The Pathobiology of Diabetic Complications

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023 · see citing works

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works

Oxidative Stress and Diabetic Vascular Complications

Giugliano, D., Ceriello, A., & Paolisso, G. (1996) · Diabetes Care · doi:10.2337/diacare.19.3.257 · Cited by 1,938 · see citing works

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727 · see citing works

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,542 · see citing works

Protein kinase C activation and the development of diabetic complications.

Koya, D., & King, G. L. (1998) · Diabetes · doi:10.2337/diabetes.47.6.859 · Cited by 1,335 · see citing works

Diseases of the mitochondrial DNA

Wallace, D. C. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005523 · Cited by 1,319 · see citing works

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

Du, X.-L., Edelstein, D., Rossetti, L., Fantus, I. G., Goldberg, H. J., Ziyadeh, F. N., Wu, J., & Brownlee, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.12222 · Cited by 1,152 · see citing works

Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor

Ishii, H., Jirousek, M. R., Koya, D., Takagi, C., Xia, P., Clermont, A. C., Bursell, S., Kern, T. S., Ballas, L. M., Heath, W. F., et al. (1996) · Science · doi:10.1126/science.272.5262.728 · Cited by 1,103 · see citing works

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907 · see citing works

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118175 · Cited by 896 · see citing works

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

Du, X., Matsumura, T., Edelstein, D., Rossetti, L., Zsengellér, Z. K., Szabó, C., & Brownlee, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18127 · Cited by 832 · see citing works

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

Hammes, H.-P., Du, X., Edelstein, D., Taguchi, T., Matsumura, T., Ju, Q., Lin, J., Bierhaus, A., Nawroth, P., Hannak, D., et al. (2003) · Nature Medicine · doi:10.1038/nm834 · Cited by 785 · see citing works

Homeostasis Model Assessment of Insulin Resistance in Relation to the Incidence of Cardiovascular Disease

Hanley, A. J., Williams, K., D, M. P. S. M., & Haffner, S. M. (2002) · Diabetes Care · doi:10.2337/diacare.25.7.1177 · Cited by 637 · see citing works

Regulation of Endothelial Constitutive Nitric Oxide Synthase Gene Expression in Endothelial Cells and In Vivo

Kuboki, K., Jiang, Z. Y., Takahara, N., Ha, S. W., Igarashi, M., Yamauchi, T., Feener, E. P., Herbert, T. P., Rhodes, C. J., & King, G. L. (2000) · Circulation · doi:10.1161/01.cir.101.6.676 · Cited by 636 · see citing works

Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

Kuhlencordt, P. J., Gyurko, R., Han, F., Scherrer‐Crosbie, M., Aretz, T. H., Hajjar, R. J., Picard, M. H., & Huang, P. L. (2001) · Circulation · doi:10.1161/hc2901.091399 · Cited by 631 · see citing works

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

Vlassara, H., Brownlee, M., Manogue, K. R., Dinarello, C. A., & Pasagian, A. (1988) · Science · doi:10.1126/science.3259727 · Cited by 597 · see citing works

The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex.

Trumpower, B. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38410-8 · Cited by 596 · see citing works

Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic Complications

McLellan, A. C., Thornalley, P. J., Benn, J. J., & Sönksen, P. H. (1994) · Clinical Science · doi:10.1042/cs0870021 · Cited by 557 · see citing works

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

Koya, D., Jirousek, M. R., Lin, Y. W., Ishii, H., Kuboki, K., & King, G. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119503 · Cited by 535 · see citing works

Contributions of polyol pathway to oxidative stress in diabetic cataract

Lee, A. Y. W., & Chung, S. S. M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.23 · Cited by 533 · see citing works

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.

Hammes, H., Martin, S., Federlin, K., Geisen, K., & Brownlee, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11555 · Cited by 523 · see citing works

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

Shinohara, M., Thornalley, P. J., Giardino, I., Beisswenger, P. J., Thorpe, S. R., Onorato, J., & Brownlee, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119885 · Cited by 513 · see citing works

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

Salvemini, D., Wang, Z., Zweier, J. L., Samouilov, A., Macarthur, H., Misko, T. P., Currie, M. G., Cuzzocrea, S., Sikorski, J. A., & Riley, D. P. (1999) · Science · doi:10.1126/science.286.5438.304 · Cited by 502 · see citing works

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

Xia, P., Inoguchi, T., Kern, T. S., Engerman, R. L., Oates, P. J., & King, G. L. (1994) · Diabetes · doi:10.2337/diab.43.9.1122 · Cited by 476 · see citing works

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

Koya, D., Haneda, M., Nakagawa, H., Isshiki, K., Sato, H., Maeda, S., Sugimoto, T., Yasuda, H., Kashiwagi, A., Ways, D. K., et al. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.3.439 · Cited by 426 · see citing works

Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex

Vlassara, H., Li, Y. M., Imani, F., Wojciechowicz, D., Yang, Z., Liu, F.-T., & Cerami, A. (1995) · Molecular Medicine · doi:10.1007/bf03401604 · Cited by 421 · see citing works

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

Kolm-Litty, V., Sauer, U., Nerlich, A., Lehmann, R., & Schleicher, E. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119875 · Cited by 413 · see citing works

Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes

Gabbay, K. H., MEROLA, L. O., & Field, R. A. (1966) · Science · doi:10.1126/science.151.3707.209 · Cited by 400 · see citing works

Diabetes and the Accompanying Hyperglycemia Impairs Cardiomyocyte Calcium Cycling through Increased Nuclear O-GlcNAcylation

Clark, R. J., McDonough, P. M., Swanson, E., Trost, S. U., Suzuki, M., Fukuda, M., & DILLMANN, W. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303810200 · Cited by 382 · see citing works

Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice

Kobayashi, T., Tahara, Y., Matsumoto, M., Iguchi, M., Sano, H., Murayama, T., Arai, H., Oida, H., Yurugi-Kobayashi, T., Yamashita, J. K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421446 · Cited by 374 · see citing works

Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells

Federici, M., Menghini, R., Mauriello, A., Hribal, M. L., Ferrelli, F., Lauro, D., Sbraccia, P., Spagnoli, L. G., Sesti, G., & Lauro, R. (2002) · Circulation · doi:10.1161/01.cir.0000023043.02648.51 · Cited by 372 · see citing works

Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

Giardino, I., Edelstein, D., & Brownlee, M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117296 · Cited by 364 · see citing works

Differential Regulation of Glucose Transport and Transporters by Glucose in Vascular Endothelial and Smooth Muscle Cells

Kaiser, N., Sasson, S., Feener, E. P., Boukobza-Vardi, N., Higashi, S., Moller, D. E., Davidheiser, S., Przybylski, R. J., & King, G. L. (1993) · Diabetes · doi:10.2337/diab.42.1.80 · Cited by 358 · see citing works

Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.

Doi, T., Vlassara, H., Kirstein, M., Yamada, Y., Striker, G. E., & Striker, L. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2873 · Cited by 349 · see citing works

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

Li, Y. M., Mitsuhashi, T., Wojciechowicz, D. C., Shimizu, N., Li, J., Stitt, A. W., He, C., Banerjee, D., & Vlassara, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.11047 · Cited by 340 · see citing works

Glyceraldehyde-3-phosphate dehydrogenase: Nuclear translocation participates in neuronal and nonneuronal cell death

Sawa, A., Khan, A. A., Hester, L. D., & Snyder, S. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11669 · Cited by 316 · see citing works

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

DeRubertis, F. R., & Craven, P. A. (1994) · Diabetes · doi:10.2337/diabetes.43.1.1 · Cited by 276 · see citing works

Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype.

Heilig, C. W., Concepcion, L. A., Riser, B. L., Freytag, S. O., Zhu, M., & Cortés, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118226 · Cited by 270 · see citing works

Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins.

Kirstein, M., Aston, C., Hintz, R. L., & Vlassara, H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115879 · Cited by 264 · see citing works

Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy.

Skolnik, E. Y., Yang, Z., Makita, Z., Radoff, S., Kirstein, M., & Vlassara, H. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.4.931 · Cited by 242 · see citing works

Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells

Smedsrød, B. H., Melkko, J., Araki, N., Sano, H., & Horiuchi, S. (1997) · Biochemical Journal · doi:10.1042/bj3220567 · Cited by 225 · see citing works

O‐GlcNAc turns twenty: functional implications for post‐translational modification of nuclear and cytosolic proteins with a sugar

Wells, L., & Hart, G. W. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00641-0 · Cited by 205 · see citing works

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

Studer, R. K., Craven, P. A., & DeRubertis, F. R. (1993) · Diabetes · doi:10.2337/diab.42.1.118 · Cited by 180 · see citing works

Glucose Metabolism to Glucosamine Is Necessary for Glucose Stimulation of Transforming Growth Factor-α Gene Transcription

Sayeski, P. P., & Kudlow, J. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15237 · Cited by 171 · see citing works

Laminin Alterations After In Vitro Nonenzymatic Glycosylation

CHARONIS, A. S., Reger, L. A., Dege, J. E., Kouzi‐Koliakos, K., Furcht, L. T., Wohlhueter, R. M., & Tsilibary, E. C. (1990) · Diabetes · doi:10.2337/diab.39.7.807 · Cited by 164 · see citing works

Attenuation of Renal Injury in db/db Mice Overexpressing Superoxide Dismutase

DeRubertis, F. R., Craven, P. A., Melhem, M. F., & Salah, E. (2004) · Diabetes · doi:10.2337/diabetes.53.3.762 · Cited by 127 · see citing works

Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs

Engerman, R. L., Kern, T. S., & Larson, M. E. (1994) · Diabetologia · doi:10.1007/s001250050084 · Cited by 111 · see citing works

The kinetics of translocation and cellular quantity of protein kinase C in human leukocytes are modified during spaceflight

Hatton, J. P., Gaubert, F., Lewis, M. L., et al. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9001.s23 · Cited by 79 · see citing works

Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells

Kaiser, Ν., Sasson, S., Feener, E. P., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.1.80 · Cited by 73 · see citing works

Reversible nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase upon serum depletion

Schmitz, H.-D. (2001) · European Journal of Cell Biology · doi:10.1078/0171-9335-00174 · Cited by 66 · see citing works

Synthesis and secretion of tumour necrosis factor-α by human monocytic THP-1 cells and chemotaxis induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts

Abordo, E. A., & Thornalley, P. J. (1997) · Immunology Letters · doi:10.1016/s0165-2478(97)00080-1 · Cited by 57 · see citing works

Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium

Studer, R. K., Craven, P. A., & DeRubertis, F. R. (1993) · Diabetes · doi:10.2337/diabetes.42.1.118 · Cited by 57 · see citing works

Role of Protein Kinase C in Glucose- and Angiotensin II-Induced Plasminogen Activator Inhibitor Expression1

Feener, E. P., Xia, P., Inoguchi, T., Shiba, T., Kunisaki, M., & King, G. L. (2015) · Contributions to nephrology · doi:10.1159/000425092 · Cited by 52 · see citing works

Matrix protein glycation impairs agonist‐induced intracellular Ca2+ signaling in endothelial cells

Bishara, N. B., Dunlop, M., Murphy, T. V., Darby, I. A., Rajanayagam, M. A. S., & Hill, M. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10153 · Cited by 33 · see citing works

Oxidative stress and diabetic complications

Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works

Type 2 diabetes mellitus

DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611 · see citing works

Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes

Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.-P., & Colette, C. (2006) · JAMA · doi:10.1001/jama.295.14.1681 · Cited by 2,444 · see citing works

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30051-2 · Cited by 2,335 · see citing works

Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms

Petrie, J. R., Guzik, T. J., & Touyz, R. M. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.12.005 · Cited by 1,787 · see citing works

Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: Molecular and Pathophysiological Mechanisms

Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652 · see citing works

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

El-Osta, A., Brasacchio, D., Yao, D., Pocai, A., Jones, P. L., Roeder, R. G., Cooper, M. E., & Brownlee, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081188 · Cited by 1,115 · see citing works

Role of Mitochondrial Dysfunction in Insulin Resistance

Kim, J.-A., Wei, Y., & Sowers, J. R. (2008) · Circulation Research · doi:10.1161/circresaha.107.165472 · Cited by 1,103 · see citing works

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063 · see citing works

Oxidative stress in obesity: A critical component in human diseases

Marseglia, L., Manti, S., D’Angelo, G., Nicotera, A., Parisi, E., Di Rosa, G., Gitto, E., & Arrigo, T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010378 · Cited by 933 · see citing works

Cross talk between mitochondria and NADPH oxidases

Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783 · see citing works

Diastolic Stiffness of the Failing Diabetic Heart: Importance of Fibrosis, Advanced Glycation End Products, and Myocyte Resting Tension

van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.728550 · Cited by 723 · see citing works

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

Newsholme, P., Haber, E. P., Hirabara, S. M., Rebelato, E. L. O., Procopio, J., Morgan, D., Oliveira‐Emilio, H. C., Carpinelli, A. R., & Curi, R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135871 · Cited by 684 · see citing works

Diabetes and Kidney Disease: Role of Oxidative Stress

Jha, J. C., Banal, C., Chow, B. S. M., Cooper, M. E., & Jandeleit-Dahm, K. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6664 · Cited by 660 · see citing works

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

Chaudhuri, J., Bains, Y., Guha, S., Kahn, A., Hall, D., Bose, N., Gugliucci, A., & Kapahi, P. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.014 · Cited by 669 · see citing works

Reactive oxygen species (ROS) in macrophage activation and function in diabetes

Rendra, E., Riabov, V., Mossel, D. M., Sevastyanova, T., Harmsen, M. C., & Kzhyshkowska, J. (2019) · Immunobiology · doi:10.1016/j.imbio.2018.11.010 · Cited by 636 · see citing works

Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents

Di Pino, A., & DeFronzo, R. A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00141 · Cited by 535 · see citing works

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

Boushel, R., Gnaiger, E., Schjerling, P., Skovbro, M., Kraunsøe, R., & Dela, F. (2007) · Diabetologia · doi:10.1007/s00125-007-0594-3 · Cited by 519 · see citing works

Glycemic Variability: A Hemoglobin A_1c–Independent Risk Factor for Diabetic Complications

Brownlee, M., & Hirsch, I. B. (2006) · JAMA · doi:10.1001/jama.295.14.1707 · Cited by 482 · see citing works

Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects

Perrone, A., Giovino, A., Benny, J., & Martinelli, F. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3818196 · Cited by 459 · see citing works

The hallmarks of mitochondrial dysfunction in chronic kidney disease

Galvan, D. L., Green, N. H., & Danesh, F. R. (2017) · Kidney International · doi:10.1016/j.kint.2017.05.034 · Cited by 447 · see citing works

Metabolic and nutritional support of critically ill patients: consensus and controversies

Preiser, J.-C., van Zanten, A. R., Berger, M. M., Biolo, G., Casaer, M. P., Doig, G. S., Griffiths, R. D., Heyland, D. K., Hiesmayr, M., Iapichino, G., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0737-8 · Cited by 416 · see citing works

Glucose Variability; Does It Matter?

Siegelaar, S. E., Holleman, F., Hoekstra, J. B. L., & DeVries, J. H. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0021 · Cited by 409 · see citing works

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.010 · Cited by 402 · see citing works

Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis

Lu, F.-P., Lin, K.-P., & Kuo, H.-K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004144 · Cited by 398 · see citing works

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

Tahrani, A. A., Barnett, A. H., & Bailey, C. J. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.86 · Cited by 398 · see citing works

Endothelial Mitochondria: Contributing to Vascular Function and Disease

Davidson, S. M., & Duchen, M. R. (2007) · Circulation Research · doi:10.1161/01.res.0000261970.18328.1d · Cited by 381 · see citing works

Glycemic control and complications in type 2 diabetes mellitus

Stolar, M. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.12.004 · Cited by 356 · see citing works

Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease

Dikalov, S. I., & Nazarewicz, R. R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4604 · Cited by 356 · see citing works

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, G., & Karin, M. (2010) · The FASEB Journal · doi:10.1096/fj.09-151340 · Cited by 347 · see citing works

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

Mitchell, S. J., Bernier, M., Aon, M. A., Cortassa, S., Kim, E. Y., Fang, E. F., Palacios, H. H., Ali, A., Navas-Enamorado, I., Di Francesco, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.001 · Cited by 338 · see citing works

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential

Fujita, H., Morii, T., Fujishima, H., Sato, T., Shimizu, T., Hosoba, M., Tsukiyama, K., Narita, T., Takahashi, T., Drucker, D. J., et al. (2014) · Kidney International · doi:10.1038/ki.2013.427 · Cited by 336 · see citing works

Oxidative Damage in the Retinal Mitochondria of Diabetic Mice: Possible Protection by Superoxide Dismutase

Kanwar, M., Chan, P.-S., Kern, T. S., & Kowluru, R. A. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-1280 · Cited by 333 · see citing works

The Pathophysiology of Cardiovascular Disease and Diabetes: Beyond Blood Pressure and Lipids

Dokken, B. B. (2008) · Diabetes Spectrum · doi:10.2337/diaspect.21.3.160 · Cited by 299 · see citing works

Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift

Nolan, C. J., & Prentki, M. (2019) · Diabetes and Vascular Disease Research · doi:10.1177/1479164119827611 · Cited by 292 · see citing works

The role of glucose transporters in brain disease: Diabetes and Alzheimer’s disease

Shah, K., DeSilva, S., & Abbruscato, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012629 · Cited by 288 · see citing works

Oxidative stress and metabolic pathologies: from an adipocentric point of view

Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291 · see citing works

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

Zheng, Z., Chen, H., Li, J., Li, T., Zheng, B., Zheng, Y., Jin, H., He, Y., Gu, Q., & Xu, X. (2012) · Diabetes · doi:10.2337/db11-0416 · Cited by 282 · see citing works

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

Yang, D., Livingston, M. J., Liu, Z., Dong, G., Zhang, M., Chen, J.-K., & Dong, Z. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2639-1 · Cited by 252 · see citing works

Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions

Halter, J. B., Musi, N., McFarland Horne, F., Crandall, J. P., Goldberg, A., Harkless, L., Hazzard, W. R., Huang, E. S., Kirkman, M. S., Plutzky, J., et al. (2014) · Diabetes · doi:10.2337/db14-0020 · Cited by 255 · see citing works

Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

Stuart, M. J., & Baune, B. T. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.001 · Cited by 257 · see citing works

Kidney disease and related findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study

de Boer, I. H., & for the DCCT/EDIC Research Group (2014) · Diabetes Care · doi:10.2337/dc13-2113 · Cited by 254 · see citing works

Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers

Mechanick, J. I., Farkouh, M. E., Newman, J. D., & Garvey, W. T. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.044 · Cited by 243 · see citing works

Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress

Kowluru, R. A., Kowluru, V., Xiong, Y., & Ho, Y.-S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.012 · Cited by 233 · see citing works

Almonds Decrease Postprandial Glycemia, Insulinemia, and Oxidative Damage in Healthy Individuals

Jenkins, D. J. A., Kendall, C. W. C., Josse, A. R., Salvatore, S., Brighenti, F., Augustin, L. S. A., Ellis, P. R., Vidgen, E., & Rao, A. V. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.12.2987 · Cited by 226 · see citing works

Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases

Gugliucci, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013912 · Cited by 225 · see citing works

The Hemoglobin A1c Level as a Progressive Risk Factor for Cardiovascular Death, Hospitalization for Heart Failure, or Death in Patients With Chronic Heart Failure: An Analysis of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program

Gerstein, H. C. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1699 · Cited by 217 · see citing works

Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women

Juutilainen, A., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (2007) · Diabetes Care · doi:10.2337/dc06-1747 · Cited by 209 · see citing works

Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism

König, M., Bulik, S., & Holzhütter, H.-G. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002577 · Cited by 202 · see citing works

‘Exercise snacks’ before meals: a novel strategy to improve glycaemic control in individuals with insulin resistance

Francois, M. E., Baldi, J. C., Manning, P. J., Lucas, S. J. E., Hawley, J. A., Williams, M. J. A., & Cotter, J. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3244-6 · Cited by 204 · see citing works

The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194 · see citing works

Diabetes mellitus and stroke: A clinical update

Tun, N. N., Arunagirinathan, G., Munshi, S. K., & Pappachan, J. M. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i6.235 · Cited by 177 · see citing works

Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity

Gaens, K. H., Stehouwer, C. D., & Schalkwijk, C. G. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835aea13 · Cited by 166 · see citing works

Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction

Szabo, C. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00086.x · Cited by 165 · see citing works

The relationship between glycemic variability and diabetic peripheral neuropathy in type 2 diabetes with well-controlled HbA1c

Xu, F., Zhao, L.-H., Su, J.-B., Chen, T., Wang, X.-Q., Chen, J.-F., Wu, G., Jin, Y., & Wang, X.-H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-139 · Cited by 159 · see citing works

Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy

Vincent, A. M., Edwards, J. L., McLean, L. L., Hong, Y., Cerri, F., Lopez, I., Quattrini, A., & Feldman, E. L. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0697-7 · Cited by 152 · see citing works

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance

Hoeks, J., van Herpen, N. A., Mensink, M., Moonen-Kornips, E., van Beurden, D., Hesselink, M. K. C., & Schrauwen, P. (2010) · Diabetes · doi:10.2337/db10-0519 · Cited by 156 · see citing works

Deep transfer learning and data augmentation improve glucose levels prediction in type 2 diabetes patients

Deng, Y., Lu, L., Aponte, L., Angelidi, A. M., Novak, V., Karniadakis, G. E., & Mantzoros, C. S. (2021) · npj Digital Medicine · doi:10.1038/s41746-021-00480-x · Cited by 152 · see citing works

The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

Pagel-Langenickel, I., Bao, J., Pang, L., & Sack, M. N. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0003 · Cited by 154 · see citing works

Acute hyperglycemia and oxidative stress: Direct cause and effect?

Choi, S.-W., Benzie, I. F. F., Ma, S.-W., Strain, J. J., & Hannigan, B. M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.005 · Cited by 149 · see citing works

Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant?

Nuttall, F. Q., Ngo, A., & Gannon, M. C. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.863 · Cited by 146 · see citing works

Advanced Glycation End Products, Oxidation Products, and Incident Cardiovascular Events in Patients With Type 2 Diabetes

Koska, J., Saremi, A., Howell, S., Bahn, G., De Courten, B., Ginsberg, H., Beisswenger, P. J., Reaven, P. D., & for the VADT Investigators (2018) · Diabetes Care · doi:10.2337/dc17-1740 · Cited by 134 · see citing works

Endothelial Function and Dysfunction: Impact of Metformin

Nafisa, A., Gray, S. G., Cao, Y., Wang, T., Xu, S., Wattoo, F. H., Barras, M., Cohen, N., Kamato, D., & Little, P. J. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.007 · Cited by 128 · see citing works

Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients

Krisp, C., Jacobsen, F., McKay, M. J., Molloy, M. P., Steinstraesser, L., & Wolters, D. A. (2013) · PROTEOMICS · doi:10.1002/pmic.201200502 · Cited by 124 · see citing works

α-Lipoic Acid Prevents the Increase in Atherosclerosis Induced by Diabetes in Apolipoprotein E–Deficient Mice Fed High-Fat/Low-Cholesterol Diet

Yi, X., & Maeda, N. (2006) · Diabetes · doi:10.2337/db06-0251 · Cited by 117 · see citing works

Comparative effects of microvascular and macrovascular disease on the risk of major outcomes in patients with type 2 diabetes

Mohammedi, K., Woodward, M., Marre, M., Colagiuri, S., Cooper, M., Harrap, S., Mancia, G., Poulter, N., Williams, B., Zoungas, S., et al. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0574-y · Cited by 111 · see citing works

<i>Succination of Proteins by Fumarate</i>: <i>Mechanism of Inactivation of Glyceraldehyde‐3‐Phosphate Dehydrogenase in Diabetes</i>

Blatnik, M., Thorpe, S. R., & Baynes, J. W. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1433.047 · Cited by 109 · see citing works

Myocardial infarction and heart failure in the <i>db/db</i> diabetic mouse

Greer, J. J. M., Ware, D. P., & Lefer, D. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00583.2005 · Cited by 108 · see citing works

Vascular complications in diabetes: Old messages, new thoughts

Forbes, J. M., & Fotheringham, A. K. (2017) · Diabetologia · doi:10.1007/s00125-017-4360-x · Cited by 106 · see citing works

A Synopsis of the Associations of Oxidative Stress, ROS, and Antioxidants with Diabetes Mellitus

Black, H. S. (2022) · Antioxidants · doi:10.3390/antiox11102003 · Cited by 103 · see citing works

Resveratrol Protects Vascular Endothelial Cells from High Glucose–Induced Apoptosis through Inhibition of <scp>NADPH</scp> Oxidase Activation–Driven Oxidative Stress

Chen, F., Qian, L., Deng, B., Liu, Z., Zhao, Y., & Le, Y. (2013) · CNS Neuroscience &amp; Therapeutics · doi:10.1111/cns.12131 · Cited by 101 · see citing works

PPARα: an emerging therapeutic target in diabetic microvascular damage

Hiukka, A., Maranghi, M., Matikainen, N., & Taskinen, M.-R. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.89 · Cited by 103 · see citing works

Dietary Patterns and Cardiovascular Disease Risk in People with Type 2 Diabetes

Archundia Herrera, M. C., Subhan, F. B., & Chan, C. B. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0284-5 · Cited by 98 · see citing works

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Lotti, F., Corona, G., Degli Innocenti, S., Filimberti, E., Scognamiglio, V., Vignozzi, L., Forti, G., & Maggi, M. (2013) · Andrology · doi:10.1111/j.2047-2927.2012.00031.x · Cited by 96 · see citing works

Advanced Glycation End Products (AGEs), but not High Glucose, Inhibit the Osteoblastic Differentiation of Mouse Stromal ST2 Cells Through the Suppression of Osterix Expression, and Inhibit Cell Growth and Increasing Cell Apoptosis

Okazaki, K., Yamaguchi, T., Tanaka, K.-I., Notsu, M., Ogawa, N., Yano, S., & Sugimoto, T. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9641-2 · Cited by 98 · see citing works

Myeloid cell dysfunction and the pathogenesis of the diabetic chronic wound

Wicks, K., Torbica, T., & Mace, K. A. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.006 · Cited by 93 · see citing works

Empagliflozin Ameliorates Type 2 Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female db/db Mouse

Hayden, M., Grant, D., Aroor, A., & DeMarco, V. (2019) · Brain Sciences · doi:10.3390/brainsci9030057 · Cited by 93 · see citing works

Integrating glycaemic variability in the glycaemic disorders of type 2 diabetes: A move towards a unified glucose tetrad concept

Monnier, L., Colette, C., & Owens, D. R. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.962 · Cited by 89 · see citing works

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: Metabolic basis for dementia

Xu, J., Begley, P., Church, S. J., Patassini, S., McHarg, S., Kureishy, N., Hollywood, K. A., Waldvogel, H. J., Liu, H., Zhang, S., et al. (2016) · Scientific Reports · doi:10.1038/srep27524 · Cited by 85 · see citing works

Antioxidant Phytochemicals as Potential Therapy for Diabetic Complications

Akpoveso, O.-O. P., Ubah, E. E., & Obasanmi, G. (2023) · Antioxidants · doi:10.3390/antiox12010123 · Cited by 90 · see citing works

Distribution of Phenolic Contents, Antidiabetic Potentials, Antihypertensive Properties, and Antioxidative Effects of Soursop (<i>Annona muricata</i>L.) Fruit Parts<i>In Vitro</i>

Adefegha, S. A., Oyeleye, S. I., & Oboh, G. (2015) · Biochemistry Research International · doi:10.1155/2015/347673 · Cited by 86 · see citing works

Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance

Apostolopoulou, M., Lambadiari, V., Roden, M., & Dimitriadis, G. D. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnae032 · Cited by 90 · see citing works

Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects.

Meugnier, E., Faraj, M., Rome, S., Beauregard, G., Michaut, A., Pelloux, V., Chiasson, J.-L., Laville, M., Clement, K., Vidal, H., et al. (2007) · Diabetes · doi:10.2337/db06-1242 · Cited by 76 · see citing works

Glycated hemoglobin and outcomes in patients with advanced diabetic chronic kidney disease

Kuo, I.-C., Lin, H. Y.-H., Niu, S.-W., Hwang, D.-Y., Lee, J.-J., Tsai, J.-C., Hung, C.-C., Hwang, S.-J., & Chen, H.-C. (2016) · Scientific Reports · doi:10.1038/srep20028 · Cited by 70 · see citing works

Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes.

Rabøl, R., Højberg, P. M. V., Almdal, T., Boushel, R., Haugaard, S. B., Madsbad, S., & Dela, F. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2008-1475 · Cited by 66 · see citing works

Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation

Behnammanesh, G., Durante, Z. E., Peyton, K. J., Martinez-Lemus, L. A., Brown, S. M., Bender, S. B., & Durante, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00362 · Cited by 61 · see citing works

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation

Menini, S., Iacobini, C., Ricci, C., Oddi, G., Pesce, C., Pugliese, F., Block, K., Abboud, H. E., Giorgio, M., Migliaccio, E., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0728-7 · Cited by 64 · see citing works

The metabolic syndrome and endothelial dysfunction: Common highway to type 2 diabetes and CVD?

Diamant, M., & Tushuizen, M. E. (2006) · Current Diabetes Reports · doi:10.1007/s11892-006-0061-4 · Cited by 64 · see citing works

Acute Effects of Dietary Glycemic Index on Antioxidant Capacity in a Nutrient‐controlled Feeding Study

Botero, D., Ebbeling, C. B., Blumberg, J. B., Ribaya‐Mercado, J. D., Creager, M. A., Swain, J. F., Feldman, H. A., & Ludwig, D. S. (2009) · Obesity · doi:10.1038/oby.2009.203 · Cited by 60 · see citing works

Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS)

Perreault, L., Pan, Q., Aroda, V. R., Barrett-Connor, E., Dabelea, D., Dagogo-Jack, S., Hamman, R. F., Kahn, S. E., Mather, K. J., Knowler, W. C., et al. (2017) · Diabetic Medicine · doi:10.1111/dme.13453 · Cited by 55 · see citing works

Exenatide once weekly for the treatment of type 2 diabetes

Malone, J., Trautmann, M., Wilhelm, K., Taylor, K., & Kendall, D. M. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780902766802 · Cited by 55 · see citing works

Etiology of type 2 diabetes and Alzheimer’s disease: Exploring the mitochondria

Silzer, T. K., & Phillips, N. R. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.04.004 · Cited by 53 · see citing works

Exenatide improves ovarian and endometrial injury and preserves ovarian reserve in streptozocin induced diabetic rats

Artunc-Ulkumen, B., Pala, H. G., Pala, E. E., Yavasoglu, A., Yigitturk, G., & Erbas, O. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2014.975686 · Cited by 45 · see citing works

Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases

Suzumura, A., Terao, R., & Kaneko, H. (2020) · Antioxidants · doi:10.3390/antiox9100920 · Cited by 44 · see citing works

Significance of Glycemic Variability in Diabetes Mellitus

Kusunoki, Y., Konishi, K., Tsunoda, T., & Koyama, H. (2022) · Internal Medicine · doi:10.2169/internalmedicine.8424-21 · Cited by 40 · see citing works

Accelerated Aging during Chronic Oxidative Stress: A Role for PARP-1

Boesten, D. M. P. H. J., de Vos-Houben, J. M. J., Timmermans, L., den Hartog, G. J. M., Bast, A., & Hageman, G. J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/680414 · Cited by 37 · see citing works

How tightly controlled do fluctuations in blood glucose levels need to be to reduce the risk of developing complications in people with type 1 diabetes?

Livingstone, R., Boyle, J. G., & Petrie, J. R. (2020) · Diabetic Medicine · doi:10.1111/dme.13911 · Cited by 34 · see citing works

Double-Edged Action of SOD Mimetic in Diabetic Nephropathy

Asaba, K., Tojo, A., Onozato, M. L., Goto, A., & Fujita, T. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31802b6530 · Cited by 35 · see citing works

Tirzepatide alleviates oxidative stress and inflammation in diabetic nephropathy via IL-17 signaling pathway

Yang, Y., Wang, Y., Zhou, Y., Deng, J., & Wu, L. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05066-1 · Cited by 35 · see citing works

Succinate is the controller of O 2 − /H2O2 release at mitochondrial complex I : negative modulation by malate, positive by cyanide

Zoccarato, F., Cavallini, L., & Alexandre, A. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9238-2 · Cited by 31 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK

Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

Interleucinas na encefalopatia hipóxico-isquêmica

Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works