589-5 · Cited by 47
The Role of Reelin Signaling in Alzheimer’s Disease
Yu, N., Tan, M., Yu, J., Xie, A., & Tan, L. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9459-9 · Cited by 47
Amyloid Plaques of Alzheimer’s Disease as Hotspots of Glutamatergic Activity
Ovsepian, S. V., O’Leary, V. B., Záborszky, L., Ntziachristos, V., & Dolly, J. O. (2018) · The Neuroscientist · doi:10.1177/1073858418791128 · Cited by 45
Brothers, H. M., Bardou, I., Hopp, S. C., Kaercher, R. M., Corona, A. W., Fenn, A. M., Godbout, J. P., & Wenk, G. L. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9476-2 · Cited by 44
Astrocyte and oligodendrocyte pathology in Alzheimer's disease
Ziar, R., Tesar, P. J., & Clayton, B. L. L. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00540 · Cited by 47
Basselin, M., Ramadan, E., & Rapoport, S. I. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.12.001 · Cited by 43
Qu, X., Xu, C., Wang, H., Xu, J., Liu, W., Wang, Y., Jia, X., Xie, Z., Xu, Z., Ji, C., et al. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0889-8 · Cited by 42
Tong, H., Zhang, X., Meng, X., Xu, P., Zou, X., & Qu, S. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.01.017 · Cited by 42
Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis
Peterson, A. R., & Binder, D. K. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.05.048 · Cited by 42
Reelin Signaling in Neurodevelopmental Disorders and Neurodegenerative Diseases
Joly‐Amado, A., Kulkarni, N., & Nash, K. R. (2023) · Brain Sciences · doi:10.3390/brainsci13101479 · Cited by 47
Lesuis, S. L., Kaplick, P. M., Lucassen, P. J., & Krugers, H. J. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.023 · Cited by 40
Frisardi, V., Panza, F., & Farooqui, A. A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.04.003 · Cited by 42
Tilleux, S., & Hermans, E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05305.x · Cited by 39
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Dittlau, K. S., & Freude, K. (2024) · Biomolecules · doi:10.3390/biom14030289 · Cited by 39
Müller, M., Jacobi, E., Sakimura, K., Malinow, R., & von Engelhardt, J. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0611-4 · Cited by 40
Mota, S. I., Ferreira, I. L., Valero, J., Ferreiro, E. B., Carvalho, A. L., Oliveira, C. R., & Rego, A. C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.07.023 · Cited by 38
Pham, C., Hérault, K., Oheim, M., Maldera, S., Vialou, V., Cauli, B., & Li, D. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01146-1 · Cited by 36
Han, X., Yang, L., Du, H., Sun, Q., Wang, X., Cong, L., Liu, X., Yin, L., Li, S., & Du, Y. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0268-5 · Cited by 36
Matias, I. C. P., Diniz, L. P., Araújo, A. P. B., Damico, I. V., de Moura, P., Cabral‐Miranda, F., Diniz, F., Parmeggiani, B., Coelho, V. D. M., Leite, R. E. P., et al. (2023) · ASN NEURO · doi:10.1177/17590914231157974 · Cited by 34
Wang, X., Sha, L., Sun, N., Shen, Y., & Xu, Q. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9590-7 · Cited by 36
The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease
Tang, Y., Yan, Y., Mao, J., Ni, J., & Qing, H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101865 · Cited by 34
Báez-Becerra, C. T., Filipello, F., Sandoval-Hernández, A. G., Arboleda, H., & Arboleda, G. (2018) · Neurotoxicity Research · doi:10.1007/s12640-017-9845-3 · Cited by 34
Unravelling the glial response in the pathogenesis of Alzheimer's disease
Alibhai, J. D., Diack, A. B., & Manson, J. C. (2018) · The FASEB Journal · doi:10.1096/fj.201801360r · Cited by 31
Ali, M., Saleem, U., Anwar, F., Imran, M., Nadeem, H., Ahmad, B., Ali, T., Atta-ur-Rehman, & Ismail, T. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03229-w · Cited by 31
Dimpfel, W., & Hoffmann, J. (2011) · BMC Pharmacology · doi:10.1186/1471-2210-11-2 · Cited by 32
Caldérari, S., Ria, M., Gérard, C., Nogueira, T. C., Villate, O., Collins, S. C., Neil, H., Gervasi, N., Hue, C., Suárez-Zamorano, N., et al. (2017) · Genomics · doi:10.1016/j.ygeno.2017.09.001 · Cited by 32
Meeker, K. D., Meabon, J. S., & Cook, D. G. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142304 · Cited by 31
Behnke, J. A., Ye, C., Setty, A., Moberg, K. H., & Zheng, J. Q. (2021) · Scientific Reports · doi:10.1038/s41598-021-89121-7 · Cited by 34
Distribution Patterns of Astrocyte Populations in the Human Cortex
Forrest, S. L., Kim, J. H., Crockford, D. R., Huynh, K., Cheong, R., Knott, S., Kane, M. A., Ittner, L. M., Halliday, G. M., & Kril, J. J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03700-2 · Cited by 34
Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review
Golmohammadi, M., Mahmoudian, M., Hasan, E. K., Alshahrani, S. H., Romero‐Parra, R. M., Malviya, J., Hjazi, A. M., Najm, M. A. A., Almulla, A. F., Zamanian, M. Y., et al. (2023) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12955 · Cited by 32
Griffith, C. M., Xie, M.-X., Qiu, W., Sharp, A. A., Ma, C., Pan, A., Yan, X., & Patrylo, P. R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.08.034 · Cited by 33
Astrocytes: From the Physiology to the Disease
Trujillo‐Estrada, L., Gómez-Arboledas, Á., Forner, S., Martini, A. C., Gutiérrez, A., Baglietto‐Vargas, D., & LaFerla, F. M. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190830110152 · Cited by 30
Kravitz, E., Gaisler-Salomon, I., & Biegon, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081244 · Cited by 30
EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review
Wood, O. W. G., Yeung, J. H. Y., Faull, R. L. M., & Kwakowsky, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.952096 · Cited by 33
Potential of food-derived bioactive peptides in alleviation and prevention of Alzheimer's disease
Zhao, L., Li, D., Qi, X., Guan, K., Chen, H., Wang, R., & Ma, Y. (2022) · Food & Function · doi:10.1039/d2fo02278h · Cited by 29
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Li, L. (2010) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2010.00005 · Cited by 33
Inflammatory Cytokine, IL-1β, Regulates Glial Glutamate Transporter via microRNA-181a in vitro
Zumkehr, J., Rodríguez‐Ortiz, C. J., Medeiros, R., & Kitazawa, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170828 · Cited by 28
Wu, J., Bie, B., Foss, J. F., & Naguib, M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01885-7 · Cited by 28
Compounds with neuroprotective activity from the medicinal plantMachilus thunbergii
Ma, C. J., Kim, Y. C., & Sung, S. H. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360802632971 · Cited by 28
Lan, Y., Zou, S., Chen, J.-J., Zhao, J., & Li, S. (2016) · Neural Plasticity · doi:10.1155/2016/4626593 · Cited by 29
Alterations of some membranetransportproteins in Alzheimer's disease: role of amyloid β-peptide
Rukhsana Sultana, A., & Butterfield, D. A. (2007) · Molecular BioSystems · doi:10.1039/b715278g · Cited by 29
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Scarano, N., Musumeci, F., Casini, B., Brullo, C., D’Ursi, P., Fossa, P., Schenone, S., & Cichero, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146980 · Cited by 32
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Huffels, C. F. M., Middeldorp, J., & Hol, E. M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03699-6 · Cited by 29
Roy, A., Modi, K. K., Khasnavis, S., Ghosh, S., Watson, R. L., & Pahan, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101883 · Cited by 27
Zoltowska, K. M., Maesako, M., Meier, J. C., & Berezovska, O. (2018) · Scientific Reports · doi:10.1038/s41598-018-26888-2 · Cited by 27
Ghatak, S., Nakamura, T., & Lipton, S. A. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1099467 · Cited by 26
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Alam, M. A., & Datta, P. K. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01510 · Cited by 26
Yeung, J. H. Y., Palpagama, T. H., Wood, O. W. G., Turner, C. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.702824 · Cited by 26
Glutamate Metabolism in Mitochondria is Closely Related to Alzheimer’s Disease
Song, J., Yang, X., Zhang, M., Wang, C., & Chen, L. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210595 · Cited by 25
Yatomi, Y., Tanaka, R., Shimura, H., Miyamoto, N., Yamashiro, K., Takanashi, M., Urabe, T., & Hattori, N. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.018 · Cited by 26
Genetics of essential tremor: From phenotype to genes, insights from both human and mouse studies
Schmouth, J.-F., Dion, P. A., & Rouleau, G. A. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.05.001 · Cited by 27
Astroglial contribution to tau-dependent neurodegeneration
Sidoryk‐Wȩgrzynowicz, M., & Strużyńska, L. (2019) · Biochemical Journal · doi:10.1042/bcj20190506 · Cited by 26
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Ugbode, C., Hu, Y., Whalley, B., Peers, C., Rattray, M., & Dallas, M. L. (2017) · Biochemical Journal · doi:10.1042/bcj20160505 · Cited by 25
Foster, J. B., Lashley, R., Zhao, F., Wang, X., Kung, N., Askwith, C. C., Lin, L., Shultis, M. W., Hodgetts, K. J., & Lin, C. G. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0530-z · Cited by 26
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Cortés-Malagón, E. M., Ornelas, A. L., Olvera‐Gómez, I., & Bonilla‐Delgado, J. (2024) · Brain Sciences · doi:10.3390/brainsci14090950 · Cited by 27
Pow, D. V., & Cook, D. G. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9957-0 · Cited by 26
Pharmacological treatment in moderate-to-severe Alzheimer's disease
Hsiung, G. R., & Feldman, H. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.15.2575 · Cited by 24
Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s Disease
Zhang, X., Lao, K., Qiu, Z., Rahman, M. S., Zhang, Y., & Gou, X. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181084 · Cited by 24
Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity
Koller, E. J., & Chakrabarty, P. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00151 · Cited by 23
Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein
Rajão‐Saraiva, J., Dunot, J., Ribera, A., Temido‐Ferreira, M., Coelho, J. E., König, S., Moréno, S., Enguita, F. J., Willem, M., Kins, S., et al. (2023) · Aging Cell · doi:10.1111/acel.13778 · Cited by 25
Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement
Modi, K. K., Rangasamy, S. B., Dasarathi, S., Roy, A., & Pahan, K. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9693-6 · Cited by 22
When Language Breaks Down: Analysing Discourse in Clinical Contexts
Elissa, D., & de Villiers, J. (2010) · Medical Entomology and Zoology · Cited by 22
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 25
Kilian, J., Hsu, H.-W., Mata, K., Wolf, F. W., & Kitazawa, M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.011 · Cited by 21
NMDARs in Alzheimer’s Disease: Between Synaptic and Extrasynaptic Membranes
Escamilla, S., Sáez‐Valero, J., & Cuchillo‐Ibáñez, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810220 · Cited by 22
Huffels, C. F. M., Osborn, L. M., Hulshof, L. A., Kooijman, L., Henning, L., Steinhäuser, C., & Hol, E. M. (2022) · Glia · doi:10.1002/glia.24137 · Cited by 20
Monteiro‐Fernandes, D., Silva, J. M., Soares‐Cunha, C., Dalla, C., Kokras, N., Arnaud, F., Billiras, R., Zhuravleva, V., Waites, C. L., Bretin, S., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0794-5 · Cited by 20
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Metadata
- Authors
- Jacob, C. P., Koutsilieri, E., Bartl, J., Neuen-Jacob, E., Arzberger, T., Zander, N., Ravid, R., Roggendorf, W., Riederer, P., & Grünblatt, E.
- Affiliations
- University of Würzburg (DE)
- Heinrich Heine University Düsseldorf (DE)
- Netherlands Brain Bank (NL)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2007-03-01
- Volume
- 11
- Issue
- 1
- Pages
- 97-116
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W118386170
- Cited by
- 317
- References
- 40
- Citations by year
- 2026: 11 · 2025: 31 · 2024: 14 · 2023: 19 · 2022: 29 · 2021: 23 · 2020: 26 · 2019: 18 · 2018: 19 · 2017: 14 · 2016: 14 · 2015: 17 · 2014: 11 · 2013: 11 · 2012: 8
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Reference Values, Receptors, Glutamate, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Glutamate Plasma Membrane Transport Proteins, Plaque, Amyloid
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