The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Oxidative Stress in Diabetes and Alzheimer's Disease
Open accessAbstract
Oxidative stress plays a major role in diabetes as well as in Alzheimer's disease and other related neurological diseases. Intracellular oxidative stress arises due to the imbalance in the production of reactive oxygen/reactive nitrogen species and cellular antioxidant defense mechanisms. In turn, the excess reactive oxygen/reactive nitrogen species mediate the damage of proteins and nucleic acids, which have been shown to have direct and deleterious consequences in diabetes and Alzheimer's disease. Oxidative stress also contributes to the production of advanced glycation end products through glycoxidation and lipid peroxidation. The advanced glycation end products and lipid peroxidation products are ubiquitous to diabetes and Alzheimer's disease and serve as markers of disease progression in both disorders. Antioxidants and advanced glycation end products inhibitors, either induced endogenously or exogenously introduced, may counteract with the deleterious effects of the reactive oxygen/reactive nitrogen species and thereby, in prevention or treatment paradigms, attenuate or substantially delay the onset of these devastating pathologies.
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Cites
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Oxidative Damage Is the Earliest Event in Alzheimer Disease
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Self-citationMitochondrial abnormalities in Alzheimer's disease
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Self-citationIron accumulation in Alzheimer disease is a source of redox-generated free radicals
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Self-citationUnderstanding RAGE, the receptor for advanced glycation end products
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Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
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Protein Glycation, Diabetes, and Aging
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Cited by
Current and future treatments for Alzheimer's disease
Yiannopoulou, K. G., & Papageorgiou, S. G. (2013) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285612461679 · Cited by 677
How does diabetes accelerate Alzheimer disease pathology?
Sims-Robinson, C., Kim, B., Rosko, A., & Feldman, E. L. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.130 · Cited by 492
Redox Regulation in Cancer: A Double‐edged Sword with Therapeutic Potential
Acharya, A., Das, I., Chandhok, D., & Saha, T. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.1.10095 · Cited by 486
Exercise-induced oxidative stress in humans: cause and consequences
Powers, S. K., Nelson, W. B., & Hudson, M. B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.009 · Cited by 441
Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.010 · Cited by 402
Metadata
- Authors
- Reddy, V. P., Zhu, X., Perry, G., & Smith, M. A.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2009-04-17
- Volume
- 16
- Issue
- 4
- Pages
- 763-774
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1597763516
- Cited by
- 280
- References
- 105
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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